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Fluorine in PDB 5zhp: M3 Muscarinic Acetylcholine Receptor in Complex with A Selective AntagonistEnzymatic activity of M3 Muscarinic Acetylcholine Receptor in Complex with A Selective Antagonist
All present enzymatic activity of M3 Muscarinic Acetylcholine Receptor in Complex with A Selective Antagonist:
3.2.1.17; Protein crystallography data
The structure of M3 Muscarinic Acetylcholine Receptor in Complex with A Selective Antagonist, PDB code: 5zhp
was solved by
H.Liu,
J.Hofmann,
I.Fish,
B.Schaake,
K.Eitel,
A.Bartuschat,
J.Kaindl,
H.Rampp,
A.Banerjee,
H.Hubner,
M.J.Clark,
S.G.Vincent,
J.Fisher,
M.Heinrich,
K.Hirata,
X.Liu,
R.K.Sunahara,
B.K.Shoichet,
B.K.Kobilka,
P.Gmeiner,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the M3 Muscarinic Acetylcholine Receptor in Complex with A Selective Antagonist
(pdb code 5zhp). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 2 binding sites of Fluorine where determined in the M3 Muscarinic Acetylcholine Receptor in Complex with A Selective Antagonist, PDB code: 5zhp: Jump to Fluorine binding site number: 1; 2; Fluorine binding site 1 out of 2 in 5zhpGo back to Fluorine Binding Sites List in 5zhp
Fluorine binding site 1 out
of 2 in the M3 Muscarinic Acetylcholine Receptor in Complex with A Selective Antagonist
Mono view Stereo pair view
Fluorine binding site 2 out of 2 in 5zhpGo back to Fluorine Binding Sites List in 5zhp
Fluorine binding site 2 out
of 2 in the M3 Muscarinic Acetylcholine Receptor in Complex with A Selective Antagonist
Mono view Stereo pair view
Reference:
H.Liu,
J.Hofmann,
I.Fish,
B.Schaake,
K.Eitel,
A.Bartuschat,
J.Kaindl,
H.Rampp,
A.Banerjee,
H.Hubner,
M.J.Clark,
S.G.Vincent,
J.T.Fisher,
M.R.Heinrich,
K.Hirata,
X.Liu,
R.K.Sunahara,
B.K.Shoichet,
B.K.Kobilka,
P.Gmeiner.
Structure-Guided Development of Selective M3 Muscarinic Acetylcholine Receptor Antagonists Proc. Natl. Acad. Sci. V. 115 12046 2018U.S.A..
Page generated: Sun Dec 13 12:43:43 2020
ISSN: ESSN 1091-6490 PubMed: 30404914 DOI: 10.1073/PNAS.1813988115 |
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