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Fluorine in PDB 6a3n: Crystal Structure of the PDE9 Catalytic Domain in Complex with Inhibitor 2Enzymatic activity of Crystal Structure of the PDE9 Catalytic Domain in Complex with Inhibitor 2
All present enzymatic activity of Crystal Structure of the PDE9 Catalytic Domain in Complex with Inhibitor 2:
3.1.4.35; Protein crystallography data
The structure of Crystal Structure of the PDE9 Catalytic Domain in Complex with Inhibitor 2, PDB code: 6a3n
was solved by
Y.N.Wu,
Q.Zhou,
Y.P.Chen,
H.B.Luo,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 6a3n:
The structure of Crystal Structure of the PDE9 Catalytic Domain in Complex with Inhibitor 2 also contains other interesting chemical elements:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structure of the PDE9 Catalytic Domain in Complex with Inhibitor 2
(pdb code 6a3n). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 2 binding sites of Fluorine where determined in the Crystal Structure of the PDE9 Catalytic Domain in Complex with Inhibitor 2, PDB code: 6a3n: Jump to Fluorine binding site number: 1; 2; Fluorine binding site 1 out of 2 in 6a3nGo back to Fluorine Binding Sites List in 6a3n
Fluorine binding site 1 out
of 2 in the Crystal Structure of the PDE9 Catalytic Domain in Complex with Inhibitor 2
Mono view Stereo pair view
Fluorine binding site 2 out of 2 in 6a3nGo back to Fluorine Binding Sites List in 6a3n
Fluorine binding site 2 out
of 2 in the Crystal Structure of the PDE9 Catalytic Domain in Complex with Inhibitor 2
Mono view Stereo pair view
Reference:
Y.Wu,
Q.Zhou,
T.Zhang,
Z.Li,
Y.P.Chen,
P.Zhang,
Y.F.Yu,
H.Geng,
Y.J.Tian,
C.Zhang,
Y.Wang,
J.W.Chen,
Y.Chen,
H.B.Luo.
Discovery of Potent, Selective, and Orally Bioavailable Inhibitors Against Phosphodiesterase-9, A Novel Target For the Treatment of Vascular Dementia. J. Med. Chem. V. 62 4218 2019.
Page generated: Sun Dec 13 12:44:06 2020
ISSN: ISSN 1520-4804 PubMed: 30916555 DOI: 10.1021/ACS.JMEDCHEM.8B01041 |
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