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Fluorine in PDB 5zqr: Tankyrase-2 in Complex with Compound 40CEnzymatic activity of Tankyrase-2 in Complex with Compound 40C
All present enzymatic activity of Tankyrase-2 in Complex with Compound 40C:
2.4.2.30; Protein crystallography data
The structure of Tankyrase-2 in Complex with Compound 40C, PDB code: 5zqr
was solved by
H.Niwa,
F.Shirai,
S.Sato,
N.Yoshimoto,
T.Tsumura,
M.Okue,
M.Shirouzu,
H.Seimiya,
T.Umehara,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 5zqr:
The structure of Tankyrase-2 in Complex with Compound 40C also contains other interesting chemical elements:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Tankyrase-2 in Complex with Compound 40C
(pdb code 5zqr). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 2 binding sites of Fluorine where determined in the Tankyrase-2 in Complex with Compound 40C, PDB code: 5zqr: Jump to Fluorine binding site number: 1; 2; Fluorine binding site 1 out of 2 in 5zqrGo back to Fluorine Binding Sites List in 5zqr
Fluorine binding site 1 out
of 2 in the Tankyrase-2 in Complex with Compound 40C
Mono view Stereo pair view
Fluorine binding site 2 out of 2 in 5zqrGo back to Fluorine Binding Sites List in 5zqr
Fluorine binding site 2 out
of 2 in the Tankyrase-2 in Complex with Compound 40C
Mono view Stereo pair view
Reference:
F.Shirai,
T.Tsumura,
Y.Yashiroda,
H.Yuki,
H.Niwa,
S.Sato,
T.Chikada,
Y.Koda,
K.Washizuka,
N.Yoshimoto,
M.Abe,
T.Onuki,
Y.Mazaki,
C.Hirama,
T.Fukami,
H.Watanabe,
T.Honma,
T.Umehara,
M.Shirouzu,
M.Okue,
Y.Kano,
T.Watanabe,
K.Kitamura,
E.Shitara,
Y.Muramatsu,
H.Yoshida,
A.Mizutani,
H.Seimiya,
M.Yoshida,
H.Koyama.
Discovery of Novel Spiroindoline Derivatives As Selective Tankyrase Inhibitors. J. Med. Chem. V. 62 3407 2019.
Page generated: Sun Dec 13 12:43:53 2020
ISSN: ISSN 1520-4804 PubMed: 30883102 DOI: 10.1021/ACS.JMEDCHEM.8B01888 |
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