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Fluorine in PDB 6bns: Structure of Human Pregnane X Receptor Ligand Binding Domain Bound Tethered with Src Co-Activator Peptide and Compound 25A Aka Bicyclic Hexafluoroisopropyl 2 Alcohol Sulfonamides

Enzymatic activity of Structure of Human Pregnane X Receptor Ligand Binding Domain Bound Tethered with Src Co-Activator Peptide and Compound 25A Aka Bicyclic Hexafluoroisopropyl 2 Alcohol Sulfonamides

All present enzymatic activity of Structure of Human Pregnane X Receptor Ligand Binding Domain Bound Tethered with Src Co-Activator Peptide and Compound 25A Aka Bicyclic Hexafluoroisopropyl 2 Alcohol Sulfonamides:
2.3.1.48;

Protein crystallography data

The structure of Structure of Human Pregnane X Receptor Ligand Binding Domain Bound Tethered with Src Co-Activator Peptide and Compound 25A Aka Bicyclic Hexafluoroisopropyl 2 Alcohol Sulfonamides, PDB code: 6bns was solved by T.G.Dhar, H.Gong, D.S.Weinstein, Z.Lu, J.J.W.Duan, S.Stachura, L.Haque, A.Karmakar, H.Hemagiri, D.K.Raut, A.K.Gupta, J.A.Khan, J.S.Sack, D.M.Camac, A.A.Pudzianowski, D.R.Wu, M.Yarde, D.R.Shen, V.Borowski, J.H.Xie, H.Sun, C.D.Arienzo, M.Dabros, M.A.Galella, F.Wang, C.A.Weigelt, Q.Zhao, W.Foster, J.E.Somerville, L.M.Salter-Cid, J.C.Barrish, P.H.Carter, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 45.54 / 2.56
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 84.370, 89.234, 105.902, 90.00, 90.00, 90.00
R / Rfree (%) 20.3 / 24.6

Fluorine Binding Sites:

Pages:

>>> Page 1 <<< Page 2, Binding sites: 11 - 13;

Binding sites:

The binding sites of Fluorine atom in the Structure of Human Pregnane X Receptor Ligand Binding Domain Bound Tethered with Src Co-Activator Peptide and Compound 25A Aka Bicyclic Hexafluoroisopropyl 2 Alcohol Sulfonamides (pdb code 6bns). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total 13 binding sites of Fluorine where determined in the Structure of Human Pregnane X Receptor Ligand Binding Domain Bound Tethered with Src Co-Activator Peptide and Compound 25A Aka Bicyclic Hexafluoroisopropyl 2 Alcohol Sulfonamides, PDB code: 6bns:
Jump to Fluorine binding site number: 1; 2; 3; 4; 5; 6; 7; 8; 9; 10;

Fluorine binding site 1 out of 13 in 6bns

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Fluorine binding site 1 out of 13 in the Structure of Human Pregnane X Receptor Ligand Binding Domain Bound Tethered with Src Co-Activator Peptide and Compound 25A Aka Bicyclic Hexafluoroisopropyl 2 Alcohol Sulfonamides


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Structure of Human Pregnane X Receptor Ligand Binding Domain Bound Tethered with Src Co-Activator Peptide and Compound 25A Aka Bicyclic Hexafluoroisopropyl 2 Alcohol Sulfonamides within 5.0Å range:
probe atom residue distance (Å) B Occ
A:F501

b:81.5
occ:1.00
 F6 A:XGH501 0.0 81.5 1.0
C22 A:XGH501 1.3 79.3 1.0
F4 A:XGH501 2.1 77.9 1.0
F5 A:XGH501 2.1 79.8 1.0
C20 A:XGH501 2.4 77.6 1.0
O4 A:XGH501 2.7 77.0 1.0
F3 A:XGH501 2.7 74.2 1.0
C21 A:XGH501 2.9 74.8 1.0
CE1 A:PHE420 3.2 44.6 1.0
F1 A:XGH501 3.3 75.0 1.0
CE A:MET425 3.3 46.6 1.0
CZ A:PHE420 3.4 44.2 1.0
CD1 A:LEU411 3.6 47.2 1.0
C1 A:XGH501 3.8 77.7 1.0
F2 A:XGH501 4.2 72.7 1.0
OG A:SER247 4.3 52.8 1.0
O A:HOH620 4.4 61.2 1.0
C2 A:XGH501 4.4 78.0 1.0
CG A:LEU411 4.5 46.2 1.0
CD1 A:PHE420 4.5 44.4 1.0
NE2 A:HIS407 4.7 50.0 1.0
C A:XGH501 4.7 77.5 1.0
CE2 A:PHE420 4.7 46.1 1.0
SD A:MET425 4.8 50.7 1.0

