Fluorine in PDB 6diw: Crystal Structure of Hcv NS3/4A D168A Protease in Complex with P4-1 (Aj-71)

The structure of Crystal Structure of Hcv NS3/4A D168A Protease in Complex with P4-1 (Aj-71), PDB code: 6diw was solved by A.N.Matthew, C.A.Schiffer, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	26.46 / 1.80
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	55.748, 58.591, 60.111, 90.00, 90.00, 90.00
R / Rfree (%)	13.8 / 18

The structure of Crystal Structure of Hcv NS3/4A D168A Protease in Complex with P4-1 (Aj-71) also contains other interesting chemical elements:

Zinc

(Zn)

1 atom

The binding sites of Fluorine atom in the Crystal Structure of Hcv NS3/4A D168A Protease in Complex with P4-1 (Aj-71) (pdb code 6diw). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total 6 binding sites of Fluorine where determined in the Crystal Structure of Hcv NS3/4A D168A Protease in Complex with P4-1 (Aj-71), PDB code: 6diw:
Jump to Fluorine binding site number: 1; 2; 3; 4; 5; 6;

Fluorine binding site 1 out of 6 in the Crystal Structure of Hcv NS3/4A D168A Protease in Complex with P4-1 (Aj-71)


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Crystal Structure of Hcv NS3/4A D168A Protease in Complex with P4-1 (Aj-71) within 5.0Å range: probe atom residue distance (Å) B Occ A:F1201 b:24.1 occ:0.56 F53 A:GKG1201 0.0 24.1 0.6 F55 A:GKG1201 0.8 25.3 0.4 C28 A:GKG1201 1.4 10.4 0.6 C28 A:GKG1201 1.5 22.6 0.4 H272 A:GKG1201 1.7 19.7 0.4 H273 A:GKG1201 1.8 19.7 0.4 C27 A:GKG1201 1.9 16.4 0.4 C26 A:GKG1201 2.1 17.2 0.4 F55 A:GKG1201 2.2 51.9 0.6 F54 A:GKG1201 2.2 46.3 0.6 F54 A:GKG1201 2.2 25.1 0.4 C26 A:GKG1201 2.5 8.8 0.6 F53 A:GKG1201 2.6 26.2 0.4 H293 A:GKG1201 2.7 12.8 0.6 H292 A:GKG1201 2.8 12.8 0.6 C29 A:GKG1201 2.8 10.6 0.6 H271 A:GKG1201 2.9 19.7 0.4 O50 A:GKG1201 3.0 13.0 0.4 HB3 A:ALA1156 3.0 12.3 1.0 O50 A:GKG1201 3.1 12.6 0.6 C29 A:GKG1201 3.4 15.6 0.4 H292 A:GKG1201 3.5 18.7 0.4 HB1 A:ALA1156 3.6 12.3 1.0 HH22 A:ARG1155 3.7 33.8 0.5 CB A:ALA1156 3.7 10.2 1.0 C27 A:GKG1201 3.8 12.4 0.6 H291 A:GKG1201 3.8 12.8 0.6 H152 A:GKG1201 3.8 20.9 0.4 H151 A:GKG1201 3.8 22.3 0.6 H152 A:GKG1201 3.9 22.3 0.6 C25 A:GKG1201 3.9 14.6 0.4 HH12 A:ARG1155 3.9 30.4 0.5 CB A:ALA1168 3.9 30.0 1.0 H293 A:GKG1201 3.9 18.7 0.4 HH12 A:ARG1155 3.9 30.0 0.5 H273 A:GKG1201 4.0 14.9 0.6 HH21 A:ARG1123 4.0 24.4 1.0 C25 A:GKG1201 4.0 12.1 0.6 HB2 A:ALA1156 4.0 12.3 1.0 H272 A:GKG1201 4.0 14.9 0.6 NH2 A:ARG1155 4.0 28.1 0.5 H291 A:GKG1201 4.0 18.7 0.4 H151 A:GKG1201 4.0 20.9 0.4 HH11 A:ARG1155 4.1 30.0 0.5 O A:HOH1319 4.2 50.4 1.0 O49 A:GKG1201 4.2 13.9 0.6 C15 A:GKG1201 4.2 18.5 0.6 NH2 A:ARG1123 4.2 20.3 1.0 O49 A:GKG1201 4.2 12.1 0.4 NH1 A:ARG1155 4.2 25.3 0.5 NH1 A:ARG1155 4.2 25.0 0.5 C15 A:GKG1201 4.3 17.4 0.4 H153 A:GKG1201 4.3 22.3 0.6 H153 A:GKG1201 4.3 20.9 0.4 CZ A:ARG1155 4.3 27.3 0.5 O3 A:SO41205 4.4 42.2 0.9 O4 A:SO41205 4.4 46.4 0.9 HH21 A:ARG1155 4.4 33.8 0.5 HH22 A:ARG1123 4.5 24.4 1.0 H271 A:GKG1201 4.5 14.9 0.6 HE A:ARG1123 4.6 19.7 1.0 HG22 A:VAL1158 4.6 26.2 1.0 CZ A:ARG1123 4.7 20.4 1.0 HH11 A:ARG1155 4.8 30.4 0.5 HG2 A:ARG1155 4.8 21.0 0.5 NE A:ARG1123 4.8 16.4 1.0 HG2 A:ARG1155 4.8 20.3 0.5 S A:SO41205 4.9 35.4 0.9 O2 A:SO41205 4.9 25.5 0.9 N41 A:GKG1201 5.0 10.7 0.4

