Fluorine in PDB 6cfp: Crystal Structure of Polymerase Acid Protein (Pa) From Influenza A Virus, Wilson-Smith/1933 (H1N1) Bound to Fragment Hit Bsi-70565 1-{1- [4-Fluorophenyl)Methyl]-2-Methyl-1H-Imidazol-4-Yl}Ethan-1-One

The structure of Crystal Structure of Polymerase Acid Protein (Pa) From Influenza A Virus, Wilson-Smith/1933 (H1N1) Bound to Fragment Hit Bsi-70565 1-{1- [4-Fluorophenyl)Methyl]-2-Methyl-1H-Imidazol-4-Yl}Ethan-1-One, PDB code: 6cfp was solved by Seattle Structural Genomics Center For Infectious Disease (Ssgcid), with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	41.13 / 2.45
Space group	P 65 2 2
Cell size a, b, c (Å), α, β, γ (°)	68.820, 68.820, 397.820, 90.00, 90.00, 120.00
R / Rfree (%)	17.9 / 23.1

The binding sites of Fluorine atom in the Crystal Structure of Polymerase Acid Protein (Pa) From Influenza A Virus, Wilson-Smith/1933 (H1N1) Bound to Fragment Hit Bsi-70565 1-{1- [4-Fluorophenyl)Methyl]-2-Methyl-1H-Imidazol-4-Yl}Ethan-1-One (pdb code 6cfp). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Crystal Structure of Polymerase Acid Protein (Pa) From Influenza A Virus, Wilson-Smith/1933 (H1N1) Bound to Fragment Hit Bsi-70565 1-{1- [4-Fluorophenyl)Methyl]-2-Methyl-1H-Imidazol-4-Yl}Ethan-1-One, PDB code: 6cfp:

Fluorine binding site 1 out of 1 in the Crystal Structure of Polymerase Acid Protein (Pa) From Influenza A Virus, Wilson-Smith/1933 (H1N1) Bound to Fragment Hit Bsi-70565 1-{1- [4-Fluorophenyl)Methyl]-2-Methyl-1H-Imidazol-4-Yl}Ethan-1-One


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Crystal Structure of Polymerase Acid Protein (Pa) From Influenza A Virus, Wilson-Smith/1933 (H1N1) Bound to Fragment Hit Bsi-70565 1-{1- [4-Fluorophenyl)Methyl]-2-Methyl-1H-Imidazol-4-Yl}Ethan-1-One within 5.0Å range: probe atom residue distance (Å) B Occ A:F801 b:84.8 occ:0.92 F17 A:EZS801 0.0 84.8 0.9 C03 A:EZS801 1.4 76.0 0.9 C02 A:EZS801 2.3 70.9 0.9 C04 A:EZS801 2.4 75.9 0.9 CB A:LEU345 3.1 45.5 1.0 O A:LEU345 3.4 51.7 1.0 C A:LEU345 3.5 50.4 1.0 C01 A:EZS801 3.6 72.4 0.9 C05 A:EZS801 3.6 76.3 0.9 OE2 A:GLU349 3.8 0.7 1.0 CA A:LEU345 3.9 46.7 1.0 N A:GLN346 4.0 47.8 1.0 CD A:GLU349 4.0 98.8 1.0 C06 A:EZS801 4.1 76.4 0.9 CG A:GLU349 4.1 94.3 1.0 CG2 A:ILE308 4.1 54.0 1.0 CG A:LEU345 4.2 51.7 1.0 CG1 A:ILE308 4.3 52.7 1.0 CD1 A:LEU345 4.3 42.8 1.0 CA A:GLN346 4.5 54.6 1.0 CB A:ILE308 4.7 57.0 1.0 OE1 A:GLU349 4.7 0.2 1.0 CD2 A:LEU345 4.7 55.5 1.0 CD1 A:ILE308 4.7 53.1 1.0 CB A:MET311 4.9 57.6 1.0 CA A:ILE308 4.9 52.8 1.0 CB A:GLU349 5.0 94.0 1.0

Seattle Structural Genomics Center For Infectious Disease(Ssgcid), D.R.Davies, J.Abendroth, D.Lorimer, P.S.Horanyi, T.E.Edwards. Crystal Structure of Polymerase Acid Protein (Pa) From Influenza A Virus, Wilson-Smith/1933 (H1N1) Bound to Fragment Hit Bsi-70565 1-{1-[4-Fluorophenyl) Methyl]-2-Methyl-1H-Imidazol-4-Yl}Ethan-1-One To Be Published.