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Atomistry » Fluorine » PDB 5uv3-5vd4 » 5uwd | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Fluorine » PDB 5uv3-5vd4 » 5uwd » |
Fluorine in PDB 5uwd: Crystal Structure of Egfr Kinase Domain (L858R, T790M, V948R) in Complex with the Covalent Inhibitor Co-1686Enzymatic activity of Crystal Structure of Egfr Kinase Domain (L858R, T790M, V948R) in Complex with the Covalent Inhibitor Co-1686
All present enzymatic activity of Crystal Structure of Egfr Kinase Domain (L858R, T790M, V948R) in Complex with the Covalent Inhibitor Co-1686:
2.7.10.1; Protein crystallography data
The structure of Crystal Structure of Egfr Kinase Domain (L858R, T790M, V948R) in Complex with the Covalent Inhibitor Co-1686, PDB code: 5uwd
was solved by
K.S.Gajiwala,
R.A.Ferre,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structure of Egfr Kinase Domain (L858R, T790M, V948R) in Complex with the Covalent Inhibitor Co-1686
(pdb code 5uwd). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 3 binding sites of Fluorine where determined in the Crystal Structure of Egfr Kinase Domain (L858R, T790M, V948R) in Complex with the Covalent Inhibitor Co-1686, PDB code: 5uwd: Jump to Fluorine binding site number: 1; 2; 3; Fluorine binding site 1 out of 3 in 5uwdGo back to![]() ![]()
Fluorine binding site 1 out
of 3 in the Crystal Structure of Egfr Kinase Domain (L858R, T790M, V948R) in Complex with the Covalent Inhibitor Co-1686
![]() Mono view ![]() Stereo pair view
Fluorine binding site 2 out of 3 in 5uwdGo back to![]() ![]()
Fluorine binding site 2 out
of 3 in the Crystal Structure of Egfr Kinase Domain (L858R, T790M, V948R) in Complex with the Covalent Inhibitor Co-1686
![]() Mono view ![]() Stereo pair view
Fluorine binding site 3 out of 3 in 5uwdGo back to![]() ![]()
Fluorine binding site 3 out
of 3 in the Crystal Structure of Egfr Kinase Domain (L858R, T790M, V948R) in Complex with the Covalent Inhibitor Co-1686
![]() Mono view ![]() Stereo pair view
Reference:
S.Niessen,
M.M.Dix,
S.Barbas,
Z.E.Potter,
S.Lu,
O.Brodsky,
S.Planken,
D.Behenna,
C.Almaden,
K.S.Gajiwala,
K.Ryan,
R.Ferre,
M.R.Lazear,
M.M.Hayward,
J.C.Kath,
B.F.Cravatt.
Proteome-Wide Map of Targets of T790M-Egfr-Directed Covalent Inhibitors. Cell Chem Biol V. 24 1388 2017.
Page generated: Tue Jul 15 08:23:23 2025
ISSN: ESSN 2451-9456 PubMed: 28965727 DOI: 10.1016/J.CHEMBIOL.2017.08.017 |
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