Fluorine binding site 2 out of 13 in 6bns

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Fluorine binding site 2 out of 13 in the Structure of Human Pregnane X Receptor Ligand Binding Domain Bound Tethered with Src Co-Activator Peptide and Compound 25A Aka Bicyclic Hexafluoroisopropyl 2 Alcohol Sulfonamides


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 2 of Structure of Human Pregnane X Receptor Ligand Binding Domain Bound Tethered with Src Co-Activator Peptide and Compound 25A Aka Bicyclic Hexafluoroisopropyl 2 Alcohol Sulfonamides within 5.0Å range:
probe atom residue distance (Å) B Occ
A:F501

b:77.9
occ:1.00
 F4 A:XGH501 0.0 77.9 1.0
C22 A:XGH501 1.3 79.3 1.0
F6 A:XGH501 2.1 81.5 1.0
F5 A:XGH501 2.1 79.8 1.0
C20 A:XGH501 2.4 77.6 1.0
O4 A:XGH501 2.7 77.0 1.0
OG A:SER247 2.9 52.8 1.0
C1 A:XGH501 3.0 77.7 1.0
O A:HOH620 3.4 61.2 1.0
O A:MET243 3.5 44.1 1.0
C A:XGH501 3.6 77.5 1.0
CB A:MET243 3.6 41.4 1.0
C2 A:XGH501 3.7 78.0 1.0
C A:MET243 3.8 43.0 1.0
C21 A:XGH501 3.8 74.8 1.0
CB A:SER247 4.1 39.6 1.0
F3 A:XGH501 4.2 74.2 1.0
F1 A:XGH501 4.2 75.0 1.0
CA A:MET243 4.2 38.5 1.0
N A:ALA244 4.3 37.6 1.0
CE A:MET425 4.6 46.6 1.0
C5 A:XGH501 4.6 79.2 1.0
CG A:MET243 4.7 46.2 1.0
CE1 A:PHE420 4.7 44.6 1.0
C3 A:XGH501 4.7 78.8 1.0
CA A:ALA244 4.8 37.2 1.0
F2 A:XGH501 4.8 72.7 1.0

Fluorine binding site 3 out of 13 in 6bns

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Fluorine binding site 3 out of 13 in the Structure of Human Pregnane X Receptor Ligand Binding Domain Bound Tethered with Src Co-Activator Peptide and Compound 25A Aka Bicyclic Hexafluoroisopropyl 2 Alcohol Sulfonamides


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 3 of Structure of Human Pregnane X Receptor Ligand Binding Domain Bound Tethered with Src Co-Activator Peptide and Compound 25A Aka Bicyclic Hexafluoroisopropyl 2 Alcohol Sulfonamides within 5.0Å range:
probe atom residue distance (Å) B Occ
A:F501

b:79.8
occ:1.00
 F5 A:XGH501 0.0 79.8 1.0
C22 A:XGH501 1.3 79.3 1.0
F6 A:XGH501 2.1 81.5 1.0
F4 A:XGH501 2.1 77.9 1.0
C20 A:XGH501 2.4 77.6 1.0
F1 A:XGH501 2.8 75.0 1.0
C1 A:XGH501 2.9 77.7 1.0
C2 A:XGH501 3.0 78.0 1.0
C21 A:XGH501 3.0 74.8 1.0
CE1 A:PHE420 3.2 44.6 1.0
CB A:MET243 3.4 41.4 1.0
O4 A:XGH501 3.5 77.0 1.0
F3 A:XGH501 3.7 74.2 1.0
CD2 A:LEU240 3.7 49.6 1.0
CZ A:PHE420 3.7 44.2 1.0
C3 A:XGH501 4.1 78.8 1.0
C A:XGH501 4.1 77.5 1.0
F2 A:XGH501 4.2 72.7 1.0
CD1 A:PHE420 4.2 44.4 1.0
C A:MET243 4.3 43.0 1.0
O A:LEU240 4.4 44.2 1.0
N A:ALA244 4.4 37.6 1.0
CG A:MET243 4.4 46.2 1.0
CA A:MET243 4.5 38.5 1.0
O A:MET243 4.6 44.1 1.0
CA A:LEU240 4.8 43.7 1.0
S A:XGH501 4.8 75.4 1.0
CG A:LEU240 4.9 49.5 1.0
CE A:MET425 4.9 46.6 1.0
OG A:SER247 5.0 52.8 1.0
CB A:LEU240 5.0 44.3 1.0
CA A:ALA244 5.0 37.2 1.0

