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Atomistry » Fluorine » PDB 6g0w-6gqm » 6g0w | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Fluorine » PDB 6g0w-6gqm » 6g0w » |
Fluorine in PDB 6g0w: Human PARP14 (ARTD8), Catalytic Fragment in Complex with Inhibitor MCD72Enzymatic activity of Human PARP14 (ARTD8), Catalytic Fragment in Complex with Inhibitor MCD72
All present enzymatic activity of Human PARP14 (ARTD8), Catalytic Fragment in Complex with Inhibitor MCD72:
2.4.2.30; Protein crystallography data
The structure of Human PARP14 (ARTD8), Catalytic Fragment in Complex with Inhibitor MCD72, PDB code: 6g0w
was solved by
T.Karlberg,
A.G.Thorsell,
J.Holechek,
R.Lease,
D.Ferraris,
H.Schuler,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Human PARP14 (ARTD8), Catalytic Fragment in Complex with Inhibitor MCD72
(pdb code 6g0w). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 2 binding sites of Fluorine where determined in the Human PARP14 (ARTD8), Catalytic Fragment in Complex with Inhibitor MCD72, PDB code: 6g0w: Jump to Fluorine binding site number: 1; 2; Fluorine binding site 1 out of 2 in 6g0wGo back to![]() ![]()
Fluorine binding site 1 out
of 2 in the Human PARP14 (ARTD8), Catalytic Fragment in Complex with Inhibitor MCD72
![]() Mono view ![]() Stereo pair view
Fluorine binding site 2 out of 2 in 6g0wGo back to![]() ![]()
Fluorine binding site 2 out
of 2 in the Human PARP14 (ARTD8), Catalytic Fragment in Complex with Inhibitor MCD72
![]() Mono view ![]() Stereo pair view
Reference:
J.Holechek,
R.Lease,
A.G.Thorsell,
T.Karlberg,
C.Mccadden,
R.Grant,
A.Keen,
E.Callahan,
H.Schuler,
D.Ferraris.
Design, Synthesis and Evaluation of Potent and Selective Inhibitors of Mono-(Adp-Ribosyl)Transferases PARP10 and PARP14. Bioorg. Med. Chem. Lett. V. 28 2050 2018.
Page generated: Tue Jul 15 11:44:01 2025
ISSN: ESSN 1464-3405 PubMed: 29748053 DOI: 10.1016/J.BMCL.2018.04.056 |
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