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Fluorine in PDB 6bq0: Structure of Human Monoacylglycerol Lipase Bound to A Covalent InhibitorEnzymatic activity of Structure of Human Monoacylglycerol Lipase Bound to A Covalent Inhibitor
All present enzymatic activity of Structure of Human Monoacylglycerol Lipase Bound to A Covalent Inhibitor:
3.1.1.23; Protein crystallography data
The structure of Structure of Human Monoacylglycerol Lipase Bound to A Covalent Inhibitor, PDB code: 6bq0
was solved by
J.Pandit,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Structure of Human Monoacylglycerol Lipase Bound to A Covalent Inhibitor
(pdb code 6bq0). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 3 binding sites of Fluorine where determined in the Structure of Human Monoacylglycerol Lipase Bound to A Covalent Inhibitor, PDB code: 6bq0: Jump to Fluorine binding site number: 1; 2; 3; Fluorine binding site 1 out of 3 in 6bq0Go back to Fluorine Binding Sites List in 6bq0
Fluorine binding site 1 out
of 3 in the Structure of Human Monoacylglycerol Lipase Bound to A Covalent Inhibitor
Mono view Stereo pair view
Fluorine binding site 2 out of 3 in 6bq0Go back to Fluorine Binding Sites List in 6bq0
Fluorine binding site 2 out
of 3 in the Structure of Human Monoacylglycerol Lipase Bound to A Covalent Inhibitor
Mono view Stereo pair view
Fluorine binding site 3 out of 3 in 6bq0Go back to Fluorine Binding Sites List in 6bq0
Fluorine binding site 3 out
of 3 in the Structure of Human Monoacylglycerol Lipase Bound to A Covalent Inhibitor
Mono view Stereo pair view
Reference:
L.A.Mcallister,
C.R.Butler,
S.Mente,
S.V.O'neil,
K.R.Fonseca,
J.R.Piro,
J.A.Cianfrogna,
T.L.Foley,
A.M.Gilbert,
A.R.Harris,
C.J.Helal,
D.S.Johnson,
J.I.Montgomery,
D.M.Nason,
S.Noell,
J.Pandit,
B.N.Rogers,
T.A.Samad,
C.L.Shaffer,
R.G.Da Silva,
D.P.Uccello,
D.Webb,
M.A.Brodney.
Discovery of Trifluoromethyl Glycol Carbamates As Potent and Selective Covalent Monoacylglycerol Lipase (Magl) Inhibitors For Treatment of Neuroinflammation. J. Med. Chem. V. 61 3008 2018.
Page generated: Sun Dec 13 12:45:51 2020
ISSN: ISSN 1520-4804 PubMed: 29498843 DOI: 10.1021/ACS.JMEDCHEM.8B00070 |
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