Fluorine binding site 4 out of 13 in 6bns

Go back to Fluorine Binding Sites List in 6bns
Fluorine binding site 4 out of 13 in the Structure of Human Pregnane X Receptor Ligand Binding Domain Bound Tethered with Src Co-Activator Peptide and Compound 25A Aka Bicyclic Hexafluoroisopropyl 2 Alcohol Sulfonamides


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 4 of Structure of Human Pregnane X Receptor Ligand Binding Domain Bound Tethered with Src Co-Activator Peptide and Compound 25A Aka Bicyclic Hexafluoroisopropyl 2 Alcohol Sulfonamides within 5.0Å range:
probe atom residue distance (Å) B Occ
A:F501

b:74.2
occ:1.00
 F3 A:XGH501 0.0 74.2 1.0
C21 A:XGH501 1.3 74.8 1.0
F1 A:XGH501 2.1 75.0 1.0
F2 A:XGH501 2.1 72.7 1.0
C20 A:XGH501 2.4 77.6 1.0
O4 A:XGH501 2.6 77.0 1.0
F6 A:XGH501 2.7 81.5 1.0
C22 A:XGH501 3.0 79.3 1.0
CD1 A:LEU411 3.2 47.2 1.0
NE2 A:HIS407 3.3 50.0 1.0
CB A:LEU411 3.3 42.4 1.0
CG A:LEU411 3.4 46.2 1.0
F5 A:XGH501 3.7 79.8 1.0
C1 A:XGH501 3.7 77.7 1.0
CA A:LEU411 3.7 43.2 1.0
CZ A:PHE420 3.8 44.2 1.0
CE1 A:HIS407 3.9 49.8 1.0
CD2 A:HIS407 4.2 50.4 1.0
F4 A:XGH501 4.2 77.9 1.0
N A:LEU411 4.3 44.0 1.0
C2 A:XGH501 4.3 78.0 1.0
CE1 A:PHE420 4.5 44.6 1.0
C A:XGH501 4.7 77.5 1.0
CE2 A:PHE420 4.8 46.1 1.0
CD1 A:ILE414 4.8 68.3 1.0
ND1 A:HIS407 4.9 50.7 1.0
CD2 A:LEU411 4.9 43.4 1.0
O A:HIS407 5.0 46.4 1.0

Fluorine binding site 5 out of 13 in 6bns

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Fluorine binding site 5 out of 13 in the Structure of Human Pregnane X Receptor Ligand Binding Domain Bound Tethered with Src Co-Activator Peptide and Compound 25A Aka Bicyclic Hexafluoroisopropyl 2 Alcohol Sulfonamides


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 5 of Structure of Human Pregnane X Receptor Ligand Binding Domain Bound Tethered with Src Co-Activator Peptide and Compound 25A Aka Bicyclic Hexafluoroisopropyl 2 Alcohol Sulfonamides within 5.0Å range:
probe atom residue distance (Å) B Occ
A:F501

