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Fluorine in PDB 6eeh: Bioreductive 4-Hydroxy-3-Nitro-5-Ureido-Benzenesulfonamides Selectively Target the Tumor-Associated Carbonic Anhydrase Isoforms IX and XII and Show Hypoxia-Enhanced Cytotoxicity Against Human Cancer Cell Lines.

Enzymatic activity of Bioreductive 4-Hydroxy-3-Nitro-5-Ureido-Benzenesulfonamides Selectively Target the Tumor-Associated Carbonic Anhydrase Isoforms IX and XII and Show Hypoxia-Enhanced Cytotoxicity Against Human Cancer Cell Lines.

All present enzymatic activity of Bioreductive 4-Hydroxy-3-Nitro-5-Ureido-Benzenesulfonamides Selectively Target the Tumor-Associated Carbonic Anhydrase Isoforms IX and XII and Show Hypoxia-Enhanced Cytotoxicity Against Human Cancer Cell Lines.:
4.2.1.1;

Protein crystallography data

The structure of Bioreductive 4-Hydroxy-3-Nitro-5-Ureido-Benzenesulfonamides Selectively Target the Tumor-Associated Carbonic Anhydrase Isoforms IX and XII and Show Hypoxia-Enhanced Cytotoxicity Against Human Cancer Cell Lines., PDB code: 6eeh was solved by S.Singh, R.Mckenna, C.T.Supuran, A.Nocentini, C.Lomelino, E.Lucarini, G.Bartolucci, L.D.C.Mannelli, C.Ghelardini, P.Gratteri, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 29.37 / 1.63
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 42.571, 41.795, 72.889, 90.00, 104.13, 90.00
R / Rfree (%) 16 / 18.7

Other elements in 6eeh:

The structure of Bioreductive 4-Hydroxy-3-Nitro-5-Ureido-Benzenesulfonamides Selectively Target the Tumor-Associated Carbonic Anhydrase Isoforms IX and XII and Show Hypoxia-Enhanced Cytotoxicity Against Human Cancer Cell Lines. also contains other interesting chemical elements:

Zinc (Zn) 1 atom

Fluorine Binding Sites:

Pages:

>>> Page 1 <<< Page 2, Binding sites: 11 - 15;

Binding sites:

The binding sites of Fluorine atom in the Bioreductive 4-Hydroxy-3-Nitro-5-Ureido-Benzenesulfonamides Selectively Target the Tumor-Associated Carbonic Anhydrase Isoforms IX and XII and Show Hypoxia-Enhanced Cytotoxicity Against Human Cancer Cell Lines. (pdb code 6eeh). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total 15 binding sites of Fluorine where determined in the Bioreductive 4-Hydroxy-3-Nitro-5-Ureido-Benzenesulfonamides Selectively Target the Tumor-Associated Carbonic Anhydrase Isoforms IX and XII and Show Hypoxia-Enhanced Cytotoxicity Against Human Cancer Cell Lines., PDB code: 6eeh:
Jump to Fluorine binding site number: 1; 2; 3; 4; 5; 6; 7; 8; 9; 10;

Fluorine binding site 1 out of 15 in 6eeh

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Fluorine binding site 1 out of 15 in the Bioreductive 4-Hydroxy-3-Nitro-5-Ureido-Benzenesulfonamides Selectively Target the Tumor-Associated Carbonic Anhydrase Isoforms IX and XII and Show Hypoxia-Enhanced Cytotoxicity Against Human Cancer Cell Lines.


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Bioreductive 4-Hydroxy-3-Nitro-5-Ureido-Benzenesulfonamides Selectively Target the Tumor-Associated Carbonic Anhydrase Isoforms IX and XII and Show Hypoxia-Enhanced Cytotoxicity Against Human Cancer Cell Lines. within 5.0Å range:
probe atom residue distance (Å) B Occ
A:F302

