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Fluorine in PDB 5upf: Crystal Structure of Human Nampt with Isoindoline Urea Inhibitor Compound 53Enzymatic activity of Crystal Structure of Human Nampt with Isoindoline Urea Inhibitor Compound 53
All present enzymatic activity of Crystal Structure of Human Nampt with Isoindoline Urea Inhibitor Compound 53:
2.4.2.12; Protein crystallography data
The structure of Crystal Structure of Human Nampt with Isoindoline Urea Inhibitor Compound 53, PDB code: 5upf
was solved by
K.L.Longenecker,
D.Raich,
A.V.Korepanova,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structure of Human Nampt with Isoindoline Urea Inhibitor Compound 53
(pdb code 5upf). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 2 binding sites of Fluorine where determined in the Crystal Structure of Human Nampt with Isoindoline Urea Inhibitor Compound 53, PDB code: 5upf: Jump to Fluorine binding site number: 1; 2; Fluorine binding site 1 out of 2 in 5upfGo back to Fluorine Binding Sites List in 5upf
Fluorine binding site 1 out
of 2 in the Crystal Structure of Human Nampt with Isoindoline Urea Inhibitor Compound 53
Mono view Stereo pair view
Fluorine binding site 2 out of 2 in 5upfGo back to Fluorine Binding Sites List in 5upf
Fluorine binding site 2 out
of 2 in the Crystal Structure of Human Nampt with Isoindoline Urea Inhibitor Compound 53
Mono view Stereo pair view
Reference:
M.L.Curtin,
H.R.Heyman,
R.F.Clark,
B.K.Sorensen,
G.A.Doherty,
T.M.Hansen,
R.R.Frey,
K.A.Sarris,
A.L.Aguirre,
A.Shrestha,
N.Tu,
K.Woller,
M.A.Pliushchev,
R.F.Sweis,
M.Cheng,
J.L.Wilsbacher,
P.J.Kovar,
J.Guo,
D.Cheng,
K.L.Longenecker,
D.Raich,
A.V.Korepanova,
N.B.Soni,
M.A.Algire,
P.L.Richardson,
V.L.Marin,
I.Badagnani,
A.Vasudevan,
F.G.Buchanan,
D.Maag,
G.G.Chiang,
C.Tse,
M.R.Michaelides.
Sar and Characterization of Non-Substrate Isoindoline Urea Inhibitors of Nicotinamide Phosphoribosyltransferase (Nampt). Bioorg. Med. Chem. Lett. V. 27 3317 2017.
Page generated: Sun Dec 13 12:39:35 2020
ISSN: ESSN 1464-3405 PubMed: 28610984 DOI: 10.1016/J.BMCL.2017.06.018 |
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