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Fluorine in PDB 6d1z: Crystal Structure of Tyrosine-Protein Kinase Receptor in Complex with 5-(4-Fluorophenyl)Thieno[2,3-D]Pyrimidin-4(3H)-One InhibitorEnzymatic activity of Crystal Structure of Tyrosine-Protein Kinase Receptor in Complex with 5-(4-Fluorophenyl)Thieno[2,3-D]Pyrimidin-4(3H)-One Inhibitor
All present enzymatic activity of Crystal Structure of Tyrosine-Protein Kinase Receptor in Complex with 5-(4-Fluorophenyl)Thieno[2,3-D]Pyrimidin-4(3H)-One Inhibitor:
2.7.10.1; Protein crystallography data
The structure of Crystal Structure of Tyrosine-Protein Kinase Receptor in Complex with 5-(4-Fluorophenyl)Thieno[2,3-D]Pyrimidin-4(3H)-One Inhibitor, PDB code: 6d1z
was solved by
S.E.Greasley,
E.Johnson,
M.L.Kraus,
C.N.Cronin,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 6d1z:
The structure of Crystal Structure of Tyrosine-Protein Kinase Receptor in Complex with 5-(4-Fluorophenyl)Thieno[2,3-D]Pyrimidin-4(3H)-One Inhibitor also contains other interesting chemical elements:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structure of Tyrosine-Protein Kinase Receptor in Complex with 5-(4-Fluorophenyl)Thieno[2,3-D]Pyrimidin-4(3H)-One Inhibitor
(pdb code 6d1z). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Crystal Structure of Tyrosine-Protein Kinase Receptor in Complex with 5-(4-Fluorophenyl)Thieno[2,3-D]Pyrimidin-4(3H)-One Inhibitor, PDB code: 6d1z: Fluorine binding site 1 out of 1 in 6d1zGo back to Fluorine Binding Sites List in 6d1z
Fluorine binding site 1 out
of 1 in the Crystal Structure of Tyrosine-Protein Kinase Receptor in Complex with 5-(4-Fluorophenyl)Thieno[2,3-D]Pyrimidin-4(3H)-One Inhibitor
Mono view Stereo pair view
Reference:
S.K.Bagal,
K.Omoto,
D.C.Blakemore,
P.J.Bungay,
J.G.Bilsland,
P.J.Clarke,
M.S.Corbett,
C.N.Cronin,
J.J.Cui,
R.Dias,
N.J.Flanagan,
S.E.Greasley,
R.Grimley,
E.Johnson,
D.Fengas,
L.Kitching,
M.L.Kraus,
I.Mcalpine,
A.Nagata,
G.J.Waldron,
J.S.Warmus.
Discovery of Allosteric, Potent, Subtype Selective, and Peripherally Restricted Trka Kinase Inhibitors. J. Med. Chem. V. 62 247 2019.
Page generated: Sun Dec 13 12:47:21 2020
ISSN: ISSN 1520-4804 PubMed: 29672039 DOI: 10.1021/ACS.JMEDCHEM.8B00280 |
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