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Fluorine in PDB 6gbx: Crystal Structure of Human Glutaminyl Cyclase Variant Y115E-Y117E in Complex with SEN177
Enzymatic activity of Crystal Structure of Human Glutaminyl Cyclase Variant Y115E-Y117E in Complex with SEN177
All present enzymatic activity of Crystal Structure of Human Glutaminyl Cyclase Variant Y115E-Y117E in Complex with SEN177:
2.3.2.5;
2.3.2.5;
Protein crystallography data
The structure of Crystal Structure of Human Glutaminyl Cyclase Variant Y115E-Y117E in Complex with SEN177, PDB code: 6gbx
was solved by
C.Pozzi,
F.Di Pisa,
M.Benvenuti,
S.Mangani,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 95.23 / 1.72 |
| Space group | C 1 2 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 86.140, 149.810, 95.980, 90.00, 97.18, 90.00 |
| R / Rfree (%) | 15.8 / 18.3 |
Other elements in 6gbx:
The structure of Crystal Structure of Human Glutaminyl Cyclase Variant Y115E-Y117E in Complex with SEN177 also contains other interesting chemical elements:
| Zinc | (Zn) | 3 atoms |
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structure of Human Glutaminyl Cyclase Variant Y115E-Y117E in Complex with SEN177
(pdb code 6gbx). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 3 binding sites of Fluorine where determined in the Crystal Structure of Human Glutaminyl Cyclase Variant Y115E-Y117E in Complex with SEN177, PDB code: 6gbx:
Jump to Fluorine binding site number: 1; 2; 3;
In total 3 binding sites of Fluorine where determined in the Crystal Structure of Human Glutaminyl Cyclase Variant Y115E-Y117E in Complex with SEN177, PDB code: 6gbx:
Jump to Fluorine binding site number: 1; 2; 3;
Fluorine binding site 1 out of 3 in 6gbx
Go back to
Fluorine Binding Sites List in 6gbx
Fluorine binding site 1 out
of 3 in the Crystal Structure of Human Glutaminyl Cyclase Variant Y115E-Y117E in Complex with SEN177
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 1 of Crystal Structure of Human Glutaminyl Cyclase Variant Y115E-Y117E in Complex with SEN177 within 5.0Å range:
|
Fluorine binding site 2 out of 3 in 6gbx
Go back to
Fluorine Binding Sites List in 6gbx
Fluorine binding site 2 out
of 3 in the Crystal Structure of Human Glutaminyl Cyclase Variant Y115E-Y117E in Complex with SEN177
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 2 of Crystal Structure of Human Glutaminyl Cyclase Variant Y115E-Y117E in Complex with SEN177 within 5.0Å range:
|
Fluorine binding site 3 out of 3 in 6gbx
Go back to
Fluorine Binding Sites List in 6gbx
Fluorine binding site 3 out
of 3 in the Crystal Structure of Human Glutaminyl Cyclase Variant Y115E-Y117E in Complex with SEN177
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 3 of Crystal Structure of Human Glutaminyl Cyclase Variant Y115E-Y117E in Complex with SEN177 within 5.0Å range:
|
Reference:
C.Pozzi,
F.Di Pisa,
M.Benvenuti,
S.Mangani.
The Structure of the Human Glutaminyl Cyclase-SEN177 Complex Indicates Routes For Developing New Potent Inhibitors As Possible Agents For the Treatment of Neurological Disorders. J. Biol. Inorg. Chem. V. 23 1219 2018.
ISSN: ESSN 1432-1327
PubMed: 30132075
DOI: 10.1007/S00775-018-1605-1
Page generated: Thu Aug 1 20:26:19 2024
ISSN: ESSN 1432-1327
PubMed: 30132075
DOI: 10.1007/S00775-018-1605-1
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