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Atomistry » Fluorine » PDB 5tbm-5tto » 5tm1 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Fluorine » PDB 5tbm-5tto » 5tm1 » |
Fluorine in PDB 5tm1: Crystal Structure of the Er-Alpha Ligand-Binding Domain (Y537S) in Complex with 2,5-Bis(2-Fluoro-4-Hydroxyphenyl)Thiophene 1-OxideProtein crystallography data
The structure of Crystal Structure of the Er-Alpha Ligand-Binding Domain (Y537S) in Complex with 2,5-Bis(2-Fluoro-4-Hydroxyphenyl)Thiophene 1-Oxide, PDB code: 5tm1
was solved by
J.C.Nwachukwu,
N.J.Wright,
S.Srinivasan,
N.E.Bruno,
J.Nowak,
D.J.Kojetin,
O.Elemento,
J.A.Katzenellenbogen,
K.W.Nettles,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structure of the Er-Alpha Ligand-Binding Domain (Y537S) in Complex with 2,5-Bis(2-Fluoro-4-Hydroxyphenyl)Thiophene 1-Oxide
(pdb code 5tm1). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 4 binding sites of Fluorine where determined in the Crystal Structure of the Er-Alpha Ligand-Binding Domain (Y537S) in Complex with 2,5-Bis(2-Fluoro-4-Hydroxyphenyl)Thiophene 1-Oxide, PDB code: 5tm1: Jump to Fluorine binding site number: 1; 2; 3; 4; Fluorine binding site 1 out of 4 in 5tm1Go back to Fluorine Binding Sites List in 5tm1
Fluorine binding site 1 out
of 4 in the Crystal Structure of the Er-Alpha Ligand-Binding Domain (Y537S) in Complex with 2,5-Bis(2-Fluoro-4-Hydroxyphenyl)Thiophene 1-Oxide
Mono view Stereo pair view
Fluorine binding site 2 out of 4 in 5tm1Go back to Fluorine Binding Sites List in 5tm1
Fluorine binding site 2 out
of 4 in the Crystal Structure of the Er-Alpha Ligand-Binding Domain (Y537S) in Complex with 2,5-Bis(2-Fluoro-4-Hydroxyphenyl)Thiophene 1-Oxide
Mono view Stereo pair view
Fluorine binding site 3 out of 4 in 5tm1Go back to Fluorine Binding Sites List in 5tm1
Fluorine binding site 3 out
of 4 in the Crystal Structure of the Er-Alpha Ligand-Binding Domain (Y537S) in Complex with 2,5-Bis(2-Fluoro-4-Hydroxyphenyl)Thiophene 1-Oxide
Mono view Stereo pair view
Fluorine binding site 4 out of 4 in 5tm1Go back to Fluorine Binding Sites List in 5tm1
Fluorine binding site 4 out
of 4 in the Crystal Structure of the Er-Alpha Ligand-Binding Domain (Y537S) in Complex with 2,5-Bis(2-Fluoro-4-Hydroxyphenyl)Thiophene 1-Oxide
Mono view Stereo pair view
Reference:
J.C.Nwachukwu,
S.Srinivasan,
N.E.Bruno,
J.Nowak,
N.J.Wright,
F.Minutolo,
E.S.Rangarajan,
T.Izard,
X.Q.Yao,
B.J.Grant,
D.J.Kojetin,
O.Elemento,
J.A.Katzenellenbogen,
K.W.Nettles.
Systems Structural Biology Analysis of Ligand Effects on Er Alpha Predicts Cellular Response to Environmental Estrogens and Anti-Hormone Therapies. Cell Chem Biol V. 24 35 2017.
Page generated: Thu Aug 1 15:15:27 2024
ISSN: ESSN 2451-9456 PubMed: 28042045 DOI: 10.1016/J.CHEMBIOL.2016.11.014 |
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