b:72.7
occ:1.00
 F2 A:XGH501 0.0 72.7 1.0
C21 A:XGH501 1.3 74.8 1.0
F3 A:XGH501 2.1 74.2 1.0
F1 A:XGH501 2.1 75.0 1.0
C20 A:XGH501 2.4 77.6 1.0
C1 A:XGH501 2.8 77.7 1.0
O4 A:XGH501 2.9 77.0 1.0
C2 A:XGH501 3.3 78.0 1.0
NE2 A:HIS407 3.4 50.0 1.0
C A:XGH501 3.6 77.5 1.0
CD2 A:HIS407 3.6 50.4 1.0
C22 A:XGH501 3.8 79.3 1.0
F6 A:XGH501 4.2 81.5 1.0
F5 A:XGH501 4.2 79.8 1.0
C3 A:XGH501 4.4 78.8 1.0
CE1 A:HIS407 4.5 49.8 1.0
CD1 A:ILE414 4.5 68.3 1.0
C5 A:XGH501 4.6 79.2 1.0
F4 A:XGH501 4.8 77.9 1.0
CA A:LEU411 4.8 43.2 1.0
CB A:LEU411 4.8 42.4 1.0
CG A:HIS407 4.9 49.1 1.0
N A:LEU411 4.9 44.0 1.0
C4 A:XGH501 4.9 82.7 1.0

Fluorine binding site 6 out of 13 in 6bns

Go back to Fluorine Binding Sites List in 6bns
Fluorine binding site 6 out of 13 in the Structure of Human Pregnane X Receptor Ligand Binding Domain Bound Tethered with Src Co-Activator Peptide and Compound 25A Aka Bicyclic Hexafluoroisopropyl 2 Alcohol Sulfonamides


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 6 of Structure of Human Pregnane X Receptor Ligand Binding Domain Bound Tethered with Src Co-Activator Peptide and Compound 25A Aka Bicyclic Hexafluoroisopropyl 2 Alcohol Sulfonamides within 5.0Å range:
probe atom residue distance (Å) B Occ
A:F501

b:75.0
occ:1.00
 F1 A:XGH501 0.0 75.0 1.0
C21 A:XGH501 1.3 74.8 1.0
F3 A:XGH501 2.1 74.2 1.0
F2 A:XGH501 2.1 72.7 1.0
C20 A:XGH501 2.4 77.6 1.0
F5 A:XGH501 2.8 79.8 1.0
C22 A:XGH501 2.9 79.3 1.0
C2 A:XGH501 2.9 78.0 1.0
C1 A:XGH501 3.0 77.7 1.0
F6 A:XGH501 3.3 81.5 1.0
O4 A:XGH501 3.6 77.0 1.0
CZ A:PHE420 3.7 44.2 1.0
CD2 A:LEU240 3.7 49.6 1.0
CD1 A:ILE414 3.9 68.3 1.0
CE1 A:PHE420 4.1 44.6 1.0
F4 A:XGH501 4.2 77.9 1.0
C3 A:XGH501 4.2 78.8 1.0
C A:XGH501 4.4 77.5 1.0
CE2 A:PHE420 4.5 46.1 1.0
CD2 A:LEU206 4.9 84.2 1.0
S A:XGH501 4.9 75.4 1.0
NE2 A:HIS407 4.9 50.0 1.0
CA A:LEU411 4.9 43.2 1.0

Fluorine binding site 7 out of 13 in 6bns

Go back to Fluorine Binding Sites List in 6bns
Fluorine binding site 7 out of 13 in the Structure of Human Pregnane X Receptor Ligand Binding Domain Bound Tethered with Src Co-Activator Peptide and Compound 25A Aka Bicyclic Hexafluoroisopropyl 2 Alcohol Sulfonamides


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 7 of Structure of Human Pregnane X Receptor Ligand Binding Domain Bound Tethered with Src Co-Activator Peptide and Compound 25A Aka Bicyclic Hexafluoroisopropyl 2 Alcohol Sulfonamides within 5.0Å range:
probe atom residue distance (Å) B Occ
A:F501

