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Fluorine in PDB 6cjf: Human Dihydroorotate Dehydrogenase Bound to 4-Quinoline Carboxylic Acid Inhibitor 43Enzymatic activity of Human Dihydroorotate Dehydrogenase Bound to 4-Quinoline Carboxylic Acid Inhibitor 43
All present enzymatic activity of Human Dihydroorotate Dehydrogenase Bound to 4-Quinoline Carboxylic Acid Inhibitor 43:
1.3.5.2; Protein crystallography data
The structure of Human Dihydroorotate Dehydrogenase Bound to 4-Quinoline Carboxylic Acid Inhibitor 43, PDB code: 6cjf
was solved by
E.M.Petrunak,
J.A.Stuckey,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 6cjf:
The structure of Human Dihydroorotate Dehydrogenase Bound to 4-Quinoline Carboxylic Acid Inhibitor 43 also contains other interesting chemical elements:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Human Dihydroorotate Dehydrogenase Bound to 4-Quinoline Carboxylic Acid Inhibitor 43
(pdb code 6cjf). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 2 binding sites of Fluorine where determined in the Human Dihydroorotate Dehydrogenase Bound to 4-Quinoline Carboxylic Acid Inhibitor 43, PDB code: 6cjf: Jump to Fluorine binding site number: 1; 2; Fluorine binding site 1 out of 2 in 6cjfGo back to Fluorine Binding Sites List in 6cjf
Fluorine binding site 1 out
of 2 in the Human Dihydroorotate Dehydrogenase Bound to 4-Quinoline Carboxylic Acid Inhibitor 43
Mono view Stereo pair view
Fluorine binding site 2 out of 2 in 6cjfGo back to Fluorine Binding Sites List in 6cjf
Fluorine binding site 2 out
of 2 in the Human Dihydroorotate Dehydrogenase Bound to 4-Quinoline Carboxylic Acid Inhibitor 43
Mono view Stereo pair view
Reference:
J.T.Madak,
C.R.Cuthbertson,
Y.Miyata,
S.Tamura,
E.M.Petrunak,
J.A.Stuckey,
Y.Han,
M.He,
D.Sun,
H.D.Showalter,
N.Neamati.
Design, Synthesis, and Biological Evaluation of 4-Quinoline Carboxylic Acids As Inhibitors of Dihydroorotate Dehydrogenase. J. Med. Chem. V. 61 5162 2018.
Page generated: Sun Dec 13 12:46:39 2020
ISSN: ISSN 1520-4804 PubMed: 29727569 DOI: 10.1021/ACS.JMEDCHEM.7B01862 |
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