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Fluorine in PDB 5u6d: Polycomb Protein Eed in Complex with Inhibitor: 2-[4-(4-{(3S,4R)-4- (Dimethylamino)-1-[(2-Fluoro-6-Methylphenyl)Methyl]Pyrrolidin-3- Yl}Phenyl)-1H-Pyrazol-1-Yl]AcetamideProtein crystallography data
The structure of Polycomb Protein Eed in Complex with Inhibitor: 2-[4-(4-{(3S,4R)-4- (Dimethylamino)-1-[(2-Fluoro-6-Methylphenyl)Methyl]Pyrrolidin-3- Yl}Phenyl)-1H-Pyrazol-1-Yl]Acetamide, PDB code: 5u6d
was solved by
C.G.Jakob,
H.Zhu,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Polycomb Protein Eed in Complex with Inhibitor: 2-[4-(4-{(3S,4R)-4- (Dimethylamino)-1-[(2-Fluoro-6-Methylphenyl)Methyl]Pyrrolidin-3- Yl}Phenyl)-1H-Pyrazol-1-Yl]Acetamide
(pdb code 5u6d). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Polycomb Protein Eed in Complex with Inhibitor: 2-[4-(4-{(3S,4R)-4- (Dimethylamino)-1-[(2-Fluoro-6-Methylphenyl)Methyl]Pyrrolidin-3- Yl}Phenyl)-1H-Pyrazol-1-Yl]Acetamide, PDB code: 5u6d: Fluorine binding site 1 out of 1 in 5u6dGo back to Fluorine Binding Sites List in 5u6d
Fluorine binding site 1 out
of 1 in the Polycomb Protein Eed in Complex with Inhibitor: 2-[4-(4-{(3S,4R)-4- (Dimethylamino)-1-[(2-Fluoro-6-Methylphenyl)Methyl]Pyrrolidin-3- Yl}Phenyl)-1H-Pyrazol-1-Yl]Acetamide
Mono view Stereo pair view
Reference:
M.L.Curtin,
M.A.Pliushchev,
H.Q.Li,
M.Torrent,
J.D.Dietrich,
C.G.Jakob,
H.Zhu,
H.Zhao,
Y.Wang,
Z.Ji,
R.F.Clark,
K.A.Sarris,
S.Selvaraju,
B.Shaw,
M.A.Algire,
Y.He,
P.L.Richardson,
R.F.Sweis,
C.Sun,
G.G.Chiang,
M.R.Michaelides.
Sar of Amino Pyrrolidines As Potent and Novel Protein-Protein Interaction Inhibitors of the PRC2 Complex Through Eed Binding. Bioorg. Med. Chem. Lett. V. 27 1576 2017.
Page generated: Sun Dec 13 12:39:03 2020
ISSN: ESSN 1464-3405 PubMed: 28254486 DOI: 10.1016/J.BMCL.2017.02.030 |
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