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Fluorine in PDB 5scx: Crystal Structure of Dihydrofolate Reductase From Mycobacterium Tuberculosis Bound to Nadp and Sddc Inhibitor Sddc-1190 (Racemic Mixture)
Enzymatic activity of Crystal Structure of Dihydrofolate Reductase From Mycobacterium Tuberculosis Bound to Nadp and Sddc Inhibitor Sddc-1190 (Racemic Mixture)
All present enzymatic activity of Crystal Structure of Dihydrofolate Reductase From Mycobacterium Tuberculosis Bound to Nadp and Sddc Inhibitor Sddc-1190 (Racemic Mixture):
1.5.1.3;
1.5.1.3;
Protein crystallography data
The structure of Crystal Structure of Dihydrofolate Reductase From Mycobacterium Tuberculosis Bound to Nadp and Sddc Inhibitor Sddc-1190 (Racemic Mixture), PDB code: 5scx
was solved by
Seattle Structural Genomics Center For Infectious Disease (Ssgcid),
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 36.15 / 1.30 |
| Space group | P 21 21 21 |
| Cell size a, b, c (Å), α, β, γ (°) | 29.28, 67.28, 72.29, 90, 90, 90 |
| R / Rfree (%) | 13.6 / 17.5 |
Other elements in 5scx:
The structure of Crystal Structure of Dihydrofolate Reductase From Mycobacterium Tuberculosis Bound to Nadp and Sddc Inhibitor Sddc-1190 (Racemic Mixture) also contains other interesting chemical elements:
| Sodium | (Na) | 1 atom |
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structure of Dihydrofolate Reductase From Mycobacterium Tuberculosis Bound to Nadp and Sddc Inhibitor Sddc-1190 (Racemic Mixture)
(pdb code 5scx). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 2 binding sites of Fluorine where determined in the Crystal Structure of Dihydrofolate Reductase From Mycobacterium Tuberculosis Bound to Nadp and Sddc Inhibitor Sddc-1190 (Racemic Mixture), PDB code: 5scx:
Jump to Fluorine binding site number: 1; 2;
In total 2 binding sites of Fluorine where determined in the Crystal Structure of Dihydrofolate Reductase From Mycobacterium Tuberculosis Bound to Nadp and Sddc Inhibitor Sddc-1190 (Racemic Mixture), PDB code: 5scx:
Jump to Fluorine binding site number: 1; 2;
Fluorine binding site 1 out of 2 in 5scx
Go back to
Fluorine Binding Sites List in 5scx
Fluorine binding site 1 out
of 2 in the Crystal Structure of Dihydrofolate Reductase From Mycobacterium Tuberculosis Bound to Nadp and Sddc Inhibitor Sddc-1190 (Racemic Mixture)
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 1 of Crystal Structure of Dihydrofolate Reductase From Mycobacterium Tuberculosis Bound to Nadp and Sddc Inhibitor Sddc-1190 (Racemic Mixture) within 5.0Å range:
|
Fluorine binding site 2 out of 2 in 5scx
Go back to
Fluorine Binding Sites List in 5scx
Fluorine binding site 2 out
of 2 in the Crystal Structure of Dihydrofolate Reductase From Mycobacterium Tuberculosis Bound to Nadp and Sddc Inhibitor Sddc-1190 (Racemic Mixture)
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 2 of Crystal Structure of Dihydrofolate Reductase From Mycobacterium Tuberculosis Bound to Nadp and Sddc Inhibitor Sddc-1190 (Racemic Mixture) within 5.0Å range:
|
Reference:
S.J.Mayclin,
D.G.Conrady,
D.D.Lorimer.
Crystal Structure of Dihydrofolate Reductase From Mycobacterium Tuberculosis Bound to Nadp and Sddc Inhibitor Sddc-1190 (Racemic Mixture) To Be Published.
Page generated: Tue Jul 15 07:08:22 2025
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