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Fluorine in PDB 6ffn: Structure-Based Design and Synthesis of Macrocyclic Human Rhinovirus 3C Protease Inhibitors
Enzymatic activity of Structure-Based Design and Synthesis of Macrocyclic Human Rhinovirus 3C Protease Inhibitors
All present enzymatic activity of Structure-Based Design and Synthesis of Macrocyclic Human Rhinovirus 3C Protease Inhibitors:
3.4.22.28; 3.4.22.29; 3.6.1.15;
3.4.22.28; 3.4.22.29; 3.6.1.15;
Protein crystallography data
The structure of Structure-Based Design and Synthesis of Macrocyclic Human Rhinovirus 3C Protease Inhibitors, PDB code: 6ffn
was solved by
C.Wiesmann,
C.Farady,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 20.00 / 1.75 |
| Space group | P 32 2 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 77.459, 77.459, 87.863, 90.00, 90.00, 120.00 |
| R / Rfree (%) | 14.9 / 17 |
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Structure-Based Design and Synthesis of Macrocyclic Human Rhinovirus 3C Protease Inhibitors
(pdb code 6ffn). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Structure-Based Design and Synthesis of Macrocyclic Human Rhinovirus 3C Protease Inhibitors, PDB code: 6ffn:
In total only one binding site of Fluorine was determined in the Structure-Based Design and Synthesis of Macrocyclic Human Rhinovirus 3C Protease Inhibitors, PDB code: 6ffn:
Fluorine binding site 1 out of 1 in 6ffn
Go back to
Fluorine Binding Sites List in 6ffn
Fluorine binding site 1 out
of 1 in the Structure-Based Design and Synthesis of Macrocyclic Human Rhinovirus 3C Protease Inhibitors
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 1 of Structure-Based Design and Synthesis of Macrocyclic Human Rhinovirus 3C Protease Inhibitors within 5.0Å range:
|
Reference:
K.Namoto,
F.Sirockin,
H.Sellner,
C.Wiesmann,
F.Villard,
R.J.Moreau,
E.Valeur,
S.C.Paulding,
S.Schleeger,
K.Schipp,
J.Loup,
L.Andrews,
R.Swale,
M.Robinson,
C.J.Farady.
Structure-Based Design and Synthesis of Macrocyclic Human Rhinovirus 3C Protease Inhibitors. Bioorg. Med. Chem. Lett. V. 28 906 2018.
ISSN: ESSN 1464-3405
PubMed: 29433930
DOI: 10.1016/J.BMCL.2018.01.064
Page generated: Thu Aug 1 20:07:29 2024
ISSN: ESSN 1464-3405
PubMed: 29433930
DOI: 10.1016/J.BMCL.2018.01.064
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