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Fluorine in PDB 6dfn: Crystal Structure of Estrogen Receptor Alpha in Complex with Receptor Degrader 16AAProtein crystallography data
The structure of Crystal Structure of Estrogen Receptor Alpha in Complex with Receptor Degrader 16AA, PDB code: 6dfn
was solved by
J.R.Kiefer,
M.Vinogradova,
J.Liang,
B.Zhang,
D.F.Ortwine,
K.W.Nettles,
J.C.Nwachukwu,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 6dfn:
The structure of Crystal Structure of Estrogen Receptor Alpha in Complex with Receptor Degrader 16AA also contains other interesting chemical elements:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structure of Estrogen Receptor Alpha in Complex with Receptor Degrader 16AA
(pdb code 6dfn). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 2 binding sites of Fluorine where determined in the Crystal Structure of Estrogen Receptor Alpha in Complex with Receptor Degrader 16AA, PDB code: 6dfn: Jump to Fluorine binding site number: 1; 2; Fluorine binding site 1 out of 2 in 6dfnGo back to Fluorine Binding Sites List in 6dfn
Fluorine binding site 1 out
of 2 in the Crystal Structure of Estrogen Receptor Alpha in Complex with Receptor Degrader 16AA
Mono view Stereo pair view
Fluorine binding site 2 out of 2 in 6dfnGo back to Fluorine Binding Sites List in 6dfn
Fluorine binding site 2 out
of 2 in the Crystal Structure of Estrogen Receptor Alpha in Complex with Receptor Degrader 16AA
Mono view Stereo pair view
Reference:
B.Zhang,
J.R.Kiefer,
R.A.Blake,
J.H.Chang,
S.Hartman,
E.R.Ingalla,
T.Kleinheinz,
V.Mody,
M.Nannini,
D.F.Ortwine,
Y.Ran,
A.Sambrone,
D.Sampath,
M.Vinogradova,
Y.Zhong,
J.C.Nwachukwu,
K.W.Nettles,
T.Lai,
J.Liao,
X.Zheng,
H.Chen,
X.Wang,
J.Liang.
Unexpected Equivalent Potency of A Constrained Chromene Enantiomeric Pair Rationalized By Co-Crystal Structures in Complex with Estrogen Receptor Alpha. Bioorg. Med. Chem. Lett. V. 29 905 2019.
Page generated: Sun Dec 13 12:47:56 2020
ISSN: ESSN 1464-3405 PubMed: 30732944 DOI: 10.1016/J.BMCL.2019.01.036 |
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