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Fluorine in PDB 5x8i: Crystal Structure of Human CLK1 in Complex with Compound 25Enzymatic activity of Crystal Structure of Human CLK1 in Complex with Compound 25
All present enzymatic activity of Crystal Structure of Human CLK1 in Complex with Compound 25:
2.7.12.1; Protein crystallography data
The structure of Crystal Structure of Human CLK1 in Complex with Compound 25, PDB code: 5x8i
was solved by
Q.Z.Sun,
G.F.Lin,
L.L.Li,
X.T.Jin,
L.Y.Huang,
G.Zhang,
Y.Q.Wei,
G.W.Lu,
S.Y.Yang,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structure of Human CLK1 in Complex with Compound 25
(pdb code 5x8i). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 2 binding sites of Fluorine where determined in the Crystal Structure of Human CLK1 in Complex with Compound 25, PDB code: 5x8i: Jump to Fluorine binding site number: 1; 2; Fluorine binding site 1 out of 2 in 5x8iGo back to Fluorine Binding Sites List in 5x8i
Fluorine binding site 1 out
of 2 in the Crystal Structure of Human CLK1 in Complex with Compound 25
Mono view Stereo pair view
Fluorine binding site 2 out of 2 in 5x8iGo back to Fluorine Binding Sites List in 5x8i
Fluorine binding site 2 out
of 2 in the Crystal Structure of Human CLK1 in Complex with Compound 25
Mono view Stereo pair view
Reference:
Q.Z.Sun,
G.F.Lin,
L.L.Li,
X.T.Jin,
L.Y.Huang,
G.Zhang,
W.Yang,
K.Chen,
R.Xiang,
C.Chen,
Y.Q.Wei,
G.W.Lu,
S.Y.Yang.
Discovery of Potent and Selective Inhibitors of CDC2-Like Kinase 1 (CLK1) As A New Class of Autophagy Inducers J. Med. Chem. V. 60 6337 2017.
Page generated: Sun Dec 13 12:42:21 2020
ISSN: ISSN 1520-4804 PubMed: 28692292 DOI: 10.1021/ACS.JMEDCHEM.7B00665 |
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