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Fluorine in PDB 5tbe: Human P38ALPHA Map Kinase in Complex with Dibenzosuberone Compound 2Enzymatic activity of Human P38ALPHA Map Kinase in Complex with Dibenzosuberone Compound 2
All present enzymatic activity of Human P38ALPHA Map Kinase in Complex with Dibenzosuberone Compound 2:
2.7.11.24; Protein crystallography data
The structure of Human P38ALPHA Map Kinase in Complex with Dibenzosuberone Compound 2, PDB code: 5tbe
was solved by
M.Buehrmann,
D.Rauh,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Human P38ALPHA Map Kinase in Complex with Dibenzosuberone Compound 2
(pdb code 5tbe). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 2 binding sites of Fluorine where determined in the Human P38ALPHA Map Kinase in Complex with Dibenzosuberone Compound 2, PDB code: 5tbe: Jump to Fluorine binding site number: 1; 2; Fluorine binding site 1 out of 2 in 5tbeGo back to Fluorine Binding Sites List in 5tbe
Fluorine binding site 1 out
of 2 in the Human P38ALPHA Map Kinase in Complex with Dibenzosuberone Compound 2
Mono view Stereo pair view
Fluorine binding site 2 out of 2 in 5tbeGo back to Fluorine Binding Sites List in 5tbe
Fluorine binding site 2 out
of 2 in the Human P38ALPHA Map Kinase in Complex with Dibenzosuberone Compound 2
Mono view Stereo pair view
Reference:
H.K.Wentsch,
N.M.Walter,
M.Buhrmann,
S.Mayer-Wrangowski,
D.Rauh,
G.J.R.Zaman,
N.Willemsen-Seegers,
R.C.Buijsman,
M.Henning,
D.Dauch,
L.Zender,
S.Laufer.
Optimized Target Residence Time: Type I1/2 Inhibitors For P38 Alpha Map Kinase with Improved Binding Kinetics Through Direct Interaction with the R-Spine. Angew. Chem. Int. Ed. Engl. V. 56 5363 2017.
Page generated: Sun Dec 13 12:37:52 2020
ISSN: ESSN 1521-3773 PubMed: 28397331 DOI: 10.1002/ANIE.201701185 |
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