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Fluorine in PDB 5tr6: Discovery of Tak-659, An Orally Available Investigational Inhibitor of Spleen Tyrosine Kinase (Syk)Enzymatic activity of Discovery of Tak-659, An Orally Available Investigational Inhibitor of Spleen Tyrosine Kinase (Syk)
All present enzymatic activity of Discovery of Tak-659, An Orally Available Investigational Inhibitor of Spleen Tyrosine Kinase (Syk):
2.7.10.2; Protein crystallography data
The structure of Discovery of Tak-659, An Orally Available Investigational Inhibitor of Spleen Tyrosine Kinase (Syk), PDB code: 5tr6
was solved by
J.Yano,
A.Jennings,
B.Lam,
I.D.Hoffman,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Discovery of Tak-659, An Orally Available Investigational Inhibitor of Spleen Tyrosine Kinase (Syk)
(pdb code 5tr6). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Discovery of Tak-659, An Orally Available Investigational Inhibitor of Spleen Tyrosine Kinase (Syk), PDB code: 5tr6: Fluorine binding site 1 out of 1 in 5tr6Go back to Fluorine Binding Sites List in 5tr6
Fluorine binding site 1 out
of 1 in the Discovery of Tak-659, An Orally Available Investigational Inhibitor of Spleen Tyrosine Kinase (Syk)
Mono view Stereo pair view
Reference:
B.Lam,
Y.Arikawa,
J.Cramlett,
Q.Dong,
R.De Jong,
V.Feher,
C.E.Grimshaw,
P.J.Farrell,
I.D.Hoffman,
A.Jennings,
B.Jones,
J.Matuszkiewicz,
J.Miura,
H.Miyake,
S.R.Natala,
L.Shi,
M.Takahashi,
E.Taylor,
C.Wyrick,
J.Yano,
J.Zalevsky,
Z.Nie.
Discovery of Tak-659 An Orally Available Investigational Inhibitor of Spleen Tyrosine Kinase (Syk). Bioorg. Med. Chem. Lett. V. 26 5947 2016.
Page generated: Sun Dec 13 12:38:27 2020
ISSN: ESSN 1464-3405 PubMed: 27839918 DOI: 10.1016/J.BMCL.2016.10.087 |
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