Fluorine in PDB 6dzw: Cryo-Em Structure of the TS2-Inactive Human Serotonin Transporter in Complex with Paroxetine and 15B8 Fab and 8B6 Scfv

The binding sites of Fluorine atom in the Cryo-Em Structure of the TS2-Inactive Human Serotonin Transporter in Complex with Paroxetine and 15B8 Fab and 8B6 Scfv (pdb code 6dzw). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Cryo-Em Structure of the TS2-Inactive Human Serotonin Transporter in Complex with Paroxetine and 15B8 Fab and 8B6 Scfv, PDB code: 6dzw:

Fluorine binding site 1 out of 1 in the Cryo-Em Structure of the TS2-Inactive Human Serotonin Transporter in Complex with Paroxetine and 15B8 Fab and 8B6 Scfv


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Cryo-Em Structure of the TS2-Inactive Human Serotonin Transporter in Complex with Paroxetine and 15B8 Fab and 8B6 Scfv within 5.0Å range: probe atom residue distance (Å) B Occ A:F701 b:0.6 occ:1.00 FAA A:8PR701 0.0 0.6 1.0 CAR A:8PR701 1.4 0.6 1.0 CAB A:8PR701 2.3 0.6 1.0 CAC A:8PR701 2.4 0.6 1.0 O A:THR497 3.5 0.0 1.0 CAE A:8PR701 3.6 0.6 1.0 CAF A:8PR701 3.7 0.6 1.0 CG1 A:VAL501 4.0 0.2 1.0 OE2 A:GLU493 4.0 1.0 1.0 CAT A:8PR701 4.1 0.6 1.0 CE1 A:PHE335 4.4 0.3 1.0 C A:THR497 4.4 0.0 1.0 CB A:VAL501 4.4 0.2 1.0 CZ A:PHE335 4.5 0.3 1.0 CB A:THR497 4.7 0.0 1.0 CD1 A:PHE335 4.7 0.3 1.0 OG1 A:THR497 4.8 0.0 1.0 CG2 A:VAL501 4.9 0.2 1.0 OH A:TYR175 4.9 0.4 1.0 CE2 A:PHE335 4.9 0.3 1.0

J.A.Coleman, D.Yang, Z.Zhao, P.C.Wen, C.Yoshioka, E.Tajkhorshid, E.Gouaux. Serotonin Transporter-Ibogaine Complexes Illuminate Mechanisms of Inhibition and Transport. Nature V. 569 141 2019.
ISSN: ESSN 1476-4687
PubMed: 31019304
DOI: 10.1038/S41586-019-1135-1