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Fluorine in PDB 6et4: Human Dihydroorotate Dehydrogenase in Complex with Novel InhibitorEnzymatic activity of Human Dihydroorotate Dehydrogenase in Complex with Novel Inhibitor
All present enzymatic activity of Human Dihydroorotate Dehydrogenase in Complex with Novel Inhibitor:
1.3.5.2; Protein crystallography data
The structure of Human Dihydroorotate Dehydrogenase in Complex with Novel Inhibitor, PDB code: 6et4
was solved by
M.Hakansson,
B.Walse,
A.-L.Gustavsson,
S.Lain,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 6et4:
The structure of Human Dihydroorotate Dehydrogenase in Complex with Novel Inhibitor also contains other interesting chemical elements:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Human Dihydroorotate Dehydrogenase in Complex with Novel Inhibitor
(pdb code 6et4). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Human Dihydroorotate Dehydrogenase in Complex with Novel Inhibitor, PDB code: 6et4: Fluorine binding site 1 out of 1 in 6et4Go back to Fluorine Binding Sites List in 6et4
Fluorine binding site 1 out
of 1 in the Human Dihydroorotate Dehydrogenase in Complex with Novel Inhibitor
Mono view Stereo pair view
Reference:
M.J.G.W.Ladds,
I.M.M.Van Leeuwen,
C.J.Drummond,
S.Chu,
A.R.Healy,
G.Popova,
A.Pastor Fernandez,
T.Mollick,
S.Darekar,
S.K.Sedimbi,
M.Nekulova,
M.C.C.Sachweh,
J.Campbell,
M.Higgins,
C.Tuck,
M.Popa,
M.M.Safont,
P.Gelebart,
Z.Fandalyuk,
A.M.Thompson,
R.Svensson,
A.L.Gustavsson,
L.Johansson,
K.Farnegardh,
U.Yngve,
A.Saleh,
M.Haraldsson,
A.C.A.D'hollander,
M.Franco,
Y.Zhao,
M.Hakansson,
B.Walse,
K.Larsson,
E.M.Peat,
V.Pelechano,
J.Lunec,
B.Vojtesek,
M.Carmena,
W.C.Earnshaw,
A.R.Mccarthy,
N.J.Westwood,
M.Arsenian-Henriksson,
D.P.Lane,
R.Bhatia,
E.Mccormack,
S.Lain.
A Dhodh Inhibitor Increases P53 Synthesis and Enhances Tumor Cell Killing By P53 Degradation Blockage. Nat Commun V. 9 1107 2018.
Page generated: Sun Dec 13 12:49:40 2020
ISSN: ESSN 2041-1723 PubMed: 29549331 DOI: 10.1038/S41467-018-03441-3 |
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