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Atomistry » Fluorine » PDB 5tbm-5tto » 5tqh | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Fluorine » PDB 5tbm-5tto » 5tqh » |
Fluorine in PDB 5tqh: IDH1 R132H Mutant in Complex with IDH889Enzymatic activity of IDH1 R132H Mutant in Complex with IDH889
All present enzymatic activity of IDH1 R132H Mutant in Complex with IDH889:
1.1.1.42; Protein crystallography data
The structure of IDH1 R132H Mutant in Complex with IDH889, PDB code: 5tqh
was solved by
X.Xie,
R.Kulathila,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the IDH1 R132H Mutant in Complex with IDH889
(pdb code 5tqh). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 4 binding sites of Fluorine where determined in the IDH1 R132H Mutant in Complex with IDH889, PDB code: 5tqh: Jump to Fluorine binding site number: 1; 2; 3; 4; Fluorine binding site 1 out of 4 in 5tqhGo back to![]() ![]()
Fluorine binding site 1 out
of 4 in the IDH1 R132H Mutant in Complex with IDH889
![]() Mono view ![]() Stereo pair view
Fluorine binding site 2 out of 4 in 5tqhGo back to![]() ![]()
Fluorine binding site 2 out
of 4 in the IDH1 R132H Mutant in Complex with IDH889
![]() Mono view ![]() Stereo pair view
Fluorine binding site 3 out of 4 in 5tqhGo back to![]() ![]()
Fluorine binding site 3 out
of 4 in the IDH1 R132H Mutant in Complex with IDH889
![]() Mono view ![]() Stereo pair view
Fluorine binding site 4 out of 4 in 5tqhGo back to![]() ![]()
Fluorine binding site 4 out
of 4 in the IDH1 R132H Mutant in Complex with IDH889
![]() Mono view ![]() Stereo pair view
Reference:
J.R.Levell,
T.Caferro,
G.Chenail,
I.Dix,
J.Dooley,
B.Firestone,
P.D.Fortin,
J.Giraldes,
T.Gould,
J.D.Growney,
M.D.Jones,
R.Kulathila,
F.Lin,
G.Liu,
A.Mueller,
S.Van Der Plas,
K.Slocum,
T.Smith,
R.Terranova,
B.B.Toure,
V.Tyagi,
T.Wagner,
X.Xie,
M.Xu,
F.S.Yang,
L.X.Zhou,
R.Pagliarini,
Y.S.Cho.
Optimization of 3-Pyrimidin-4-Yl-Oxazolidin-2-Ones As Allosteric and Mutant Specific Inhibitors of IDH1. Acs Med Chem Lett V. 8 151 2017.
Page generated: Thu Aug 1 15:20:38 2024
ISSN: ISSN 1948-5875 PubMed: 28197303 DOI: 10.1021/ACSMEDCHEMLETT.6B00334 |
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