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Fluorine in PDB 5v9l: Kras G12C in Bound to Quinazoline Based Switch II Pocket (Swiip) BinderProtein crystallography data
The structure of Kras G12C in Bound to Quinazoline Based Switch II Pocket (Swiip) Binder, PDB code: 5v9l
was solved by
K.Westover,
J.Lu,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 5v9l:
The structure of Kras G12C in Bound to Quinazoline Based Switch II Pocket (Swiip) Binder also contains other interesting chemical elements:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Kras G12C in Bound to Quinazoline Based Switch II Pocket (Swiip) Binder
(pdb code 5v9l). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 3 binding sites of Fluorine where determined in the Kras G12C in Bound to Quinazoline Based Switch II Pocket (Swiip) Binder, PDB code: 5v9l: Jump to Fluorine binding site number: 1; 2; 3; Fluorine binding site 1 out of 3 in 5v9lGo back to Fluorine Binding Sites List in 5v9l
Fluorine binding site 1 out
of 3 in the Kras G12C in Bound to Quinazoline Based Switch II Pocket (Swiip) Binder
Mono view Stereo pair view
Fluorine binding site 2 out of 3 in 5v9lGo back to Fluorine Binding Sites List in 5v9l
Fluorine binding site 2 out
of 3 in the Kras G12C in Bound to Quinazoline Based Switch II Pocket (Swiip) Binder
Mono view Stereo pair view
Fluorine binding site 3 out of 3 in 5v9lGo back to Fluorine Binding Sites List in 5v9l
Fluorine binding site 3 out
of 3 in the Kras G12C in Bound to Quinazoline Based Switch II Pocket (Swiip) Binder
Mono view Stereo pair view
Reference:
M.Zeng,
J.Lu,
L.Li,
F.Feru,
C.Quan,
T.W.Gero,
S.B.Ficarro,
Y.Xiong,
C.Ambrogio,
R.M.Paranal,
M.Catalano,
J.Shao,
K.K.Wong,
J.A.Marto,
E.S.Fischer,
P.A.Janne,
D.A.Scott,
K.D.Westover,
N.S.Gray.
Potent and Selective Covalent Quinazoline Inhibitors of Kras G12C. Cell Chem Biol V. 24 1005 2017.
Page generated: Sun Dec 13 12:40:22 2020
ISSN: ESSN 2451-9456 PubMed: 28781124 DOI: 10.1016/J.CHEMBIOL.2017.06.017 |
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