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Fluorine in PDB 5tbo: Crystal Structure of Plasmodium Falciparum Dihydroorotate Dehydrogenase Bound with Inhibitor DSM421
Enzymatic activity of Crystal Structure of Plasmodium Falciparum Dihydroorotate Dehydrogenase Bound with Inhibitor DSM421
All present enzymatic activity of Crystal Structure of Plasmodium Falciparum Dihydroorotate Dehydrogenase Bound with Inhibitor DSM421:
1.3.5.2;
1.3.5.2;
Protein crystallography data
The structure of Crystal Structure of Plasmodium Falciparum Dihydroorotate Dehydrogenase Bound with Inhibitor DSM421, PDB code: 5tbo
was solved by
X.Deng,
M.Phillips,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 31.55 / 2.15 |
| Space group | P 64 |
| Cell size a, b, c (Å), α, β, γ (°) | 86.380, 86.380, 138.608, 90.00, 90.00, 120.00 |
| R / Rfree (%) | 18.1 / 21.9 |
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structure of Plasmodium Falciparum Dihydroorotate Dehydrogenase Bound with Inhibitor DSM421
(pdb code 5tbo). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 5 binding sites of Fluorine where determined in the Crystal Structure of Plasmodium Falciparum Dihydroorotate Dehydrogenase Bound with Inhibitor DSM421, PDB code: 5tbo:
Jump to Fluorine binding site number: 1; 2; 3; 4; 5;
In total 5 binding sites of Fluorine where determined in the Crystal Structure of Plasmodium Falciparum Dihydroorotate Dehydrogenase Bound with Inhibitor DSM421, PDB code: 5tbo:
Jump to Fluorine binding site number: 1; 2; 3; 4; 5;
Fluorine binding site 1 out of 5 in 5tbo
Go back to
Fluorine Binding Sites List in 5tbo
Fluorine binding site 1 out
of 5 in the Crystal Structure of Plasmodium Falciparum Dihydroorotate Dehydrogenase Bound with Inhibitor DSM421
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 1 of Crystal Structure of Plasmodium Falciparum Dihydroorotate Dehydrogenase Bound with Inhibitor DSM421 within 5.0Å range:
|
Fluorine binding site 2 out of 5 in 5tbo
Go back to
Fluorine Binding Sites List in 5tbo
Fluorine binding site 2 out
of 5 in the Crystal Structure of Plasmodium Falciparum Dihydroorotate Dehydrogenase Bound with Inhibitor DSM421
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 2 of Crystal Structure of Plasmodium Falciparum Dihydroorotate Dehydrogenase Bound with Inhibitor DSM421 within 5.0Å range:
|
Fluorine binding site 3 out of 5 in 5tbo
Go back to
Fluorine Binding Sites List in 5tbo
Fluorine binding site 3 out
of 5 in the Crystal Structure of Plasmodium Falciparum Dihydroorotate Dehydrogenase Bound with Inhibitor DSM421
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 3 of Crystal Structure of Plasmodium Falciparum Dihydroorotate Dehydrogenase Bound with Inhibitor DSM421 within 5.0Å range:
|
Fluorine binding site 4 out of 5 in 5tbo
Go back to
Fluorine Binding Sites List in 5tbo
Fluorine binding site 4 out
of 5 in the Crystal Structure of Plasmodium Falciparum Dihydroorotate Dehydrogenase Bound with Inhibitor DSM421
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 4 of Crystal Structure of Plasmodium Falciparum Dihydroorotate Dehydrogenase Bound with Inhibitor DSM421 within 5.0Å range:
|
Fluorine binding site 5 out of 5 in 5tbo
Go back to
Fluorine Binding Sites List in 5tbo
Fluorine binding site 5 out
of 5 in the Crystal Structure of Plasmodium Falciparum Dihydroorotate Dehydrogenase Bound with Inhibitor DSM421
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 5 of Crystal Structure of Plasmodium Falciparum Dihydroorotate Dehydrogenase Bound with Inhibitor DSM421 within 5.0Å range:
|
Reference:
M.A.Phillips,
K.L.White,
S.Kokkonda,
X.Deng,
J.White,
F.El Mazouni,
K.Marsh,
D.R.Tomchick,
K.Manjalanagara,
K.R.Rudra,
G.Wirjanata,
R.Noviyanti,
R.N.Price,
J.Marfurt,
D.M.Shackleford,
F.C.Chiu,
M.Campbell,
M.B.Jimenez-Diaz,
S.F.Bazaga,
I.Angulo-Barturen,
M.S.Martinez,
M.Lafuente-Monasterio,
W.Kaminsky,
K.Silue,
A.M.Zeeman,
C.Kocken,
D.Leroy,
B.Blasco,
E.Rossignol,
T.Rueckle,
D.Matthews,
J.N.Burrows,
D.Waterson,
M.J.Palmer,
P.K.Rathod,
S.A.Charman.
A Triazolopyrimidine-Based Dihydroorotate Dehydrogenase Inhibitor with Improved Drug-Like Properties For Treatment and Prevention of Malaria. Acs Infect Dis V. 2 945 2016.
ISSN: ESSN 2373-8227
PubMed: 27641613
DOI: 10.1021/ACSINFECDIS.6B00144
Page generated: Thu Aug 1 15:10:05 2024
ISSN: ESSN 2373-8227
PubMed: 27641613
DOI: 10.1021/ACSINFECDIS.6B00144
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