Fluorine in PDB 5z1h: Crystal Structure of the Bacterial Ribosomal Decoding Site in Complex with 6'-Fluoro Sisomicin

The structure of Crystal Structure of the Bacterial Ribosomal Decoding Site in Complex with 6'-Fluoro Sisomicin, PDB code: 5z1h was solved by H.Kanazawa, S.Hanessian, J.Kondo, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	42.80 / 2.40
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	42.905, 31.665, 46.696, 90.00, 94.82, 90.00
R / Rfree (%)	21.3 / 26.3

The binding sites of Fluorine atom in the Crystal Structure of the Bacterial Ribosomal Decoding Site in Complex with 6'-Fluoro Sisomicin (pdb code 5z1h). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Crystal Structure of the Bacterial Ribosomal Decoding Site in Complex with 6'-Fluoro Sisomicin, PDB code: 5z1h:

Fluorine binding site 1 out of 1 in the Crystal Structure of the Bacterial Ribosomal Decoding Site in Complex with 6'-Fluoro Sisomicin


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Crystal Structure of the Bacterial Ribosomal Decoding Site in Complex with 6'-Fluoro Sisomicin within 5.0Å range: probe atom residue distance (Å) B Occ A:F301 b:41.5 occ:1.00 F61 A:FSJ301 0.0 41.5 1.0 C61 A:FSJ301 1.4 26.8 1.0 C51 A:FSJ301 2.4 24.3 1.0 O51 A:FSJ301 2.7 23.4 1.0 N6 A:A8 3.0 26.2 1.0 O A:HOH407 3.1 31.6 1.0 N1 A:A8 3.1 20.2 1.0 C6 A:A8 3.5 23.4 1.0 O2 A:C9 3.6 26.9 1.0 C41 A:FSJ301 3.7 22.9 1.0 O B:HOH135 3.8 25.2 1.0 N7 B:G42 3.9 21.3 1.0 N2 B:G39 4.0 21.5 1.0 C11 A:FSJ301 4.1 18.0 1.0 C8 B:G42 4.1 14.9 1.0 N1 B:G39 4.1 25.0 1.0 C2 B:G39 4.2 23.9 1.0 C2 A:C9 4.2 25.8 1.0 C2 A:A8 4.2 21.6 1.0 N3 A:C9 4.3 27.8 1.0 O11 A:FSJ301 4.4 24.4 1.0 N32 A:FSJ301 4.5 25.9 1.0 C5 B:G42 4.5 17.6 1.0 OP2 B:A41 4.5 25.3 1.0 N9 B:G42 4.8 20.6 1.0 C6 B:G39 4.9 23.0 1.0 C5 A:A8 4.9 23.4 1.0 N3 B:G39 4.9 23.8 1.0 C42 A:FSJ301 5.0 24.2 1.0

H.Kanazawa, O.M.Saavedra, J.P.Maianti, S.A.Young, L.Izquierdo, T.K.Smith, S.Hanessian, J.Kondo. Structure-Based Design of A Eukaryote-Selective Antiprotozoal Fluorinated Aminoglycoside. Chemmedchem V. 13 1541 2018.
ISSN: ESSN 1860-7187
PubMed: 29766661
DOI: 10.1002/CMDC.201800166