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Fluorine in PDB 6duk: Egfr with An Allosteric Inhibitor
Enzymatic activity of Egfr with An Allosteric Inhibitor
All present enzymatic activity of Egfr with An Allosteric Inhibitor:
2.7.10.1;
2.7.10.1;
Protein crystallography data
The structure of Egfr with An Allosteric Inhibitor, PDB code: 6duk
was solved by
E.Park,
M.J.Eck,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 88.50 / 2.20 |
| Space group | P 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 57.481, 94.711, 97.398, 70.38, 77.46, 79.14 |
| R / Rfree (%) | 19 / 22.3 |
Other elements in 6duk:
The structure of Egfr with An Allosteric Inhibitor also contains other interesting chemical elements:
| Magnesium | (Mg) | 6 atoms |
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Egfr with An Allosteric Inhibitor
(pdb code 6duk). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 6 binding sites of Fluorine where determined in the Egfr with An Allosteric Inhibitor, PDB code: 6duk:
Jump to Fluorine binding site number: 1; 2; 3; 4; 5; 6;
In total 6 binding sites of Fluorine where determined in the Egfr with An Allosteric Inhibitor, PDB code: 6duk:
Jump to Fluorine binding site number: 1; 2; 3; 4; 5; 6;
Fluorine binding site 1 out of 6 in 6duk
Go back to
Fluorine Binding Sites List in 6duk
Fluorine binding site 1 out
of 6 in the Egfr with An Allosteric Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 1 of Egfr with An Allosteric Inhibitor within 5.0Å range:
|
Fluorine binding site 2 out of 6 in 6duk
Go back to
Fluorine Binding Sites List in 6duk
Fluorine binding site 2 out
of 6 in the Egfr with An Allosteric Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 2 of Egfr with An Allosteric Inhibitor within 5.0Å range:
|
Fluorine binding site 3 out of 6 in 6duk
Go back to
Fluorine Binding Sites List in 6duk
Fluorine binding site 3 out
of 6 in the Egfr with An Allosteric Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 3 of Egfr with An Allosteric Inhibitor within 5.0Å range:
|
Fluorine binding site 4 out of 6 in 6duk
Go back to
Fluorine Binding Sites List in 6duk
Fluorine binding site 4 out
of 6 in the Egfr with An Allosteric Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 4 of Egfr with An Allosteric Inhibitor within 5.0Å range:
|
Fluorine binding site 5 out of 6 in 6duk
Go back to
Fluorine Binding Sites List in 6duk
Fluorine binding site 5 out
of 6 in the Egfr with An Allosteric Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 5 of Egfr with An Allosteric Inhibitor within 5.0Å range:
|
Fluorine binding site 6 out of 6 in 6duk
Go back to
Fluorine Binding Sites List in 6duk
Fluorine binding site 6 out
of 6 in the Egfr with An Allosteric Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 6 of Egfr with An Allosteric Inhibitor within 5.0Å range:
|
Reference:
C.To,
J.Jang,
T.Chen,
E.Park,
M.Mushajiang,
D.J.H.De Clercq,
M.Xu,
S.Wang,
M.D.Cameron,
D.E.Heppner,
B.H.Shin,
T.W.Gero,
A.Yang,
S.E.Dahlberg,
K.K.Wong,
M.J.Eck,
N.S.Gray,
P.A.Janne.
Single and Dual Targeting of Mutant Egfr with An Allosteric Inhibitor. Cancer Discov V. 9 926 2019.
ISSN: ESSN 2159-8290
PubMed: 31092401
DOI: 10.1158/2159-8290.CD-18-0903
Page generated: Thu Aug 1 19:11:31 2024
ISSN: ESSN 2159-8290
PubMed: 31092401
DOI: 10.1158/2159-8290.CD-18-0903
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