Fluorine binding site 2 out of 6 in the Crystal Structure of Hcv NS3/4A D168A Protease in Complex with P4-1 (Aj-71)


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 2 of Crystal Structure of Hcv NS3/4A D168A Protease in Complex with P4-1 (Aj-71) within 5.0Å range: probe atom residue distance (Å) B Occ A:F1201 b:26.2 occ:0.44 F53 A:GKG1201 0.0 26.2 0.4 H292 A:GKG1201 0.4 12.8 0.6 C29 A:GKG1201 1.3 10.6 0.6 C28 A:GKG1201 1.4 22.6 0.4 H293 A:GKG1201 1.8 12.8 0.6 H291 A:GKG1201 2.0 12.8 0.6 C26 A:GKG1201 2.3 8.8 0.6 F55 A:GKG1201 2.3 25.3 0.4 F54 A:GKG1201 2.3 25.1 0.4 C26 A:GKG1201 2.3 17.2 0.4 F55 A:GKG1201 2.4 51.9 0.6 H292 A:GKG1201 2.4 18.7 0.4 C28 A:GKG1201 2.5 10.4 0.6 H293 A:GKG1201 2.5 18.7 0.4 C29 A:GKG1201 2.5 15.6 0.4 F53 A:GKG1201 2.6 24.1 0.6 H273 A:GKG1201 2.7 14.9 0.6 HH22 A:ARG1123 2.8 24.4 1.0 C27 A:GKG1201 3.0 12.4 0.6 NH2 A:ARG1123 3.0 20.3 1.0 H273 A:GKG1201 3.2 19.7 0.4 HH21 A:ARG1123 3.2 24.4 1.0 O50 A:GKG1201 3.3 13.0 0.4 C27 A:GKG1201 3.3 16.4 0.4 O50 A:GKG1201 3.4 12.6 0.6 H291 A:GKG1201 3.5 18.7 0.4 H271 A:GKG1201 3.5 14.9 0.6 CZ A:ARG1123 3.7 20.4 1.0 H272 A:GKG1201 3.8 14.9 0.6 O A:HOH1480 3.8 43.5 1.0 H272 A:GKG1201 3.8 19.7 0.4 HG22 A:VAL1158 3.8 26.2 1.0 HH12 A:ARG1123 3.8 24.5 1.0 F54 A:GKG1201 3.8 46.3 0.6 NH1 A:ARG1123 4.0 20.4 1.0 H271 A:GKG1201 4.1 19.7 0.4 O A:HOH1554 4.2 31.1 1.0 O3 A:SO41205 4.3 42.2 0.9 O A:HOH1319 4.5 50.4 1.0 NE A:ARG1123 4.6 16.4 1.0 C25 A:GKG1201 4.6 14.6 0.4 HE A:ARG1123 4.7 19.7 1.0 C25 A:GKG1201 4.7 12.1 0.6 HH11 A:ARG1123 4.7 24.5 1.0 CG2 A:VAL1158 4.8 21.8 1.0 HG21 A:VAL1158 4.9 26.2 1.0 HG13 A:VAL1158 5.0 26.0 1.0