b:29.1
occ:1.00
 F18 A:J4D302 0.0 29.1 1.0
C17 A:J4D302 1.4 33.6 1.0
C12 A:J4D302 2.4 36.4 1.0
C16 A:J4D302 2.4 35.7 1.0
N10 A:J4D302 2.7 37.9 1.0
F19 A:J4D302 2.8 36.1 1.0
O11 A:J4D302 2.8 28.4 1.0
C09 A:J4D302 2.9 32.6 1.0
O A:HOH417 3.1 35.3 1.0
CD A:PRO202 3.2 13.3 1.0
C05 A:J4D303 3.5 48.2 1.0
C04 A:J4D303 3.5 47.8 1.0
C13 A:J4D302 3.6 36.9 1.0
C15 A:J4D302 3.6 38.5 1.0
N08 A:J4D303 3.8 50.4 1.0
CG A:PRO202 4.1 15.3 1.0
C06 A:J4D303 4.1 47.9 1.0
N08 A:J4D302 4.1 28.6 1.0
C14 A:J4D302 4.1 36.1 1.0
CD1 A:LEU198 4.2 16.8 1.0
O A:PRO201 4.2 15.0 1.0
C03 A:J4D303 4.2 53.5 1.0
C09 A:J4D303 4.2 55.7 1.0
N29 A:J4D303 4.3 52.7 1.0
O11 A:J4D303 4.3 55.8 1.0
N A:PRO202 4.5 12.0 1.0
C01 A:J4D303 4.6 43.2 1.0
C02 A:J4D303 4.7 51.1 1.0
F22 A:J4D302 4.7 39.1 1.0
F20 A:J4D302 4.8 42.9 1.0
C A:PRO201 4.8 11.1 1.0
S26 A:J4D303 4.9 57.0 1.0
O07 A:J4D303 4.9 50.9 1.0

Fluorine binding site 2 out of 15 in 6eeh

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Fluorine binding site 2 out of 15 in the Bioreductive 4-Hydroxy-3-Nitro-5-Ureido-Benzenesulfonamides Selectively Target the Tumor-Associated Carbonic Anhydrase Isoforms IX and XII and Show Hypoxia-Enhanced Cytotoxicity Against Human Cancer Cell Lines.


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 2 of Bioreductive 4-Hydroxy-3-Nitro-5-Ureido-Benzenesulfonamides Selectively Target the Tumor-Associated Carbonic Anhydrase Isoforms IX and XII and Show Hypoxia-Enhanced Cytotoxicity Against Human Cancer Cell Lines. within 5.0Å range:
probe atom residue distance (Å) B Occ
A:F302

b:36.1
occ:1.00
 F19 A:J4D302 0.0 36.1 1.0
C16 A:J4D302 1.4 35.7 1.0
C15 A:J4D302 2.4 38.5 1.0
C17 A:J4D302 2.4 33.6 1.0
F20 A:J4D302 2.7 42.9 1.0
F18 A:J4D302 2.8 29.1 1.0
CG A:PRO202 3.2 15.3 1.0
F18 A:J4D304 3.2 44.4 1.0
O07 A:J4D303 3.4 50.9 1.0
CD A:PRO202 3.5 13.3 1.0
C03 A:J4D303 3.5 53.5 1.0
N08 A:J4D303 3.5 50.4 1.0
C04 A:J4D303 3.6 47.8 1.0
C14 A:J4D302 3.6 36.1 1.0
C12 A:J4D302 3.6 36.4 1.0
N10 A:J4D304 3.6 39.8 1.0
N08 A:J4D304 4.0 39.8 1.0
CG1 A:VAL135 4.0 22.6 1.0
C09 A:J4D304 4.0 40.7 1.0
C13 A:J4D302 4.1 36.9 1.0
C17 A:J4D304 4.2 43.8 1.0
C02 A:J4D303 4.3 51.1 1.0
C05 A:J4D303 4.4 48.2 1.0
C12 A:J4D304 4.4 43.5 1.0
CB A:PRO202 4.5 15.2 1.0
O25 A:J4D303 4.6 54.5 1.0
C09 A:J4D303 4.6 55.7 1.0
O07 A:J4D304 4.6 35.3 1.0
CG2 A:VAL135 4.7 19.7 1.0
CB A:VAL135 4.7 15.5 1.0
F21 A:J4D302 4.7 37.0 1.0
CD1 A:LEU198 4.7 16.8 1.0
N10 A:J4D302 4.8 37.9 1.0
O11 A:J4D304 4.8 37.7 1.0
N23 A:J4D303 4.9 57.2 1.0
C04 A:J4D304 4.9 39.9 1.0
N A:PRO202 4.9 12.0 1.0
C01 A:J4D303 5.0 43.2 1.0

Fluorine binding site 3 out of 15 in 6eeh

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Fluorine binding site 3 out of 15 in the Bioreductive 4-Hydroxy-3-Nitro-5-Ureido-Benzenesulfonamides Selectively Target the Tumor-Associated Carbonic Anhydrase Isoforms IX and XII and Show Hypoxia-Enhanced Cytotoxicity Against Human Cancer Cell Lines.


