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Fluorine in PDB 5sd9: Crystal Structure of Dihydrofolate Reductase From Homo Sapiens Bound to Nadp and Sddc Inhibitor Sddc-1096

Enzymatic activity of Crystal Structure of Dihydrofolate Reductase From Homo Sapiens Bound to Nadp and Sddc Inhibitor Sddc-1096

All present enzymatic activity of Crystal Structure of Dihydrofolate Reductase From Homo Sapiens Bound to Nadp and Sddc Inhibitor Sddc-1096:
1.5.1.3;

Protein crystallography data

The structure of Crystal Structure of Dihydrofolate Reductase From Homo Sapiens Bound to Nadp and Sddc Inhibitor Sddc-1096, PDB code: 5sd9 was solved by Seattle Structural Genomics Center For Infectious Disease (Ssgcid), with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 49.40 / 2.10
Space group P 43 21 2
Cell size a, b, c (Å), α, β, γ (°) 74.35, 74.35, 144.28, 90, 90, 90
R / Rfree (%) 15.8 / 18.4

Fluorine Binding Sites:

The binding sites of Fluorine atom in the Crystal Structure of Dihydrofolate Reductase From Homo Sapiens Bound to Nadp and Sddc Inhibitor Sddc-1096 (pdb code 5sd9). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Crystal Structure of Dihydrofolate Reductase From Homo Sapiens Bound to Nadp and Sddc Inhibitor Sddc-1096, PDB code: 5sd9:

Fluorine binding site 1 out of 1 in 5sd9

Go back to Fluorine Binding Sites List in 5sd9
Fluorine binding site 1 out of 1 in the Crystal Structure of Dihydrofolate Reductase From Homo Sapiens Bound to Nadp and Sddc Inhibitor Sddc-1096


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Crystal Structure of Dihydrofolate Reductase From Homo Sapiens Bound to Nadp and Sddc Inhibitor Sddc-1096 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:F202

b:58.1
occ:1.00
 F25 A:HZU202 0.0 58.1 1.0
C24 A:HZU202 1.4 56.2 1.0
C23 A:HZU202 2.4 63.1 1.0
O A:HOH341 2.6 41.2 1.0
C22 A:HZU202 2.7 56.0 1.0
O27 A:HZU202 3.2 81.7 1.0
C26 A:HZU202 3.3 74.0 1.0
OD1 A:ASP22 3.4 56.4 0.9
O A:HOH338 3.4 51.7 1.0
O A:SER60 3.7 34.9 1.0
O2D A:NAP201 4.1 26.6 0.9
CG A:LEU23 4.2 35.4 1.0
C21 A:HZU202 4.2 49.0 1.0
O A:HOH302 4.3 51.8 1.0
CG A:ASP22 4.3 58.5 0.8
N A:LEU23 4.3 26.9 1.0
OG A:SER60 4.3 38.3 1.0
CA A:ASP22 4.4 32.2 1.0
O28 A:HZU202 4.5 79.3 1.0
C A:SER60 4.5 37.3 1.0
CB A:SER60 4.6 36.9 1.0
O15 A:HZU202 4.6 43.8 1.0
CD2 A:LEU23 4.7 31.9 1.0
C A:ASP22 4.7 32.7 1.0
CD1 A:LEU23 4.8 26.2 1.0
O A:GLY21 4.8 37.6 1.0
C16 A:HZU202 5.0 40.7 1.0

Reference:

S.J.Mayclin, J.W.Fairman, D.M.Dranow, D.G.Conrady, D.Fox Iii, C.M.Lukacs, D.D.Lorimer, P.S.Horanyi, T.E.Edwards, J.Abendroth. Crystal Structure of Dihydrofolate Reductase From Homo Sapiens Bound to Nadp and Sddc Inhibitor Sddc-1096 To Be Published.
Page generated: Tue Apr 4 23:41:52 2023

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