Fluorine »
PDB 6dkw-6e5g »
6duk »
Fluorine in PDB 6duk: Egfr with An Allosteric Inhibitor
Enzymatic activity of Egfr with An Allosteric Inhibitor
All present enzymatic activity of Egfr with An Allosteric Inhibitor:
2.7.10.1;
2.7.10.1;
Protein crystallography data
The structure of Egfr with An Allosteric Inhibitor, PDB code: 6duk
was solved by
E.Park,
M.J.Eck,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 88.50 / 2.20 |
| Space group | P 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 57.481, 94.711, 97.398, 70.38, 77.46, 79.14 |
| R / Rfree (%) | 19 / 22.3 |
Other elements in 6duk:
The structure of Egfr with An Allosteric Inhibitor also contains other interesting chemical elements:
| Magnesium | (Mg) | 6 atoms |
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Egfr with An Allosteric Inhibitor
(pdb code 6duk). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 6 binding sites of Fluorine where determined in the Egfr with An Allosteric Inhibitor, PDB code: 6duk:
Jump to Fluorine binding site number: 1; 2; 3; 4; 5; 6;
In total 6 binding sites of Fluorine where determined in the Egfr with An Allosteric Inhibitor, PDB code: 6duk:
Jump to Fluorine binding site number: 1; 2; 3; 4; 5; 6;
Fluorine binding site 1 out of 6 in 6duk
Go back to
Fluorine Binding Sites List in 6duk
Fluorine binding site 1 out
of 6 in the Egfr with An Allosteric Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 1 of Egfr with An Allosteric Inhibitor within 5.0Å range:
|
Fluorine binding site 2 out of 6 in 6duk
Go back to
Fluorine Binding Sites List in 6duk
Fluorine binding site 2 out
of 6 in the Egfr with An Allosteric Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 2 of Egfr with An Allosteric Inhibitor within 5.0Å range:
|
Fluorine binding site 3 out of 6 in 6duk
Go back to
Fluorine Binding Sites List in 6duk
Fluorine binding site 3 out
of 6 in the Egfr with An Allosteric Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 3 of Egfr with An Allosteric Inhibitor within 5.0Å range:
|
Fluorine binding site 4 out of 6 in 6duk
Go back to
Fluorine Binding Sites List in 6duk
Fluorine binding site 4 out
of 6 in the Egfr with An Allosteric Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 4 of Egfr with An Allosteric Inhibitor within 5.0Å range:
|
Fluorine binding site 5 out of 6 in 6duk
Go back to
Fluorine Binding Sites List in 6duk
Fluorine binding site 5 out
of 6 in the Egfr with An Allosteric Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 5 of Egfr with An Allosteric Inhibitor within 5.0Å range:
|
Fluorine binding site 6 out of 6 in 6duk
Go back to
Fluorine Binding Sites List in 6duk
Fluorine binding site 6 out
of 6 in the Egfr with An Allosteric Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 6 of Egfr with An Allosteric Inhibitor within 5.0Å range:
|
Reference:
C.To,
J.Jang,
T.Chen,
E.Park,
M.Mushajiang,
D.J.H.De Clercq,
M.Xu,
S.Wang,
M.D.Cameron,
D.E.Heppner,
B.H.Shin,
T.W.Gero,
A.Yang,
S.E.Dahlberg,
K.K.Wong,
M.J.Eck,
N.S.Gray,
P.A.Janne.
Single and Dual Targeting of Mutant Egfr with An Allosteric Inhibitor. Cancer Discov V. 9 926 2019.
ISSN: ESSN 2159-8290
PubMed: 31092401
DOI: 10.1158/2159-8290.CD-18-0903
Page generated: Thu Aug 1 19:11:31 2024
ISSN: ESSN 2159-8290
PubMed: 31092401
DOI: 10.1158/2159-8290.CD-18-0903
Last articles
Zn in 9JPJZn in 9JP7
Zn in 9JPK
Zn in 9JPL
Zn in 9GN6
Zn in 9GN7
Zn in 9GKU
Zn in 9GKW
Zn in 9GKX
Zn in 9GL0
