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Fluorine in PDB 5w58: Crystal Complex of Cyclooxygenase-2: (S)-Arn-2508 (A Dual Cox and Faah Inhibitor)Enzymatic activity of Crystal Complex of Cyclooxygenase-2: (S)-Arn-2508 (A Dual Cox and Faah Inhibitor)
All present enzymatic activity of Crystal Complex of Cyclooxygenase-2: (S)-Arn-2508 (A Dual Cox and Faah Inhibitor):
1.14.99.1; Protein crystallography data
The structure of Crystal Complex of Cyclooxygenase-2: (S)-Arn-2508 (A Dual Cox and Faah Inhibitor), PDB code: 5w58
was solved by
S.Xu,
M.C.Goodman,
S.Banerjee,
D.Piomelli,
L.J.Marnett,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 5w58:
The structure of Crystal Complex of Cyclooxygenase-2: (S)-Arn-2508 (A Dual Cox and Faah Inhibitor) also contains other interesting chemical elements:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Complex of Cyclooxygenase-2: (S)-Arn-2508 (A Dual Cox and Faah Inhibitor)
(pdb code 5w58). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Crystal Complex of Cyclooxygenase-2: (S)-Arn-2508 (A Dual Cox and Faah Inhibitor), PDB code: 5w58: Fluorine binding site 1 out of 1 in 5w58Go back to Fluorine Binding Sites List in 5w58
Fluorine binding site 1 out
of 1 in the Crystal Complex of Cyclooxygenase-2: (S)-Arn-2508 (A Dual Cox and Faah Inhibitor)
Mono view Stereo pair view
Reference:
M.C.Goodman,
S.Xu,
C.A.Rouzer,
S.Banerjee,
K.Ghebreselasie,
M.Migliore,
D.Piomelli,
L.J.Marnett.
Dual Cyclooxygenase-Fatty Acid Amide Hydrolase Inhibitor Exploits Novel Binding Interactions in the Cyclooxygenase Active Site. J. Biol. Chem. V. 293 3028 2018.
Page generated: Sun Dec 13 12:41:26 2020
ISSN: ESSN 1083-351X PubMed: 29326169 DOI: 10.1074/JBC.M117.802058 |
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