Fluorine in PDB 5o90: Crystal Structure of A P38ALPHA T185G Mutant in Complex with TAB1 Peptide.

All present enzymatic activity of Crystal Structure of A P38ALPHA T185G Mutant in Complex with TAB1 Peptide.:
2.7.11.24;

The structure of Crystal Structure of A P38ALPHA T185G Mutant in Complex with TAB1 Peptide., PDB code: 5o90 was solved by C.E.Nichols, G.F.De Nicola, D.Thapa, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	58.96 / 2.49
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	45.920, 73.580, 58.970, 90.00, 91.09, 90.00
R / Rfree (%)	24.9 / 27.5

The binding sites of Fluorine atom in the Crystal Structure of A P38ALPHA T185G Mutant in Complex with TAB1 Peptide. (pdb code 5o90). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Crystal Structure of A P38ALPHA T185G Mutant in Complex with TAB1 Peptide., PDB code: 5o90:

Fluorine binding site 1 out of 1 in the Crystal Structure of A P38ALPHA T185G Mutant in Complex with TAB1 Peptide.


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Crystal Structure of A P38ALPHA T185G Mutant in Complex with TAB1 Peptide. within 5.0Å range: probe atom residue distance (Å) B Occ A:F401 b:58.1 occ:1.00 FB7 A:SB4401 0.0 58.1 1.0 CB3 A:SB4401 1.3 60.7 1.0 CB2 A:SB4401 2.4 62.3 1.0 CB4 A:SB4401 2.4 68.6 1.0 N A:VAL105 3.3 54.3 1.0 C A:LEU104 3.4 57.1 1.0 C A:VAL105 3.4 57.2 1.0 CA A:VAL105 3.5 61.2 1.0 O A:LEU104 3.6 59.7 1.0 CB A:THR106 3.6 57.5 1.0 N A:THR106 3.6 55.3 1.0 CB1 A:SB4401 3.6 64.4 1.0 CB A:LEU104 3.6 61.6 1.0 CB5 A:SB4401 3.6 64.0 1.0 O A:VAL105 3.7 56.5 1.0 CG2 A:THR106 3.9 58.2 1.0 CA A:LEU104 4.1 60.0 1.0 CD2 A:LEU86 4.1 57.5 1.0 CB6 A:SB4401 4.1 65.2 1.0 O A:ALA51 4.1 61.6 1.0 CA A:THR106 4.2 57.3 1.0 CB A:LYS53 4.6 73.0 1.0 OG1 A:THR106 4.6 55.0 1.0 N A:LYS53 4.7 71.0 1.0 CD1 A:LEU104 4.8 66.0 1.0 CG A:LEU104 4.9 59.0 1.0 CD1 A:LEU75 4.9 60.6 1.0

D.Thapa, C.Nichols, R.Bassi, E.D.Martin, S.Verma, M.R.Conte, V.De Santis, G.F.De Nicola, M.S.Marber. TAB1-Induced Autoactivation of P38 Alpha Mitogen-Activated Protein Kinase Is Crucially Dependent on Threonine 185. Mol. Cell. Biol. V. 38 2018.
ISSN: ESSN 1098-5549
PubMed: 29229647
DOI: 10.1128/MCB.00409-17