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Fluorine in PDB 6gg8: Mineralocorticoid Receptor in Complex with (S)-13Enzymatic activity of Mineralocorticoid Receptor in Complex with (S)-13
All present enzymatic activity of Mineralocorticoid Receptor in Complex with (S)-13:
2.3.1.48; Protein crystallography data
The structure of Mineralocorticoid Receptor in Complex with (S)-13, PDB code: 6gg8
was solved by
K.Edman,
A.Aagaard,
S.Tangefjord,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Mineralocorticoid Receptor in Complex with (S)-13
(pdb code 6gg8). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Mineralocorticoid Receptor in Complex with (S)-13, PDB code: 6gg8: Fluorine binding site 1 out of 1 in 6gg8Go back to Fluorine Binding Sites List in 6gg8
Fluorine binding site 1 out
of 1 in the Mineralocorticoid Receptor in Complex with (S)-13
Mono view Stereo pair view
Reference:
K.L.Granberg,
Z.Q.Yuan,
B.Lindmark,
K.Edman,
J.Kajanus,
A.Hogner,
M.Malmgren,
G.O'mahony,
A.Nordqvist,
J.Lindberg,
S.Tangefjord,
M.Kossenjans,
C.Lofberg,
J.Branalt,
D.Liu,
N.Selmi,
G.Nikitidis,
P.Nordberg,
A.Hayen,
A.Aagaard,
E.Hansson,
M.Hermansson,
I.Ivarsson,
R.Jansson-Lofmark,
U.Karlsson,
U.Johansson,
L.William-Olsson,
J.Hartleib-Geschwindner,
K.Bamberg.
Identification of Mineralocorticoid Receptor Modulators with Low Impact on Electrolyte Homeostasis But Maintained Organ Protection. J.Med.Chem. V. 62 1385 2019.
Page generated: Sun Dec 13 12:51:24 2020
ISSN: ISSN 0022-2623 PubMed: 30596500 DOI: 10.1021/ACS.JMEDCHEM.8B01523 |
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