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 3 of Bioreductive 4-Hydroxy-3-Nitro-5-Ureido-Benzenesulfonamides Selectively Target the Tumor-Associated Carbonic Anhydrase Isoforms IX and XII and Show Hypoxia-Enhanced Cytotoxicity Against Human Cancer Cell Lines. within 5.0Å range:
probe atom residue distance (Å) B Occ
A:F302

b:42.9
occ:1.00
 F20 A:J4D302 0.0 42.9 1.0
C15 A:J4D302 1.4 38.5 1.0
C14 A:J4D302 2.4 36.1 1.0
C16 A:J4D302 2.4 35.7 1.0
F21 A:J4D302 2.7 37.0 1.0
F19 A:J4D302 2.7 36.1 1.0
N08 A:J4D304 3.2 39.8 1.0
CG2 A:VAL135 3.3 19.7 1.0
C04 A:J4D304 3.4 39.9 1.0
CB A:VAL135 3.4 15.5 1.0
C03 A:J4D304 3.6 37.6 1.0
CG1 A:VAL135 3.6 22.6 1.0
C17 A:J4D302 3.6 33.6 1.0
C13 A:J4D302 3.6 36.9 1.0
O07 A:J4D304 3.7 35.3 1.0
C09 A:J4D304 3.7 40.7 1.0
CA A:GLY132 4.1 17.5 1.0
C05 A:J4D304 4.1 38.2 1.0
O11 A:J4D304 4.1 37.7 1.0
C12 A:J4D302 4.1 36.4 1.0
F18 A:J4D304 4.2 44.4 1.0
N10 A:J4D304 4.3 39.8 1.0
O A:GLY132 4.3 22.4 1.0
N08 A:J4D303 4.3 50.4 1.0
C02 A:J4D304 4.5 41.8 1.0
O07 A:J4D303 4.6 50.9 1.0
O A:VAL131 4.6 14.4 1.0
NE2 A:GLN136 4.6 44.1 1.0
C A:GLY132 4.7 20.7 1.0
F22 A:J4D302 4.8 39.1 1.0
F18 A:J4D302 4.8 29.1 1.0
N10 A:J4D303 4.8 57.0 1.0
C06 A:J4D304 4.8 37.9 1.0
N A:GLY132 4.9 16.6 1.0
CA A:VAL135 4.9 13.1 1.0
C09 A:J4D303 5.0 55.7 1.0

Fluorine binding site 4 out of 15 in 6eeh

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Fluorine binding site 4 out of 15 in the Bioreductive 4-Hydroxy-3-Nitro-5-Ureido-Benzenesulfonamides Selectively Target the Tumor-Associated Carbonic Anhydrase Isoforms IX and XII and Show Hypoxia-Enhanced Cytotoxicity Against Human Cancer Cell Lines.


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 4 of Bioreductive 4-Hydroxy-3-Nitro-5-Ureido-Benzenesulfonamides Selectively Target the Tumor-Associated Carbonic Anhydrase Isoforms IX and XII and Show Hypoxia-Enhanced Cytotoxicity Against Human Cancer Cell Lines. within 5.0Å range:
probe atom residue distance (Å) B Occ
A:F302