Fluorine binding site 3 out of 6 in the Crystal Structure of Hcv NS3/4A D168A Protease in Complex with P4-1 (Aj-71)


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 3 of Crystal Structure of Hcv NS3/4A D168A Protease in Complex with P4-1 (Aj-71) within 5.0Å range: probe atom residue distance (Å) B Occ A:F1201 b:46.3 occ:0.56 F54 A:GKG1201 0.0 46.3 0.6 C27 A:GKG1201 0.5 16.4 0.4 H271 A:GKG1201 0.8 19.7 0.4 H272 A:GKG1201 0.8 19.7 0.4 H273 A:GKG1201 1.4 19.7 0.4 C28 A:GKG1201 1.4 10.4 0.6 C26 A:GKG1201 1.9 17.2 0.4 F55 A:GKG1201 2.2 51.9 0.6 F53 A:GKG1201 2.2 24.1 0.6 H152 A:GKG1201 2.2 20.9 0.4 H152 A:GKG1201 2.4 22.3 0.6 C26 A:GKG1201 2.4 8.8 0.6 O49 A:GKG1201 2.5 12.1 0.4 O49 A:GKG1201 2.5 13.9 0.6 O50 A:GKG1201 2.6 13.0 0.4 H272 A:GKG1201 2.7 14.9 0.6 H151 A:GKG1201 2.7 22.3 0.6 C25 A:GKG1201 2.8 14.6 0.4 O50 A:GKG1201 2.9 12.6 0.6 C29 A:GKG1201 2.9 15.6 0.4 C28 A:GKG1201 2.9 22.6 0.4 H291 A:GKG1201 2.9 18.7 0.4 C25 A:GKG1201 2.9 12.1 0.6 F55 A:GKG1201 2.9 25.3 0.4 C15 A:GKG1201 3.0 18.5 0.6 C27 A:GKG1201 3.0 12.4 0.6 C15 A:GKG1201 3.0 17.4 0.4 H151 A:GKG1201 3.1 20.9 0.4 H292 A:GKG1201 3.1 18.7 0.4 O A:HOH1352 3.1 22.0 1.0 H153 A:GKG1201 3.4 20.9 0.4 HB1 A:ALA1156 3.4 12.3 1.0 H273 A:GKG1201 3.5 14.9 0.6 H153 A:GKG1201 3.5 22.3 0.6 HB3 A:ALA1156 3.6 12.3 1.0 HB2 A:ALA1156 3.6 12.3 1.0 F54 A:GKG1201 3.7 25.1 0.4 H293 A:GKG1201 3.7 18.7 0.4 C29 A:GKG1201 3.7 10.6 0.6 CB A:ALA1156 3.7 10.2 1.0 H271 A:GKG1201 3.8 14.9 0.6 F53 A:GKG1201 3.8 26.2 0.4 H292 A:GKG1201 3.9 12.8 0.6 H293 A:GKG1201 4.0 12.8 0.6 N41 A:GKG1201 4.1 10.7 0.4 C16 A:GKG1201 4.2 16.2 0.6 O44 A:GKG1201 4.2 15.5 0.6 O44 A:GKG1201 4.2 12.7 0.4 C16 A:GKG1201 4.2 17.0 0.4 N41 A:GKG1201 4.3 13.1 0.6 HH12 A:ARG1155 4.3 30.4 0.5 H291 A:GKG1201 4.4 12.8 0.6 NH1 A:ARG1155 4.4 25.3 0.5 HH11 A:ARG1155 4.6 30.4 0.5 H411 A:GKG1201 4.6 12.9 0.4 H082 A:GKG1201 4.6 10.6 0.4 H082 A:GKG1201 4.6 14.2 0.6 HH11 A:ARG1155 4.6 30.0 0.5 C01 A:GKG1201 4.7 11.4 0.6 C01 A:GKG1201 4.7 11.6 0.4 H411 A:GKG1201 4.8 15.7 0.6 CZ A:ARG1155 4.8 27.3 0.5 O A:HOH1319 4.8 50.4 1.0 C19 A:GKG1201 5.0 10.7 0.4 C09 A:GKG1201 5.0 12.4 0.4 H091 A:GKG1201 5.0 14.9 0.4

