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Atomistry » Fluorine » PDB 5pzl-5qbz » 5pzm » |
Fluorine in PDB 5pzm: Crystal Structure of the Hepatitis C Virus NS5B Rna-Dependent Rna Polymerase in Complex with 3-[2-(4-Fluorophenyl)-3-(Methylcarbamoyl)- 1-Benzofuran-5-Yl]Benzoic AcidEnzymatic activity of Crystal Structure of the Hepatitis C Virus NS5B Rna-Dependent Rna Polymerase in Complex with 3-[2-(4-Fluorophenyl)-3-(Methylcarbamoyl)- 1-Benzofuran-5-Yl]Benzoic Acid
All present enzymatic activity of Crystal Structure of the Hepatitis C Virus NS5B Rna-Dependent Rna Polymerase in Complex with 3-[2-(4-Fluorophenyl)-3-(Methylcarbamoyl)- 1-Benzofuran-5-Yl]Benzoic Acid:
2.7.7.48; Protein crystallography data
The structure of Crystal Structure of the Hepatitis C Virus NS5B Rna-Dependent Rna Polymerase in Complex with 3-[2-(4-Fluorophenyl)-3-(Methylcarbamoyl)- 1-Benzofuran-5-Yl]Benzoic Acid, PDB code: 5pzm
was solved by
S.Sheriff,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structure of the Hepatitis C Virus NS5B Rna-Dependent Rna Polymerase in Complex with 3-[2-(4-Fluorophenyl)-3-(Methylcarbamoyl)- 1-Benzofuran-5-Yl]Benzoic Acid
(pdb code 5pzm). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Crystal Structure of the Hepatitis C Virus NS5B Rna-Dependent Rna Polymerase in Complex with 3-[2-(4-Fluorophenyl)-3-(Methylcarbamoyl)- 1-Benzofuran-5-Yl]Benzoic Acid, PDB code: 5pzm: Fluorine binding site 1 out of 1 in 5pzmGo back to Fluorine Binding Sites List in 5pzm
Fluorine binding site 1 out
of 1 in the Crystal Structure of the Hepatitis C Virus NS5B Rna-Dependent Rna Polymerase in Complex with 3-[2-(4-Fluorophenyl)-3-(Methylcarbamoyl)- 1-Benzofuran-5-Yl]Benzoic Acid
Mono view Stereo pair view
Reference:
K.S.Yeung,
B.R.Beno,
K.Parcella,
J.A.Bender,
K.A.Grant-Young,
A.Nickel,
P.Gunaga,
P.Anjanappa,
R.O.Bora,
K.Selvakumar,
K.Rigat,
Y.K.Wang,
M.Liu,
J.Lemm,
K.Mosure,
S.Sheriff,
C.Wan,
M.Witmer,
K.Kish,
U.Hanumegowda,
X.Zhuo,
Y.Z.Shu,
D.Parker,
R.Haskell,
A.Ng,
Q.Gao,
E.Colston,
J.Raybon,
D.M.Grasela,
K.Santone,
M.Gao,
N.A.Meanwell,
M.Sinz,
M.G.Soars,
J.O.Knipe,
S.B.Roberts,
J.F.Kadow.
Discovery of A Hepatitis C Virus NS5B Replicase Palm Site Allosteric Inhibitor (Bms-929075) Advanced to Phase 1 Clinical Studies. J. Med. Chem. V. 60 4369 2017.
Page generated: Sun Dec 13 12:30:57 2020
ISSN: ISSN 1520-4804 PubMed: 28430437 DOI: 10.1021/ACS.JMEDCHEM.7B00328 |
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