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Fluorine in PDB 6ba2: Crystal Structure of Myst Acetyltransferase Domain in Complex with Inhibitor
Enzymatic activity of Crystal Structure of Myst Acetyltransferase Domain in Complex with Inhibitor
All present enzymatic activity of Crystal Structure of Myst Acetyltransferase Domain in Complex with Inhibitor:
2.3.1.48;
2.3.1.48;
Protein crystallography data
The structure of Crystal Structure of Myst Acetyltransferase Domain in Complex with Inhibitor, PDB code: 6ba2
was solved by
S.J.Hermans,
M.C.Chung,
T.S.Peat,
J.B.Baell,
T.Thomas,
M.W.Parker,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 43.19 / 1.85 |
| Space group | P 21 21 21 |
| Cell size a, b, c (Å), α, β, γ (°) | 46.231, 56.916, 120.999, 90.00, 90.00, 90.00 |
| R / Rfree (%) | 19.4 / 22.8 |
Other elements in 6ba2:
The structure of Crystal Structure of Myst Acetyltransferase Domain in Complex with Inhibitor also contains other interesting chemical elements:
| Zinc | (Zn) | 1 atom |
| Chlorine | (Cl) | 1 atom |
| Sodium | (Na) | 1 atom |
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structure of Myst Acetyltransferase Domain in Complex with Inhibitor
(pdb code 6ba2). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Crystal Structure of Myst Acetyltransferase Domain in Complex with Inhibitor, PDB code: 6ba2:
In total only one binding site of Fluorine was determined in the Crystal Structure of Myst Acetyltransferase Domain in Complex with Inhibitor, PDB code: 6ba2:
Fluorine binding site 1 out of 1 in 6ba2
Go back to
Fluorine Binding Sites List in 6ba2
Fluorine binding site 1 out
of 1 in the Crystal Structure of Myst Acetyltransferase Domain in Complex with Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 1 of Crystal Structure of Myst Acetyltransferase Domain in Complex with Inhibitor within 5.0Å range:
|
Reference:
J.B.Baell,
D.J.Leaver,
S.J.Hermans,
G.L.Kelly,
M.S.Brennan,
N.L.Downer,
N.Nguyen,
J.Wichmann,
H.M.Mcrae,
Y.Yang,
B.Cleary,
H.R.Lagiakos,
S.Mieruszynski,
G.Pacini,
H.K.Vanyai,
M.I.Bergamasco,
R.E.May,
B.K.Davey,
K.J.Morgan,
A.J.Sealey,
B.Wang,
N.Zamudio,
S.Wilcox,
A.L.Garnham,
B.N.Sheikh,
B.J.Aubrey,
K.Doggett,
M.C.Chung,
M.De Silva,
J.Bentley,
P.Pilling,
M.Hattarki,
O.Dolezal,
M.L.Dennis,
H.Falk,
B.Ren,
S.A.Charman,
K.L.White,
J.Rautela,
A.Newbold,
E.D.Hawkins,
R.W.Johnstone,
N.D.Huntington,
T.S.Peat,
J.K.Heath,
A.Strasser,
M.W.Parker,
G.K.Smyth,
I.P.Street,
B.J.Monahan,
A.K.Voss,
T.Thomas.
Inhibitors of Histone Acetyltransferases KAT6A/B Induce Senescence and Arrest Tumour Growth. Nature V. 560 253 2018.
ISSN: ESSN 1476-4687
PubMed: 30069049
DOI: 10.1038/S41586-018-0387-5
Page generated: Thu Aug 1 18:02:03 2024
ISSN: ESSN 1476-4687
PubMed: 30069049
DOI: 10.1038/S41586-018-0387-5
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