Fluorine binding site 4 out of 6 in the Crystal Structure of Hcv NS3/4A D168A Protease in Complex with P4-1 (Aj-71)


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 4 of Crystal Structure of Hcv NS3/4A D168A Protease in Complex with P4-1 (Aj-71) within 5.0Å range: probe atom residue distance (Å) B Occ A:F1201 b:25.1 occ:0.44 F54 A:GKG1201 0.0 25.1 0.4 H293 A:GKG1201 0.8 12.8 0.6 C28 A:GKG1201 1.4 22.6 0.4 C29 A:GKG1201 1.6 10.6 0.6 F55 A:GKG1201 2.1 25.3 0.4 H292 A:GKG1201 2.2 12.8 0.6 C26 A:GKG1201 2.2 8.8 0.6 F53 A:GKG1201 2.2 24.1 0.6 F53 A:GKG1201 2.3 26.2 0.4 H291 A:GKG1201 2.3 12.8 0.6 C26 A:GKG1201 2.4 17.2 0.4 O50 A:GKG1201 2.4 12.6 0.6 O50 A:GKG1201 2.4 13.0 0.4 HG22 A:VAL1158 2.5 26.2 1.0 C28 A:GKG1201 2.6 10.4 0.6 H272 A:GKG1201 3.3 19.7 0.4 CG2 A:VAL1158 3.4 21.8 1.0 C27 A:GKG1201 3.4 16.4 0.4 H293 A:GKG1201 3.5 18.7 0.4 HG23 A:VAL1158 3.5 26.2 1.0 C29 A:GKG1201 3.5 15.6 0.4 F55 A:GKG1201 3.5 51.9 0.6 HA A:VAL1158 3.6 17.0 1.0 HB3 A:ALA1156 3.7 12.3 1.0 H273 A:GKG1201 3.7 19.7 0.4 C27 A:GKG1201 3.7 12.4 0.6 F54 A:GKG1201 3.7 46.3 0.6 C25 A:GKG1201 3.7 12.1 0.6 C25 A:GKG1201 3.7 14.6 0.4 HB1 A:ALA1156 3.9 12.3 1.0 HG21 A:VAL1158 3.9 26.2 1.0 H292 A:GKG1201 3.9 18.7 0.4 H271 A:GKG1201 4.0 14.9 0.6 H273 A:GKG1201 4.0 14.9 0.6 O A:ALA1157 4.0 11.8 1.0 H411 A:GKG1201 4.1 12.9 0.4 NH2 A:ARG1123 4.2 20.3 1.0 CZ A:ARG1123 4.2 20.4 1.0 H271 A:GKG1201 4.2 19.7 0.4 CA A:VAL1158 4.2 14.2 1.0 C A:ALA1157 4.2 14.8 1.0 CB A:ALA1156 4.2 10.2 1.0 H411 A:GKG1201 4.3 15.7 0.6 H291 A:GKG1201 4.3 18.7 0.4 CB A:ALA1168 4.3 30.0 1.0 HH22 A:ARG1123 4.3 24.4 1.0 N A:VAL1158 4.3 14.8 1.0 H272 A:GKG1201 4.3 14.9 0.6 CB A:VAL1158 4.3 14.4 1.0 HH21 A:ARG1123 4.4 24.4 1.0 N41 A:GKG1201 4.4 10.7 0.4 NH1 A:ARG1123 4.4 20.4 1.0 HG13 A:VAL1158 4.4 26.0 1.0 N41 A:GKG1201 4.5 13.1 0.6 HH12 A:ARG1123 4.5 24.5 1.0 O49 A:GKG1201 4.5 13.9 0.6 O A:HOH1486 4.5 26.9 1.0 NE A:ARG1123 4.6 16.4 1.0 O49 A:GKG1201 4.6 12.1 0.4 HH11 A:ARG1123 4.7 24.5 1.0 HE A:ARG1123 4.7 19.7 1.0 H A:VAL1158 4.7 17.8 1.0 O A:HOH1554 4.7 31.1 1.0 C A:ALA1156 4.8 13.3 1.0 H A:ALA1168 4.8 11.2 1.0 O A:ALA1156 4.9 11.0 1.0 N A:ALA1157 4.9 13.5 1.0 CG1 A:VAL1158 4.9 21.6 1.0 HB2 A:ALA1156 4.9 12.3 1.0 O A:HOH1480 5.0 43.5 1.0 HD2 A:ARG1123 5.0 21.1 1.0

