Atomistry » Fluorine » PDB 5vd4-5vsr » 5vew
Atomistry »
  Fluorine »
    PDB 5vd4-5vsr »
      5vew »

Fluorine in PDB 5vew: Structure of the Human Glp-1 Receptor Complex with Pf-06372222

Enzymatic activity of Structure of the Human Glp-1 Receptor Complex with Pf-06372222

All present enzymatic activity of Structure of the Human Glp-1 Receptor Complex with Pf-06372222:
3.2.1.17;

Protein crystallography data

The structure of Structure of the Human Glp-1 Receptor Complex with Pf-06372222, PDB code: 5vew was solved by G.Song, D.Yang, Y.Wang, C.D.Graaf, Q.Zhou, S.Jiang, K.Liu, X.Cai, A.Dai, G.Lin, D.Liu, F.Wu, Y.Wu, S.Zhao, L.Ye, G.W.Han, J.Lau, B.Wu, M.A.Hanson, Z.-J.Liu, M.-W.Wang, R.C.Stevens, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 30.00 / 2.70
Space group P 1
Cell size a, b, c (Å), α, β, γ (°) 64.770, 66.430, 83.440, 90.54, 90.18, 107.73
R / Rfree (%) 22.8 / 24.6

Fluorine Binding Sites:

The binding sites of Fluorine atom in the Structure of the Human Glp-1 Receptor Complex with Pf-06372222 (pdb code 5vew). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total 6 binding sites of Fluorine where determined in the Structure of the Human Glp-1 Receptor Complex with Pf-06372222, PDB code: 5vew:
Jump to Fluorine binding site number: 1; 2; 3; 4; 5; 6;

Fluorine binding site 1 out of 6 in 5vew

Go back to Fluorine Binding Sites List in 5vew
Fluorine binding site 1 out of 6 in the Structure of the Human Glp-1 Receptor Complex with Pf-06372222


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Structure of the Human Glp-1 Receptor Complex with Pf-06372222 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:F1201

b:94.3
occ:1.00
 F01 A:97Y1201 0.0 94.3 1.0
C21 A:97Y1201 1.4 92.8 1.0
F02 A:97Y1201 2.2 93.6 1.0
F03 A:97Y1201 2.3 92.9 1.0
C18 A:97Y1201 2.4 88.9 1.0
N09 A:97Y1201 2.9 89.2 1.0
CG1 A:VAL331 3.3 81.0 1.0
C22 A:97Y1201 3.7 85.2 1.0
CE1 A:PHE347 3.8 85.6 1.0
CD1 A:LEU335 3.8 88.1 1.0
CG1 A:VAL332 4.0 91.8 1.0
C23 A:97Y1201 4.1 88.6 1.0
CB A:VAL331 4.3 80.4 1.0
CG2 B:ILE286 4.5 89.0 1.0
O25 A:OLC1203 4.5 0.6 1.0
N07 A:97Y1201 4.5 85.9 1.0
CZ A:PHE347 4.6 85.3 1.0
N A:VAL332 4.6 85.1 1.0
CD1 A:PHE347 4.7 83.6 1.0
C A:VAL331 4.8 86.2 1.0
CA A:VAL332 4.8 87.4 1.0
CD1 B:LEU290 4.9 0.9 1.0

Fluorine binding site 2 out of 6 in 5vew

Go back to Fluorine Binding Sites List in 5vew
Fluorine binding site 2 out of 6 in the Structure of the Human Glp-1 Receptor Complex with Pf-06372222


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 2 of Structure of the Human Glp-1 Receptor Complex with Pf-06372222 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:F1201

b:93.6
occ:1.00
 F02 A:97Y1201 0.0 93.6 1.0
C21 A:97Y1201 1.4 92.8 1.0
F01 A:97Y1201 2.2 94.3 1.0
F03 A:97Y1201 2.2 92.9 1.0
C18 A:97Y1201 2.4 88.9 1.0
N09 A:97Y1201 3.2 89.2 1.0
C22 A:97Y1201 3.3 85.2 1.0
CD1 B:ILE286 3.3 88.4 1.0
CG2 B:ILE286 3.5 89.0 1.0
CG1 A:VAL332 3.9 91.8 1.0
CG1 B:ILE286 4.1 85.9 1.0
C23 A:97Y1201 4.3 88.6 1.0
CG2 A:ILE328 4.3 87.8 1.0
N07 A:97Y1201 4.3 85.9 1.0
CB B:ILE286 4.4 86.0 1.0
O25 A:OLC1203 4.9 0.6 1.0

Fluorine binding site 3 out of 6 in 5vew

Go back to Fluorine Binding Sites List in 5vew
Fluorine binding site 3 out of 6 in the Structure of the Human Glp-1 Receptor Complex with Pf-06372222


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 3 of Structure of the Human Glp-1 Receptor Complex with Pf-06372222 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:F1201

b:92.9
occ:1.00
 F03 A:97Y1201 0.0 92.9 1.0
C21 A:97Y1201 1.4 92.8 1.0
F02 A:97Y1201 2.2 93.6 1.0
F01 A:97Y1201 2.3 94.3 1.0
C18 A:97Y1201 2.4 88.9 1.0
C22 A:97Y1201 2.9 85.2 1.0
N09 A:97Y1201 3.6 89.2 1.0
CG1 A:VAL331 3.7 81.0 1.0
CD1 A:LEU354 3.9 78.9 1.0
CB A:VAL331 4.1 80.4 1.0
N07 A:97Y1201 4.1 85.9 1.0
CG1 A:ILE328 4.3 84.6 1.0
C23 A:97Y1201 4.4 88.6 1.0
CG2 A:ILE328 4.5 87.8 1.0
CA A:ILE328 4.5 82.4 1.0
CB A:ILE328 4.6 85.3 1.0
CG2 A:VAL331 4.7 78.7 1.0
CG1 A:VAL332 4.8 91.8 1.0
CE1 A:PHE347 4.9 85.6 1.0
O A:ILE328 4.9 90.6 1.0