b:37.0
occ:1.00
 F21 A:J4D302 0.0 37.0 1.0
C14 A:J4D302 1.4 36.1 1.0
C15 A:J4D302 2.4 38.5 1.0
C13 A:J4D302 2.4 36.9 1.0
F20 A:J4D302 2.7 42.9 1.0
F22 A:J4D302 2.8 39.1 1.0
F22 A:J4D303 3.1 65.6 1.0
CG1 A:VAL131 3.4 16.7 1.0
O A:VAL131 3.5 14.4 1.0
C A:VAL131 3.5 18.0 1.0
N A:GLY132 3.5 16.6 1.0
CG2 A:VAL131 3.6 12.4 1.0
CA A:GLY132 3.6 17.5 1.0
C16 A:J4D302 3.6 35.7 1.0
CG2 A:VAL135 3.6 19.7 1.0
C12 A:J4D302 3.6 36.4 1.0
CB A:VAL131 4.0 13.2 1.0
C17 A:J4D302 4.1 33.6 1.0
N10 A:J4D303 4.3 57.0 1.0
CA A:VAL131 4.4 14.5 1.0
C13 A:J4D303 4.4 68.0 1.0
O07 A:J4D304 4.4 35.3 1.0
C03 A:J4D304 4.4 37.6 1.0
CB A:VAL135 4.6 15.5 1.0
C02 A:J4D304 4.6 41.8 1.0
F19 A:J4D302 4.7 36.1 1.0
N23 A:J4D304 4.7 48.2 1.0
C A:GLY132 4.8 20.7 1.0
C12 A:J4D303 4.8 64.1 1.0
O24 A:J4D304 4.9 50.8 1.0
N10 A:J4D302 4.9 37.9 1.0
C04 A:J4D304 4.9 39.9 1.0

Fluorine binding site 5 out of 15 in 6eeh

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Fluorine binding site 5 out of 15 in the Bioreductive 4-Hydroxy-3-Nitro-5-Ureido-Benzenesulfonamides Selectively Target the Tumor-Associated Carbonic Anhydrase Isoforms IX and XII and Show Hypoxia-Enhanced Cytotoxicity Against Human Cancer Cell Lines.


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 5 of Bioreductive 4-Hydroxy-3-Nitro-5-Ureido-Benzenesulfonamides Selectively Target the Tumor-Associated Carbonic Anhydrase Isoforms IX and XII and Show Hypoxia-Enhanced Cytotoxicity Against Human Cancer Cell Lines. within 5.0Å range:
probe atom residue distance (Å) B Occ
A:F302

b:39.1
occ:1.00
 F22 A:J4D302 0.0 39.1 1.0
C13 A:J4D302 1.4 36.9 1.0
C12 A:J4D302 2.4 36.4 1.0
C14 A:J4D302 2.4 36.1 1.0
F21 A:J4D302 2.8 37.0 1.0
N10 A:J4D302 2.8 37.9 1.0
F22 A:J4D303 2.9 65.6 1.0
C13 A:J4D303 3.6 68.0 1.0
C17 A:J4D302 3.6 33.6 1.0
C15 A:J4D302 3.6 38.5 1.0
C09 A:J4D302 4.0 32.6 1.0
CG2 A:VAL131 4.0 12.4 1.0
CD2 A:LEU91 4.0 29.1 1.0
CG1 A:VAL131 4.1 16.7 1.0
C16 A:J4D302 4.1 35.7 1.0
C12 A:J4D303 4.2 64.1 1.0
N10 A:J4D303 4.2 57.0 1.0
C14 A:J4D303 4.4 71.1 1.0
O11 A:J4D302 4.4 28.4 1.0
F21 A:J4D303 4.5 69.5 1.0
CB A:VAL131 4.7 13.2 1.0
C09 A:J4D303 4.7 55.7 1.0
F18 A:J4D302 4.7 29.1 1.0
F20 A:J4D302 4.8 42.9 1.0
N08 A:J4D302 4.9 28.6 1.0

Fluorine binding site 6 out of 15 in 6eeh

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Fluorine binding site 6 out of 15 in the Bioreductive 4-Hydroxy-3-Nitro-5-Ureido-Benzenesulfonamides Selectively Target the Tumor-Associated Carbonic Anhydrase Isoforms IX and XII and Show Hypoxia-Enhanced Cytotoxicity Against Human Cancer Cell Lines.


