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Fluorine in PDB 5vqu: Crystal Structure of Hiv-1 Reverse Transcriptase (Y181C) Variant in Complex with N-(6-Cyano-3-(2-(2-(2,4-Dioxo-3,4-Dihydropyrimidin- 1(2H)-Yl)Ethoxy)Phenoxy)-4-Methylnaphthalen-1-Yl)-2-Fluoro-N- Methylacetamide (JLJ683), A Non-Nucleoside InhibitorEnzymatic activity of Crystal Structure of Hiv-1 Reverse Transcriptase (Y181C) Variant in Complex with N-(6-Cyano-3-(2-(2-(2,4-Dioxo-3,4-Dihydropyrimidin- 1(2H)-Yl)Ethoxy)Phenoxy)-4-Methylnaphthalen-1-Yl)-2-Fluoro-N- Methylacetamide (JLJ683), A Non-Nucleoside Inhibitor
All present enzymatic activity of Crystal Structure of Hiv-1 Reverse Transcriptase (Y181C) Variant in Complex with N-(6-Cyano-3-(2-(2-(2,4-Dioxo-3,4-Dihydropyrimidin- 1(2H)-Yl)Ethoxy)Phenoxy)-4-Methylnaphthalen-1-Yl)-2-Fluoro-N- Methylacetamide (JLJ683), A Non-Nucleoside Inhibitor:
2.7.7.49; 2.7.7.7; 3.1.26.13; Protein crystallography data
The structure of Crystal Structure of Hiv-1 Reverse Transcriptase (Y181C) Variant in Complex with N-(6-Cyano-3-(2-(2-(2,4-Dioxo-3,4-Dihydropyrimidin- 1(2H)-Yl)Ethoxy)Phenoxy)-4-Methylnaphthalen-1-Yl)-2-Fluoro-N- Methylacetamide (JLJ683), A Non-Nucleoside Inhibitor, PDB code: 5vqu
was solved by
Z.O.Petrova,
A.H.Chan,
K.S.Anderson,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structure of Hiv-1 Reverse Transcriptase (Y181C) Variant in Complex with N-(6-Cyano-3-(2-(2-(2,4-Dioxo-3,4-Dihydropyrimidin- 1(2H)-Yl)Ethoxy)Phenoxy)-4-Methylnaphthalen-1-Yl)-2-Fluoro-N- Methylacetamide (JLJ683), A Non-Nucleoside Inhibitor
(pdb code 5vqu). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Crystal Structure of Hiv-1 Reverse Transcriptase (Y181C) Variant in Complex with N-(6-Cyano-3-(2-(2-(2,4-Dioxo-3,4-Dihydropyrimidin- 1(2H)-Yl)Ethoxy)Phenoxy)-4-Methylnaphthalen-1-Yl)-2-Fluoro-N- Methylacetamide (JLJ683), A Non-Nucleoside Inhibitor, PDB code: 5vqu: Fluorine binding site 1 out of 1 in 5vquGo back to Fluorine Binding Sites List in 5vqu
Fluorine binding site 1 out
of 1 in the Crystal Structure of Hiv-1 Reverse Transcriptase (Y181C) Variant in Complex with N-(6-Cyano-3-(2-(2-(2,4-Dioxo-3,4-Dihydropyrimidin- 1(2H)-Yl)Ethoxy)Phenoxy)-4-Methylnaphthalen-1-Yl)-2-Fluoro-N- Methylacetamide (JLJ683), A Non-Nucleoside Inhibitor
Mono view Stereo pair view
Reference:
A.H.Chan,
W.G.Lee,
K.A.Spasov,
J.A.Cisneros,
S.N.Kudalkar,
Z.O.Petrova,
A.B.Buckingham,
K.S.Anderson,
W.L.Jorgensen.
Covalent Inhibitors For Eradication of Drug-Resistant Hiv-1 Reverse Transcriptase: From Design to Protein Crystallography. Proc. Natl. Acad. Sci. V. 114 9725 2017U.S.A..
Page generated: Sun Dec 13 12:40:59 2020
ISSN: ESSN 1091-6490 PubMed: 28827354 DOI: 10.1073/PNAS.1711463114 |
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