Fluorine binding site 5 out of 6 in the Crystal Structure of Hcv NS3/4A D168A Protease in Complex with P4-1 (Aj-71)


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 5 of Crystal Structure of Hcv NS3/4A D168A Protease in Complex with P4-1 (Aj-71) within 5.0Å range: probe atom residue distance (Å) B Occ A:F1201 b:51.9 occ:0.56 F55 A:GKG1201 0.0 51.9 0.6 H273 A:GKG1201 1.1 19.7 0.4 C28 A:GKG1201 1.4 10.4 0.6 H292 A:GKG1201 1.7 18.7 0.4 C27 A:GKG1201 1.7 16.4 0.4 C26 A:GKG1201 1.9 17.2 0.4 C29 A:GKG1201 2.1 15.6 0.4 F54 A:GKG1201 2.2 46.3 0.6 F53 A:GKG1201 2.2 24.1 0.6 C28 A:GKG1201 2.2 22.6 0.4 H271 A:GKG1201 2.2 19.7 0.4 C26 A:GKG1201 2.3 8.8 0.6 F53 A:GKG1201 2.4 26.2 0.4 F55 A:GKG1201 2.4 25.3 0.4 H273 A:GKG1201 2.4 14.9 0.6 H272 A:GKG1201 2.5 19.7 0.4 H292 A:GKG1201 2.6 12.8 0.6 H291 A:GKG1201 2.7 18.7 0.4 C27 A:GKG1201 2.7 12.4 0.6 H272 A:GKG1201 2.8 14.9 0.6 H293 A:GKG1201 2.9 18.7 0.4 C29 A:GKG1201 2.9 10.6 0.6 O50 A:GKG1201 3.3 13.0 0.4 O A:HOH1319 3.3 50.4 1.0 H293 A:GKG1201 3.5 12.8 0.6 F54 A:GKG1201 3.5 25.1 0.4 O50 A:GKG1201 3.6 12.6 0.6 H271 A:GKG1201 3.6 14.9 0.6 H291 A:GKG1201 3.7 12.8 0.6 HH12 A:ARG1155 4.0 30.4 0.5 H151 A:GKG1201 4.1 22.3 0.6 O49 A:GKG1201 4.1 12.1 0.4 O49 A:GKG1201 4.1 13.9 0.6 H152 A:GKG1201 4.1 20.9 0.4 C25 A:GKG1201 4.2 14.6 0.4 HH21 A:ARG1123 4.2 24.4 1.0 O A:HOH1352 4.2 22.0 1.0 C25 A:GKG1201 4.3 12.1 0.6 H151 A:GKG1201 4.4 20.9 0.4 HH22 A:ARG1123 4.4 24.4 1.0 H152 A:GKG1201 4.4 22.3 0.6 O3 A:SO41205 4.5 42.2 0.9 NH2 A:ARG1123 4.5 20.3 1.0 NH1 A:ARG1155 4.5 25.3 0.5 C15 A:GKG1201 4.7 18.5 0.6 C15 A:GKG1201 4.7 17.4 0.4 HH11 A:ARG1155 4.8 30.4 0.5 HH22 A:ARG1155 4.8 33.8 0.5 O4 A:SO41205 4.8 46.4 0.9 HH12 A:ARG1155 4.9 30.0 0.5 HB3 A:ALA1156 4.9 12.3 1.0

Fluorine binding site 6 out of 6 in the Crystal Structure of Hcv NS3/4A D168A Protease in Complex with P4-1 (Aj-71)