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 6 of Bioreductive 4-Hydroxy-3-Nitro-5-Ureido-Benzenesulfonamides Selectively Target the Tumor-Associated Carbonic Anhydrase Isoforms IX and XII and Show Hypoxia-Enhanced Cytotoxicity Against Human Cancer Cell Lines. within 5.0Å range:
probe atom residue distance (Å) B Occ
A:F303

b:71.0
occ:1.00
 F18 A:J4D303 0.0 71.0 1.0
C17 A:J4D303 1.4 70.5 1.0
O11 A:J4D303 2.3 55.8 1.0
C16 A:J4D303 2.4 77.8 1.0
C12 A:J4D303 2.4 64.1 1.0
F19 A:J4D303 2.7 86.2 1.0
C09 A:J4D303 2.8 55.7 1.0
N10 A:J4D303 2.8 57.0 1.0
C15 A:J4D303 3.6 75.7 1.0
C13 A:J4D303 3.7 68.0 1.0
N08 A:J4D303 4.0 50.4 1.0
C14 A:J4D303 4.1 71.1 1.0
O24 A:J4D304 4.7 50.8 1.0
F20 A:J4D303 4.7 77.0 1.0
C05 A:J4D303 4.8 48.2 1.0
C04 A:J4D303 4.8 47.8 1.0
F22 A:J4D303 4.8 65.6 1.0

Fluorine binding site 7 out of 15 in 6eeh

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Fluorine binding site 7 out of 15 in the Bioreductive 4-Hydroxy-3-Nitro-5-Ureido-Benzenesulfonamides Selectively Target the Tumor-Associated Carbonic Anhydrase Isoforms IX and XII and Show Hypoxia-Enhanced Cytotoxicity Against Human Cancer Cell Lines.


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 7 of Bioreductive 4-Hydroxy-3-Nitro-5-Ureido-Benzenesulfonamides Selectively Target the Tumor-Associated Carbonic Anhydrase Isoforms IX and XII and Show Hypoxia-Enhanced Cytotoxicity Against Human Cancer Cell Lines. within 5.0Å range:
probe atom residue distance (Å) B Occ
A:F303

b:86.2
occ:1.00
 F19 A:J4D303 0.0 86.2 1.0
C16 A:J4D303 1.4 77.8 1.0
C17 A:J4D303 2.4 70.5 1.0
C15 A:J4D303 2.4 75.7 1.0
F18 A:J4D303 2.7 71.0 1.0
F20 A:J4D303 2.8 77.0 1.0
C12 A:J4D303 3.6 64.1 1.0
C14 A:J4D303 3.6 71.1 1.0
C13 A:J4D303 4.1 68.0 1.0
O11 A:J4D303 4.7 55.8 1.0
F21 A:J4D303 4.8 69.5 1.0
N10 A:J4D303 4.8 57.0 1.0

Fluorine binding site 8 out of 15 in 6eeh

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Fluorine binding site 8 out of 15 in the Bioreductive 4-Hydroxy-3-Nitro-5-Ureido-Benzenesulfonamides Selectively Target the Tumor-Associated Carbonic Anhydrase Isoforms IX and XII and Show Hypoxia-Enhanced Cytotoxicity Against Human Cancer Cell Lines.


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 8 of Bioreductive 4-Hydroxy-3-Nitro-5-Ureido-Benzenesulfonamides Selectively Target the Tumor-Associated Carbonic Anhydrase Isoforms IX and XII and Show Hypoxia-Enhanced Cytotoxicity Against Human Cancer Cell Lines. within 5.0Å range:
probe atom residue distance (Å) B Occ
A:F303

b:77.0
occ:1.00
 F20 A:J4D303 0.0 77.0 1.0
C15 A:J4D303 1.4 75.7 1.0
C16 A:J4D303 2.4 77.8 1.0
C14 A:J4D303 2.4 71.1 1.0
F21 A:J4D303 2.7 69.5 1.0
F19 A:J4D303 2.8 86.2 1.0
C17 A:J4D303 3.6 70.5 1.0
C13 A:J4D303 3.6 68.0 1.0
C12 A:J4D303 4.1 64.1 1.0
F18 A:J4D303 4.7 71.0 1.0
F22 A:J4D303 4.8 65.6 1.0

Fluorine binding site 9 out of 15 in 6eeh

Go back to Fluorine Binding Sites List in 6eeh
Fluorine binding site 9 out of 15 in the Bioreductive 4-Hydroxy-3-Nitro-5-Ureido-Benzenesulfonamides Selectively Target the Tumor-Associated Carbonic Anhydrase Isoforms IX and XII and Show Hypoxia-Enhanced Cytotoxicity Against Human Cancer Cell Lines.


