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Atomistry » Fluorine » PDB 5tvj-5ug2 » 5twn » |
Fluorine in PDB 5twn: Crystal Structure of the Hepatitis C Virus NS5B Rna- Dependent Rna Polymerase in Complex with 5-[3-(Tert-Butylcarbamoyl)Phenyl]-6- (Ethylamino)-2-(4-Fluorophenyl)-N-Methylfuro[2,3-B]Pyridine-3- CarboxamideEnzymatic activity of Crystal Structure of the Hepatitis C Virus NS5B Rna- Dependent Rna Polymerase in Complex with 5-[3-(Tert-Butylcarbamoyl)Phenyl]-6- (Ethylamino)-2-(4-Fluorophenyl)-N-Methylfuro[2,3-B]Pyridine-3- Carboxamide
All present enzymatic activity of Crystal Structure of the Hepatitis C Virus NS5B Rna- Dependent Rna Polymerase in Complex with 5-[3-(Tert-Butylcarbamoyl)Phenyl]-6- (Ethylamino)-2-(4-Fluorophenyl)-N-Methylfuro[2,3-B]Pyridine-3- Carboxamide:
2.7.7.48; Protein crystallography data
The structure of Crystal Structure of the Hepatitis C Virus NS5B Rna- Dependent Rna Polymerase in Complex with 5-[3-(Tert-Butylcarbamoyl)Phenyl]-6- (Ethylamino)-2-(4-Fluorophenyl)-N-Methylfuro[2,3-B]Pyridine-3- Carboxamide, PDB code: 5twn
was solved by
S.Sheriff,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structure of the Hepatitis C Virus NS5B Rna- Dependent Rna Polymerase in Complex with 5-[3-(Tert-Butylcarbamoyl)Phenyl]-6- (Ethylamino)-2-(4-Fluorophenyl)-N-Methylfuro[2,3-B]Pyridine-3- Carboxamide
(pdb code 5twn). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Crystal Structure of the Hepatitis C Virus NS5B Rna- Dependent Rna Polymerase in Complex with 5-[3-(Tert-Butylcarbamoyl)Phenyl]-6- (Ethylamino)-2-(4-Fluorophenyl)-N-Methylfuro[2,3-B]Pyridine-3- Carboxamide, PDB code: 5twn: Fluorine binding site 1 out of 1 in 5twnGo back to![]() ![]()
Fluorine binding site 1 out
of 1 in the Crystal Structure of the Hepatitis C Virus NS5B Rna- Dependent Rna Polymerase in Complex with 5-[3-(Tert-Butylcarbamoyl)Phenyl]-6- (Ethylamino)-2-(4-Fluorophenyl)-N-Methylfuro[2,3-B]Pyridine-3- Carboxamide
![]() Mono view ![]() Stereo pair view
Reference:
K.J.Eastman,
K.Parcella,
K.S.Yeung,
K.A.Grant-Young,
J.Zhu,
T.Wang,
Z.Zhang,
Z.Yin,
B.R.Beno,
S.Sheriff,
K.Kish,
J.Tredup,
A.G.Jardel,
V.Halan,
K.Ghosh,
D.Parker,
K.Mosure,
H.Fang,
Y.K.Wang,
J.Lemm,
X.Zhuo,
U.Hanumegowda,
K.Rigat,
M.Donoso,
M.Tuttle,
T.Zvyaga,
Z.Haarhoff,
N.A.Meanwell,
M.G.Soars,
S.B.Roberts,
J.F.Kadow.
The Discovery of A Pan-Genotypic, Primer Grip Inhibitor of Hcv NS5B Polymerase. Medchemcomm V. 8 796 2017.
Page generated: Thu Aug 1 15:27:11 2024
ISSN: ISSN 2040-2503 PubMed: 30108798 DOI: 10.1039/C6MD00636A |
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