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Fluorine in PDB 6c57: Crystal Structure of Mutant Human Geranylgeranyl Pyrophosphate Synthase (Y246D) in Complex with Bisphosphonate Inhibitor FV0109Enzymatic activity of Crystal Structure of Mutant Human Geranylgeranyl Pyrophosphate Synthase (Y246D) in Complex with Bisphosphonate Inhibitor FV0109
All present enzymatic activity of Crystal Structure of Mutant Human Geranylgeranyl Pyrophosphate Synthase (Y246D) in Complex with Bisphosphonate Inhibitor FV0109:
2.5.1.1; 2.5.1.10; 2.5.1.29; Protein crystallography data
The structure of Crystal Structure of Mutant Human Geranylgeranyl Pyrophosphate Synthase (Y246D) in Complex with Bisphosphonate Inhibitor FV0109, PDB code: 6c57
was solved by
J.Park,
X.Bin,
F.Vincent,
Y.S.Tsantrizos,
A.M.Berghuis,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structure of Mutant Human Geranylgeranyl Pyrophosphate Synthase (Y246D) in Complex with Bisphosphonate Inhibitor FV0109
(pdb code 6c57). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Crystal Structure of Mutant Human Geranylgeranyl Pyrophosphate Synthase (Y246D) in Complex with Bisphosphonate Inhibitor FV0109, PDB code: 6c57: Fluorine binding site 1 out of 1 in 6c57Go back to Fluorine Binding Sites List in 6c57
Fluorine binding site 1 out
of 1 in the Crystal Structure of Mutant Human Geranylgeranyl Pyrophosphate Synthase (Y246D) in Complex with Bisphosphonate Inhibitor FV0109
Mono view Stereo pair view
Reference:
C.M.Lacbay,
D.D.Waller,
J.Park,
M.Gomez Palou,
F.Vincent,
X.F.Huang,
V.Ta,
A.M.Berghuis,
M.Sebag,
Y.S.Tsantrizos.
Unraveling the Prenylation-Cancer Paradox in Multiple Myeloma with Novel Geranylgeranyl Pyrophosphate Synthase (Ggpps) Inhibitors. J. Med. Chem. V. 61 6904 2018.
Page generated: Sun Dec 13 12:46:19 2020
ISSN: ISSN 1520-4804 PubMed: 30016091 DOI: 10.1021/ACS.JMEDCHEM.8B00886 |
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