b:99.1
occ:1.00
 F A:XGH501 0.0 99.1 1.0
C17 A:XGH501 1.4 0.2 1.0
C16 A:XGH501 2.3 99.6 1.0
C18 A:XGH501 2.3 0.1 1.0
C15 A:XGH501 3.6 0.1 1.0
C19 A:XGH501 3.6 0.1 1.0
CD2 A:TRP299 3.7 41.4 1.0
CG A:TRP299 3.8 40.8 1.0
CD2 A:PHE288 4.1 43.9 1.0
CE2 A:TRP299 4.1 44.7 1.0
C14 A:XGH501 4.1 0.6 1.0
CG A:PHE288 4.1 40.2 1.0
CE3 A:TRP299 4.1 42.9 1.0
CE2 A:PHE288 4.1 46.6 1.0
CD1 A:TRP299 4.2 43.4 1.0
CD1 A:PHE288 4.2 45.3 1.0
CZ A:PHE288 4.2 44.8 1.0
CE1 A:PHE288 4.2 47.0 1.0
CB A:TRP299 4.3 39.5 1.0
NE1 A:TRP299 4.4 42.5 1.0
CD1 A:TYR306 4.4 47.1 1.0
CG A:TYR306 4.6 45.3 1.0
CB A:TYR306 4.7 44.1 1.0
CZ2 A:TRP299 4.7 44.5 1.0
CZ3 A:TRP299 4.7 44.5 1.0
CB A:PHE288 4.8 36.9 1.0
CH2 A:TRP299 5.0 45.4 1.0

Fluorine binding site 8 out of 13 in 6bns

Go back to Fluorine Binding Sites List in 6bns
Fluorine binding site 8 out of 13 in the Structure of Human Pregnane X Receptor Ligand Binding Domain Bound Tethered with Src Co-Activator Peptide and Compound 25A Aka Bicyclic Hexafluoroisopropyl 2 Alcohol Sulfonamides


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 8 of Structure of Human Pregnane X Receptor Ligand Binding Domain Bound Tethered with Src Co-Activator Peptide and Compound 25A Aka Bicyclic Hexafluoroisopropyl 2 Alcohol Sulfonamides within 5.0Å range:
probe atom residue distance (Å) B Occ
B:F501

b:87.4
occ:1.00
 F6 B:XGH501 0.0 87.4 1.0
C22 B:XGH501 1.3 86.1 1.0
F4 B:XGH501 2.1 87.1 1.0
F5 B:XGH501 2.1 84.1 1.0
C20 B:XGH501 2.4 84.7 1.0
O4 B:XGH501 2.7 85.9 1.0
C21 B:XGH501 3.0 78.9 1.0
CE B:MET425 3.3 49.8 1.0
F2 B:XGH501 3.3 74.8 1.0
CE1 B:PHE420 3.6 61.5 1.0
C1 B:XGH501 3.7 84.9 1.0
OG B:SER247 4.0 62.0 1.0
CZ B:PHE420 4.1 60.4 1.0
CD1 B:LEU411 4.2 53.0 1.0
F3 B:XGH501 4.3 78.4 1.0
C2 B:XGH501 4.4 85.5 1.0
CB B:SER247 4.6 47.1 1.0
C B:XGH501 4.7 85.8 1.0
CD1 B:PHE420 4.7 61.1 1.0
SD B:MET425 4.7 53.3 1.0
CG B:LEU411 4.8 52.0 1.0
NE2 B:HIS407 4.8 52.8 1.0
O B:MET243 4.8 48.4 1.0
CA B:ALA244 4.8 41.8 1.0
C B:MET243 4.9 48.0 1.0
N B:ALA244 4.9 42.8 1.0
CB B:MET243 5.0 46.3 1.0

Fluorine binding site 9 out of 13 in 6bns

Go back to Fluorine Binding Sites List in 6bns
Fluorine binding site 9 out of 13 in the Structure of Human Pregnane X Receptor Ligand Binding Domain Bound Tethered with Src Co-Activator Peptide and Compound 25A Aka Bicyclic Hexafluoroisopropyl 2 Alcohol Sulfonamides


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 9 of Structure of Human Pregnane X Receptor Ligand Binding Domain Bound Tethered with Src Co-Activator Peptide and Compound 25A Aka Bicyclic Hexafluoroisopropyl 2 Alcohol Sulfonamides within 5.0Å range:
probe atom residue distance (Å) B Occ
B:F501