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 6 of Crystal Structure of Hcv NS3/4A D168A Protease in Complex with P4-1 (Aj-71) within 5.0Å range: probe atom residue distance (Å) B Occ A:F1201 b:25.3 occ:0.44 F55 A:GKG1201 0.0 25.3 0.4 F53 A:GKG1201 0.8 24.1 0.6 C28 A:GKG1201 1.4 22.6 0.4 C28 A:GKG1201 1.9 10.4 0.6 F54 A:GKG1201 2.1 25.1 0.4 F53 A:GKG1201 2.3 26.2 0.4 H273 A:GKG1201 2.3 19.7 0.4 F55 A:GKG1201 2.4 51.9 0.6 C26 A:GKG1201 2.5 17.2 0.4 H272 A:GKG1201 2.5 19.7 0.4 H293 A:GKG1201 2.5 12.8 0.6 H292 A:GKG1201 2.5 12.8 0.6 C27 A:GKG1201 2.5 16.4 0.4 C29 A:GKG1201 2.7 10.6 0.6 C26 A:GKG1201 2.7 8.8 0.6 F54 A:GKG1201 2.9 46.3 0.6 HH21 A:ARG1123 3.2 24.4 1.0 O50 A:GKG1201 3.4 13.0 0.4 HB3 A:ALA1156 3.5 12.3 1.0 NH2 A:ARG1123 3.5 20.3 1.0 H271 A:GKG1201 3.5 19.7 0.4 O50 A:GKG1201 3.5 12.6 0.6 H292 A:GKG1201 3.6 18.7 0.4 HH22 A:ARG1155 3.6 33.8 0.5 C29 A:GKG1201 3.6 15.6 0.4 H291 A:GKG1201 3.7 12.8 0.6 CB A:ALA1168 3.7 30.0 1.0 HH22 A:ARG1123 3.8 24.4 1.0 O3 A:SO41205 3.8 42.2 0.9 HE A:ARG1123 3.9 19.7 1.0 CZ A:ARG1123 3.9 20.4 1.0 HH12 A:ARG1155 3.9 30.0 0.5 O A:HOH1319 4.0 50.4 1.0 H293 A:GKG1201 4.0 18.7 0.4 C27 A:GKG1201 4.0 12.4 0.6 HH12 A:ARG1155 4.0 30.4 0.5 NH2 A:ARG1155 4.0 28.1 0.5 H273 A:GKG1201 4.1 14.9 0.6 NE A:ARG1123 4.1 16.4 1.0 O4 A:SO41205 4.2 46.4 0.9 HG22 A:VAL1158 4.2 26.2 1.0 HB1 A:ALA1156 4.2 12.3 1.0 CB A:ALA1156 4.2 10.2 1.0 NH1 A:ARG1155 4.3 25.0 0.5 H291 A:GKG1201 4.3 18.7 0.4 HH11 A:ARG1155 4.3 30.0 0.5 S A:SO41205 4.4 35.4 0.9 H272 A:GKG1201 4.4 14.9 0.6 O2 A:SO41205 4.4 25.5 0.9 HH21 A:ARG1155 4.5 33.8 0.5 H151 A:GKG1201 4.5 22.3 0.6 C25 A:GKG1201 4.5 14.6 0.4 NH1 A:ARG1155 4.5 25.3 0.5 C25 A:GKG1201 4.5 12.1 0.6 H152 A:GKG1201 4.5 20.9 0.4 CZ A:ARG1155 4.6 27.3 0.5 H152 A:GKG1201 4.6 22.3 0.6 HB2 A:ALA1156 4.6 12.3 1.0 H151 A:GKG1201 4.6 20.9 0.4 NH1 A:ARG1123 4.7 20.4 1.0 H271 A:GKG1201 4.7 14.9 0.6 O49 A:GKG1201 4.8 13.9 0.6 O49 A:GKG1201 4.9 12.1 0.4 C15 A:GKG1201 4.9 18.5 0.6 HH12 A:ARG1123 4.9 24.5 1.0 H153 A:GKG1201 4.9 22.3 0.6 C15 A:GKG1201 4.9 17.4 0.4 H153 A:GKG1201 5.0 20.9 0.4

A.N.Matthew, C.A.Schiffer. Design of Hepatitis C NS3/4A Protease Inhibitors Leveraging Untapped Regions of the Substrate Envelope To Be Published.