Atomistry » Fluorine » PDB 5sb0-5sjo » 5sd9
Atomistry »
  Fluorine »
    PDB 5sb0-5sjo »
      5sd9 »

Fluorine in PDB 5sd9: Crystal Structure of Dihydrofolate Reductase From Homo Sapiens Bound to Nadp and Sddc Inhibitor Sddc-1096

Enzymatic activity of Crystal Structure of Dihydrofolate Reductase From Homo Sapiens Bound to Nadp and Sddc Inhibitor Sddc-1096

All present enzymatic activity of Crystal Structure of Dihydrofolate Reductase From Homo Sapiens Bound to Nadp and Sddc Inhibitor Sddc-1096:
1.5.1.3;

Protein crystallography data

The structure of Crystal Structure of Dihydrofolate Reductase From Homo Sapiens Bound to Nadp and Sddc Inhibitor Sddc-1096, PDB code: 5sd9 was solved by Seattle Structural Genomics Center For Infectious Disease (Ssgcid), with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 49.40 / 2.10
Space group P 43 21 2
Cell size a, b, c (Å), α, β, γ (°) 74.35, 74.35, 144.28, 90, 90, 90
R / Rfree (%) 15.8 / 18.4

Fluorine Binding Sites:

The binding sites of Fluorine atom in the Crystal Structure of Dihydrofolate Reductase From Homo Sapiens Bound to Nadp and Sddc Inhibitor Sddc-1096 (pdb code 5sd9). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Crystal Structure of Dihydrofolate Reductase From Homo Sapiens Bound to Nadp and Sddc Inhibitor Sddc-1096, PDB code: 5sd9:

Fluorine binding site 1 out of 1 in 5sd9

Go back to Fluorine Binding Sites List in 5sd9
Fluorine binding site 1 out of 1 in the Crystal Structure of Dihydrofolate Reductase From Homo Sapiens Bound to Nadp and Sddc Inhibitor Sddc-1096


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Crystal Structure of Dihydrofolate Reductase From Homo Sapiens Bound to Nadp and Sddc Inhibitor Sddc-1096 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:F202

b:58.1
occ:1.00
 F25 A:HZU202 0.0 58.1 1.0
C24 A:HZU202 1.4 56.2 1.0
C23 A:HZU202 2.4 63.1 1.0
O A:HOH341 2.6 41.2 1.0
C22 A:HZU202 2.7 56.0 1.0
O27 A:HZU202 3.2 81.7 1.0
C26 A:HZU202 3.3 74.0 1.0
OD1 A:ASP22 3.4 56.4 0.9
O A:HOH338 3.4 51.7 1.0
O A:SER60 3.7 34.9 1.0
O2D A:NAP201 4.1 26.6 0.9
CG A:LEU23 4.2 35.4 1.0
C21 A:HZU202 4.2 49.0 1.0
O A:HOH302 4.3 51.8 1.0
CG A:ASP22 4.3 58.5 0.8
N A:LEU23 4.3 26.9 1.0
OG A:SER60 4.3 38.3 1.0
CA A:ASP22 4.4 32.2 1.0
O28 A:HZU202 4.5 79.3 1.0
C A:SER60 4.5 37.3 1.0
CB A:SER60 4.6 36.9 1.0
O15 A:HZU202 4.6 43.8 1.0
CD2 A:LEU23 4.7 31.9 1.0
C A:ASP22 4.7 32.7 1.0
CD1 A:LEU23 4.8 26.2 1.0
O A:GLY21 4.8 37.6 1.0
C16 A:HZU202 5.0 40.7 1.0

Reference:

S.J.Mayclin, J.W.Fairman, D.M.Dranow, D.G.Conrady, D.Fox Iii, C.M.Lukacs, D.D.Lorimer, P.S.Horanyi, T.E.Edwards, J.Abendroth. Crystal Structure of Dihydrofolate Reductase From Homo Sapiens Bound to Nadp and Sddc Inhibitor Sddc-1096 To Be Published.
Page generated: Thu Aug 1 14:13:19 2024

Last articles

Zn in 9JPJ
Zn in 9JP7
Zn in 9JPK
Zn in 9JPL
Zn in 9GN6
Zn in 9GN7
Zn in 9GKU
Zn in 9GKW
Zn in 9GKX
Zn in 9GL0
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy