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Fluorine in PDB 6ary: Crystal Structure of An Insecticide-Resistant Acetylcholinesterase Mutant From the Malaria Vector Anopheles Gambiae in Complex with A Difluoromethyl Ketone Inhibitor
Enzymatic activity of Crystal Structure of An Insecticide-Resistant Acetylcholinesterase Mutant From the Malaria Vector Anopheles Gambiae in Complex with A Difluoromethyl Ketone Inhibitor
All present enzymatic activity of Crystal Structure of An Insecticide-Resistant Acetylcholinesterase Mutant From the Malaria Vector Anopheles Gambiae in Complex with A Difluoromethyl Ketone Inhibitor:
3.1.1.7;
3.1.1.7;
Protein crystallography data
The structure of Crystal Structure of An Insecticide-Resistant Acetylcholinesterase Mutant From the Malaria Vector Anopheles Gambiae in Complex with A Difluoromethyl Ketone Inhibitor, PDB code: 6ary
was solved by
J.Cheung,
A.Mahmood,
R.Kalathur,
L.Lixuan,
P.R.Carlier,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 49.30 / 2.26 |
| Space group | P 61 |
| Cell size a, b, c (Å), α, β, γ (°) | 150.333, 150.333, 226.478, 90.00, 90.00, 120.00 |
| R / Rfree (%) | 16.2 / 18.6 |
Other elements in 6ary:
The structure of Crystal Structure of An Insecticide-Resistant Acetylcholinesterase Mutant From the Malaria Vector Anopheles Gambiae in Complex with A Difluoromethyl Ketone Inhibitor also contains other interesting chemical elements:
| Chlorine | (Cl) | 1 atom |
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structure of An Insecticide-Resistant Acetylcholinesterase Mutant From the Malaria Vector Anopheles Gambiae in Complex with A Difluoromethyl Ketone Inhibitor
(pdb code 6ary). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 4 binding sites of Fluorine where determined in the Crystal Structure of An Insecticide-Resistant Acetylcholinesterase Mutant From the Malaria Vector Anopheles Gambiae in Complex with A Difluoromethyl Ketone Inhibitor, PDB code: 6ary:
Jump to Fluorine binding site number: 1; 2; 3; 4;
In total 4 binding sites of Fluorine where determined in the Crystal Structure of An Insecticide-Resistant Acetylcholinesterase Mutant From the Malaria Vector Anopheles Gambiae in Complex with A Difluoromethyl Ketone Inhibitor, PDB code: 6ary:
Jump to Fluorine binding site number: 1; 2; 3; 4;
Fluorine binding site 1 out of 4 in 6ary
Go back to
Fluorine Binding Sites List in 6ary
Fluorine binding site 1 out
of 4 in the Crystal Structure of An Insecticide-Resistant Acetylcholinesterase Mutant From the Malaria Vector Anopheles Gambiae in Complex with A Difluoromethyl Ketone Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 1 of Crystal Structure of An Insecticide-Resistant Acetylcholinesterase Mutant From the Malaria Vector Anopheles Gambiae in Complex with A Difluoromethyl Ketone Inhibitor within 5.0Å range:
|
Fluorine binding site 2 out of 4 in 6ary
Go back to
Fluorine Binding Sites List in 6ary
Fluorine binding site 2 out
of 4 in the Crystal Structure of An Insecticide-Resistant Acetylcholinesterase Mutant From the Malaria Vector Anopheles Gambiae in Complex with A Difluoromethyl Ketone Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 2 of Crystal Structure of An Insecticide-Resistant Acetylcholinesterase Mutant From the Malaria Vector Anopheles Gambiae in Complex with A Difluoromethyl Ketone Inhibitor within 5.0Å range:
|
Fluorine binding site 3 out of 4 in 6ary
Go back to
Fluorine Binding Sites List in 6ary
Fluorine binding site 3 out
of 4 in the Crystal Structure of An Insecticide-Resistant Acetylcholinesterase Mutant From the Malaria Vector Anopheles Gambiae in Complex with A Difluoromethyl Ketone Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 3 of Crystal Structure of An Insecticide-Resistant Acetylcholinesterase Mutant From the Malaria Vector Anopheles Gambiae in Complex with A Difluoromethyl Ketone Inhibitor within 5.0Å range:
|
Fluorine binding site 4 out of 4 in 6ary
Go back to
Fluorine Binding Sites List in 6ary
Fluorine binding site 4 out
of 4 in the Crystal Structure of An Insecticide-Resistant Acetylcholinesterase Mutant From the Malaria Vector Anopheles Gambiae in Complex with A Difluoromethyl Ketone Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 4 of Crystal Structure of An Insecticide-Resistant Acetylcholinesterase Mutant From the Malaria Vector Anopheles Gambiae in Complex with A Difluoromethyl Ketone Inhibitor within 5.0Å range:
|
Reference:
J.Cheung,
A.Mahmood,
R.Kalathur,
L.Liu,
P.R.Carlier.
Structure of the G119S Mutant Acetylcholinesterase of the Malaria Vector Anopheles Gambiae Reveals Basis of Insecticide Resistance. Structure V. 26 130 2018.
ISSN: ISSN 1878-4186
PubMed: 29276037
DOI: 10.1016/J.STR.2017.11.021
Page generated: Tue Jul 15 09:45:20 2025
ISSN: ISSN 1878-4186
PubMed: 29276037
DOI: 10.1016/J.STR.2017.11.021
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