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 9 of Bioreductive 4-Hydroxy-3-Nitro-5-Ureido-Benzenesulfonamides Selectively Target the Tumor-Associated Carbonic Anhydrase Isoforms IX and XII and Show Hypoxia-Enhanced Cytotoxicity Against Human Cancer Cell Lines. within 5.0Å range:
probe atom residue distance (Å) B Occ
A:F303

b:69.5
occ:1.00
 F21 A:J4D303 0.0 69.5 1.0
C14 A:J4D303 1.4 71.1 1.0
C15 A:J4D303 2.4 75.7 1.0
C13 A:J4D303 2.4 68.0 1.0
F22 A:J4D303 2.7 65.6 1.0
F20 A:J4D303 2.7 77.0 1.0
C16 A:J4D303 3.6 77.8 1.0
C12 A:J4D303 3.6 64.1 1.0
C17 A:J4D303 4.1 70.5 1.0
F22 A:J4D302 4.5 39.1 1.0
CG1 A:VAL131 4.5 16.7 1.0
CD1 A:LEU91 4.7 25.0 1.0
F19 A:J4D303 4.8 86.2 1.0
CD2 A:LEU91 4.8 29.1 1.0
N10 A:J4D303 4.9 57.0 1.0

Fluorine binding site 10 out of 15 in 6eeh

Go back to Fluorine Binding Sites List in 6eeh
Fluorine binding site 10 out of 15 in the Bioreductive 4-Hydroxy-3-Nitro-5-Ureido-Benzenesulfonamides Selectively Target the Tumor-Associated Carbonic Anhydrase Isoforms IX and XII and Show Hypoxia-Enhanced Cytotoxicity Against Human Cancer Cell Lines.


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 10 of Bioreductive 4-Hydroxy-3-Nitro-5-Ureido-Benzenesulfonamides Selectively Target the Tumor-Associated Carbonic Anhydrase Isoforms IX and XII and Show Hypoxia-Enhanced Cytotoxicity Against Human Cancer Cell Lines. within 5.0Å range:
probe atom residue distance (Å) B Occ
A:F303

b:65.6
occ:1.00
 F22 A:J4D303 0.0 65.6 1.0
C13 A:J4D303 1.4 68.0 1.0
C14 A:J4D303 2.4 71.1 1.0
C12 A:J4D303 2.4 64.1 1.0
F21 A:J4D303 2.7 69.5 1.0
N10 A:J4D303 2.8 57.0 1.0
F22 A:J4D302 2.9 39.1 1.0
F21 A:J4D302 3.1 37.0 1.0
C13 A:J4D302 3.3 36.9 1.0
C14 A:J4D302 3.4 36.1 1.0
O24 A:J4D304 3.5 50.8 1.0
CG1 A:VAL131 3.6 16.7 1.0
C15 A:J4D303 3.6 75.7 1.0
C17 A:J4D303 3.7 70.5 1.0
N23 A:J4D304 4.0 48.2 1.0
C09 A:J4D303 4.1 55.7 1.0
C16 A:J4D303 4.1 77.8 1.0
C12 A:J4D302 4.3 36.4 1.0
O25 A:J4D304 4.4 48.9 1.0
O07 A:J4D304 4.5 35.3 1.0
C15 A:J4D302 4.5 38.5 1.0
O11 A:J4D303 4.7 55.8 1.0
F20 A:J4D303 4.8 77.0 1.0
F18 A:J4D303 4.8 71.0 1.0
C02 A:J4D304 4.8 41.8 1.0
N10 A:J4D302 4.9 37.9 1.0
CB A:VAL131 5.0 13.2 1.0

Reference:

A.Nocentini, E.Trallori, S.Singh, C.L.Lomelino, G.Bartolucci, L.Di Cesare Mannelli, C.Ghelardini, R.Mckenna, P.Gratteri, C.T.Supuran. 4-Hydroxy-3-Nitro-5-Ureido-Benzenesulfonamides Selectively Target the Tumor-Associated Carbonic Anhydrase Isoforms IX and XII Showing Hypoxia-Enhanced Antiproliferative Profiles. J. Med. Chem. V. 61 10860 2018.
ISSN: ISSN 1520-4804
PubMed: 30433782
DOI: 10.1021/ACS.JMEDCHEM.8B01504
Page generated: Thu Aug 1 19:31:54 2024

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