b:87.1
occ:1.00
 F4 B:XGH501 0.0 87.1 1.0
C22 B:XGH501 1.3 86.1 1.0
F6 B:XGH501 2.1 87.4 1.0
F5 B:XGH501 2.1 84.1 1.0
C20 B:XGH501 2.4 84.7 1.0
O4 B:XGH501 2.8 85.9 1.0
C1 B:XGH501 2.9 84.9 1.0
OG B:SER247 3.2 62.0 1.0
C B:XGH501 3.4 85.8 1.0
CB B:MET243 3.4 46.3 1.0
C2 B:XGH501 3.5 85.5 1.0
O B:MET243 3.6 48.4 1.0
C21 B:XGH501 3.8 78.9 1.0
C B:MET243 3.8 48.0 1.0
F2 B:XGH501 4.2 74.8 1.0
CA B:MET243 4.2 43.6 1.0
CB B:SER247 4.3 47.1 1.0
C5 B:XGH501 4.3 87.7 1.0
C3 B:XGH501 4.3 86.3 1.0
CG B:MET243 4.3 50.6 1.0
N B:ALA244 4.4 42.8 1.0
C4 B:XGH501 4.7 90.5 1.0
F3 B:XGH501 4.8 78.4 1.0
CA B:ALA244 4.8 41.8 1.0
CE B:MET425 4.9 49.8 1.0

Fluorine binding site 10 out of 13 in 6bns

Go back to Fluorine Binding Sites List in 6bns
Fluorine binding site 10 out of 13 in the Structure of Human Pregnane X Receptor Ligand Binding Domain Bound Tethered with Src Co-Activator Peptide and Compound 25A Aka Bicyclic Hexafluoroisopropyl 2 Alcohol Sulfonamides


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 10 of Structure of Human Pregnane X Receptor Ligand Binding Domain Bound Tethered with Src Co-Activator Peptide and Compound 25A Aka Bicyclic Hexafluoroisopropyl 2 Alcohol Sulfonamides within 5.0Å range:
probe atom residue distance (Å) B Occ
B:F501

b:84.1
occ:1.00
 F5 B:XGH501 0.0 84.1 1.0
C22 B:XGH501 1.3 86.1 1.0
F4 B:XGH501 2.1 87.1 1.0
F6 B:XGH501 2.1 87.4 1.0
C20 B:XGH501 2.4 84.7 1.0
F2 B:XGH501 2.7 74.8 1.0
C2 B:XGH501 3.0 85.5 1.0
C21 B:XGH501 3.0 78.9 1.0
C1 B:XGH501 3.0 84.9 1.0
CE1 B:PHE420 3.3 61.5 1.0
CB B:MET243 3.5 46.3 1.0
O4 B:XGH501 3.6 85.9 1.0
CD2 B:LEU240 3.6 53.8 1.0
CZ B:PHE420 4.0 60.4 1.0
C3 B:XGH501 4.1 86.3 1.0
CD1 B:PHE420 4.1 61.1 1.0
F3 B:XGH501 4.1 78.4 1.0
C B:XGH501 4.2 85.8 1.0
C B:MET243 4.4 48.0 1.0
CG B:MET243 4.4 50.6 1.0
N B:ALA244 4.5 42.8 1.0
CA B:MET243 4.6 43.6 1.0
O B:LEU240 4.7 51.9 1.0
S B:XGH501 4.7 82.9 1.0
O B:MET243 4.8 48.4 1.0
CE B:MET425 4.9 49.8 1.0
CA B:ALA244 5.0 41.8 1.0

Reference:

H.Gong, D.S.Weinstein, Z.Lu, J.J.Duan, S.Stachura, L.Haque, A.Karmakar, H.Hemagiri, D.K.Raut, A.K.Gupta, J.Khan, D.Camac, J.S.Sack, A.Pudzianowski, D.R.Wu, M.Yarde, D.R.Shen, V.Borowski, J.H.Xie, H.Sun, C.D'arienzo, M.Dabros, M.A.Galella, F.Wang, C.A.Weigelt, Q.Zhao, W.Foster, J.E.Somerville, L.M.Salter-Cid, J.C.Barrish, P.H.Carter, T.G.M.Dhar. Identification of Bicyclic Hexafluoroisopropyl Alcohol Sulfonamides As Retinoic Acid Receptor-Related Orphan Receptor Gamma (Ror Gamma /Rorc) Inverse Agonists. Employing Structure-Based Drug Design to Improve Pregnane X Receptor (Pxr) Selectivity. Bioorg. Med. Chem. Lett. V. 28 85 2018.
ISSN: ESSN 1464-3405
PubMed: 29233651
DOI: 10.1016/J.BMCL.2017.12.006
Page generated: Thu Aug 1 18:12:58 2024

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