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Fluorine in PDB 5u5h: Crystal Structure of Eed in Complex with 6-(2-Fluoro-5-Methoxybenzyl)- 1-Isopropyl-5,6,7,8-Tetrahydroimidazo[1,5-A]Pyridin-3-Amine 6-(2- Fluoro-5-Methoxybenzyl)-1-Isopropyl-5,6,7,8-Tetrahydroimidazo[1,5- A]Pyridin-3-AmineProtein crystallography data
The structure of Crystal Structure of Eed in Complex with 6-(2-Fluoro-5-Methoxybenzyl)- 1-Isopropyl-5,6,7,8-Tetrahydroimidazo[1,5-A]Pyridin-3-Amine 6-(2- Fluoro-5-Methoxybenzyl)-1-Isopropyl-5,6,7,8-Tetrahydroimidazo[1,5- A]Pyridin-3-Amine, PDB code: 5u5h
was solved by
D.Bussiere,
W.Shu,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structure of Eed in Complex with 6-(2-Fluoro-5-Methoxybenzyl)- 1-Isopropyl-5,6,7,8-Tetrahydroimidazo[1,5-A]Pyridin-3-Amine 6-(2- Fluoro-5-Methoxybenzyl)-1-Isopropyl-5,6,7,8-Tetrahydroimidazo[1,5- A]Pyridin-3-Amine
(pdb code 5u5h). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Crystal Structure of Eed in Complex with 6-(2-Fluoro-5-Methoxybenzyl)- 1-Isopropyl-5,6,7,8-Tetrahydroimidazo[1,5-A]Pyridin-3-Amine 6-(2- Fluoro-5-Methoxybenzyl)-1-Isopropyl-5,6,7,8-Tetrahydroimidazo[1,5- A]Pyridin-3-Amine, PDB code: 5u5h: Fluorine binding site 1 out of 1 in 5u5hGo back to Fluorine Binding Sites List in 5u5h
Fluorine binding site 1 out
of 1 in the Crystal Structure of Eed in Complex with 6-(2-Fluoro-5-Methoxybenzyl)- 1-Isopropyl-5,6,7,8-Tetrahydroimidazo[1,5-A]Pyridin-3-Amine 6-(2- Fluoro-5-Methoxybenzyl)-1-Isopropyl-5,6,7,8-Tetrahydroimidazo[1,5- A]Pyridin-3-Amine
Mono view Stereo pair view
Reference:
A.Lingel,
M.Sendzik,
Y.Huang,
M.D.Shultz,
J.Cantwell,
M.P.Dillon,
X.Fu,
J.Fuller,
T.Gabriel,
J.Gu,
X.Jiang,
L.Li,
F.Liang,
M.Mckenna,
W.Qi,
W.Rao,
X.Sheng,
W.Shu,
J.Sutton,
B.Taft,
L.Wang,
J.Zeng,
H.Zhang,
M.Zhang,
K.Zhao,
M.Lindvall,
D.E.Bussiere.
Structure-Guided Design of Eed Binders Allosterically Inhibiting the Epigenetic Polycomb Repressive Complex 2 (PRC2) Methyltransferase. J. Med. Chem. V. 60 415 2017.
Page generated: Sun Dec 13 12:39:00 2020
ISSN: ISSN 1520-4804 PubMed: 27992714 DOI: 10.1021/ACS.JMEDCHEM.6B01473 |
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