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Fluorine in PDB 6acb: Crystal Structure of PDE5 in Complex with Inhibitor LW1805Enzymatic activity of Crystal Structure of PDE5 in Complex with Inhibitor LW1805
All present enzymatic activity of Crystal Structure of PDE5 in Complex with Inhibitor LW1805:
3.1.4.35; Protein crystallography data
The structure of Crystal Structure of PDE5 in Complex with Inhibitor LW1805, PDB code: 6acb
was solved by
D.Wu,
Y.D.Huang,
Y.Y.Huang,
H.B.Luo,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 6acb:
The structure of Crystal Structure of PDE5 in Complex with Inhibitor LW1805 also contains other interesting chemical elements:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structure of PDE5 in Complex with Inhibitor LW1805
(pdb code 6acb). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Crystal Structure of PDE5 in Complex with Inhibitor LW1805, PDB code: 6acb: Fluorine binding site 1 out of 1 in 6acbGo back to Fluorine Binding Sites List in 6acb
Fluorine binding site 1 out
of 1 in the Crystal Structure of PDE5 in Complex with Inhibitor LW1805
Mono view Stereo pair view
Reference:
D.Wu,
Y.Huang,
Y.Chen,
Y.Y.Huang,
H.Geng,
T.Zhang,
C.Zhang,
Z.Li,
L.Guo,
J.Chen,
H.B.Luo.
Optimization of Chromeno[2,3- C]Pyrrol-9(2 H)-Ones As Highly Potent, Selective, and Orally Bioavailable PDE5 Inhibitors: Structure-Activity Relationship, X-Ray Crystal Structure, and Pharmacodynamic Effect on Pulmonary Arterial Hypertension. J. Med. Chem. V. 61 8468 2018.
Page generated: Sun Dec 13 12:44:10 2020
ISSN: ISSN 1520-4804 PubMed: 30148362 DOI: 10.1021/ACS.JMEDCHEM.8B01209 |
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