Fluorine binding site 4 out of 6 in 5vew

Go back to Fluorine Binding Sites List in 5vew
Fluorine binding site 4 out of 6 in the Structure of the Human Glp-1 Receptor Complex with Pf-06372222


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 4 of Structure of the Human Glp-1 Receptor Complex with Pf-06372222 within 5.0Å range:
probe atom residue distance (Å) B Occ
B:F1202

b:89.6
occ:1.00
 F01 B:97Y1202 0.0 89.6 1.0
C21 B:97Y1202 1.4 89.3 1.0
F02 B:97Y1202 2.2 89.7 1.0
F03 B:97Y1202 2.2 90.7 1.0
C18 B:97Y1202 2.4 85.4 1.0
N09 B:97Y1202 2.9 84.9 1.0
CG1 B:VAL331 3.3 78.7 1.0
C22 B:97Y1202 3.7 81.6 1.0
CE1 B:PHE347 3.8 80.5 1.0
CD1 B:LEU335 3.8 78.3 1.0
CG1 B:VAL332 4.0 86.5 1.0
C23 B:97Y1202 4.1 83.6 1.0
O25 B:OLC1205 4.2 0.2 1.0
CB B:VAL331 4.2 78.0 1.0
N07 B:97Y1202 4.5 80.8 1.0
CZ B:PHE347 4.6 80.3 1.0
N B:VAL332 4.6 80.4 1.0
CD1 B:PHE347 4.7 78.8 1.0
C B:VAL331 4.7 82.5 1.0
C24 B:OLC1205 4.8 0.1 1.0
CA B:VAL332 4.9 82.2 1.0

Fluorine binding site 5 out of 6 in 5vew

Go back to Fluorine Binding Sites List in 5vew
Fluorine binding site 5 out of 6 in the Structure of the Human Glp-1 Receptor Complex with Pf-06372222


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 5 of Structure of the Human Glp-1 Receptor Complex with Pf-06372222 within 5.0Å range:
probe atom residue distance (Å) B Occ
B:F1202

b:89.7
occ:1.00
 F02 B:97Y1202 0.0 89.7 1.0
C21 B:97Y1202 1.4 89.3 1.0
F01 B:97Y1202 2.2 89.6 1.0
F03 B:97Y1202 2.2 90.7 1.0
C18 B:97Y1202 2.3 85.4 1.0
N09 B:97Y1202 3.2 84.9 1.0
C22 B:97Y1202 3.3 81.6 1.0
CG1 B:VAL332 3.9 86.5 1.0
C23 B:97Y1202 4.3 83.6 1.0
N07 B:97Y1202 4.3 80.8 1.0
CG2 B:ILE328 4.3 83.7 1.0
O23 B:OLC1203 4.4 0.4 1.0
C24 B:OLC1205 4.7 0.1 1.0
O25 B:OLC1205 4.7 0.2 1.0

Fluorine binding site 6 out of 6 in 5vew

Go back to Fluorine Binding Sites List in 5vew
Fluorine binding site 6 out of 6 in the Structure of the Human Glp-1 Receptor Complex with Pf-06372222


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 6 of Structure of the Human Glp-1 Receptor Complex with Pf-06372222 within 5.0Å range:
probe atom residue distance (Å) B Occ
B:F1202

b:90.7
occ:1.00
 F03 B:97Y1202 0.0 90.7 1.0
C21 B:97Y1202 1.4 89.3 1.0
F02 B:97Y1202 2.2 89.7 1.0
F01 B:97Y1202 2.2 89.6 1.0
C18 B:97Y1202 2.4 85.4 1.0
C22 B:97Y1202 2.9 81.6 1.0
N09 B:97Y1202 3.6 84.9 1.0
CG1 B:VAL331 3.7 78.7 1.0
CD1 B:LEU354 3.9 77.8 1.0
CB B:VAL331 4.1 78.0 1.0
N07 B:97Y1202 4.1 80.8 1.0
CG1 B:ILE328 4.3 80.5 1.0
C23 B:97Y1202 4.4 83.6 1.0
CG2 B:ILE328 4.5 83.7 1.0
CA B:ILE328 4.5 78.8 1.0
CB B:ILE328 4.7 81.4 1.0
CG2 B:VAL331 4.7 76.4 1.0
CG1 B:VAL332 4.8 86.5 1.0
CE1 B:PHE347 4.9 80.5 1.0
O B:ILE328 4.9 86.2 1.0

Reference:

G.Song, D.Yang, Y.Wang, C.De Graaf, Q.Zhou, S.Jiang, K.Liu, X.Cai, A.Dai, G.Lin, D.Liu, F.Wu, Y.Wu, S.Zhao, L.Ye, G.W.Han, J.Lau, B.Wu, M.A.Hanson, Z.J.Liu, M.W.Wang, R.C.Stevens. Human Glp-1 Receptor Transmembrane Domain Structure in Complex with Allosteric Modulators. Nature V. 546 312 2017.
ISSN: ISSN 0028-0836
PubMed: 28514449
DOI: 10.1038/NATURE22378
Page generated: Thu Aug 1 16:07:06 2024

Last articles

Zn in 9JYW
Zn in 9IR4
Zn in 9IR3
Zn in 9GMX
Zn in 9GMW
Zn in 9JEJ
Zn in 9ERF
Zn in 9ERE
Zn in 9EGV
Zn in 9EGW
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy