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Fluorine in PDB 6e4w: Structure of Ampk Bound to ActivatorEnzymatic activity of Structure of Ampk Bound to Activator
All present enzymatic activity of Structure of Ampk Bound to Activator:
2.7.11.1; 2.7.11.26; 2.7.11.27; 2.7.11.31; Protein crystallography data
The structure of Structure of Ampk Bound to Activator, PDB code: 6e4w
was solved by
M.F.Calabrese,
R.G.Kurumbail,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 6e4w:
The structure of Structure of Ampk Bound to Activator also contains other interesting chemical elements:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Structure of Ampk Bound to Activator
(pdb code 6e4w). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 2 binding sites of Fluorine where determined in the Structure of Ampk Bound to Activator, PDB code: 6e4w: Jump to Fluorine binding site number: 1; 2; Fluorine binding site 1 out of 2 in 6e4wGo back to Fluorine Binding Sites List in 6e4w
Fluorine binding site 1 out
of 2 in the Structure of Ampk Bound to Activator
Mono view Stereo pair view
Fluorine binding site 2 out of 2 in 6e4wGo back to Fluorine Binding Sites List in 6e4w
Fluorine binding site 2 out
of 2 in the Structure of Ampk Bound to Activator
Mono view Stereo pair view
Reference:
T.F.Ryder,
M.F.Calabrese,
G.S.Walker,
K.O.Cameron,
A.R.Reyes,
K.A.Borzilleri,
J.Delmore,
R.Miller,
R.G.Kurumbail,
J.Ward,
D.W.Kung,
J.A.Brown,
D.J.Edmonds,
H.Eng,
A.C.Wolford,
A.S.Kalgutkar.
Acyl Glucuronide Metabolites of 6-Chloro-5-[4-(1-Hydroxycyclobutyl)Phenyl]-1 H-Indole-3-Carboxylic Acid (Pf-06409577) and Related Indole-3-Carboxylic Acid Derivatives Are Direct Activators of Adenosine Monophosphate-Activated Protein Kinase (Ampk). J. Med. Chem. V. 61 7273 2018.
Page generated: Sun Dec 13 12:48:48 2020
ISSN: ISSN 1520-4804 PubMed: 30036059 DOI: 10.1021/ACS.JMEDCHEM.8B00807 |
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