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Fluorine in PDB 6gou: Development of Alkyl Glycerone Phosphate Synthase Inhibitors: Complex with Inhibitor 2I
Enzymatic activity of Development of Alkyl Glycerone Phosphate Synthase Inhibitors: Complex with Inhibitor 2I
All present enzymatic activity of Development of Alkyl Glycerone Phosphate Synthase Inhibitors: Complex with Inhibitor 2I:
2.5.1.26;
2.5.1.26;
Protein crystallography data
The structure of Development of Alkyl Glycerone Phosphate Synthase Inhibitors: Complex with Inhibitor 2I, PDB code: 6gou
was solved by
A.Mattevi,
V.Piano,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 48.00 / 2.90 |
| Space group | I 1 2 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 147.958, 120.644, 148.160, 90.00, 95.27, 90.00 |
| R / Rfree (%) | 21.9 / 25.8 |
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Development of Alkyl Glycerone Phosphate Synthase Inhibitors: Complex with Inhibitor 2I
(pdb code 6gou). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 6 binding sites of Fluorine where determined in the Development of Alkyl Glycerone Phosphate Synthase Inhibitors: Complex with Inhibitor 2I, PDB code: 6gou:
Jump to Fluorine binding site number: 1; 2; 3; 4; 5; 6;
In total 6 binding sites of Fluorine where determined in the Development of Alkyl Glycerone Phosphate Synthase Inhibitors: Complex with Inhibitor 2I, PDB code: 6gou:
Jump to Fluorine binding site number: 1; 2; 3; 4; 5; 6;
Fluorine binding site 1 out of 6 in 6gou
Go back to
Fluorine Binding Sites List in 6gou
Fluorine binding site 1 out
of 6 in the Development of Alkyl Glycerone Phosphate Synthase Inhibitors: Complex with Inhibitor 2I
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 1 of Development of Alkyl Glycerone Phosphate Synthase Inhibitors: Complex with Inhibitor 2I within 5.0Å range:
|
Fluorine binding site 2 out of 6 in 6gou
Go back to
Fluorine Binding Sites List in 6gou
Fluorine binding site 2 out
of 6 in the Development of Alkyl Glycerone Phosphate Synthase Inhibitors: Complex with Inhibitor 2I
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 2 of Development of Alkyl Glycerone Phosphate Synthase Inhibitors: Complex with Inhibitor 2I within 5.0Å range:
|
Fluorine binding site 3 out of 6 in 6gou
Go back to
Fluorine Binding Sites List in 6gou
Fluorine binding site 3 out
of 6 in the Development of Alkyl Glycerone Phosphate Synthase Inhibitors: Complex with Inhibitor 2I
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 3 of Development of Alkyl Glycerone Phosphate Synthase Inhibitors: Complex with Inhibitor 2I within 5.0Å range:
|
Fluorine binding site 4 out of 6 in 6gou
Go back to
Fluorine Binding Sites List in 6gou
Fluorine binding site 4 out
of 6 in the Development of Alkyl Glycerone Phosphate Synthase Inhibitors: Complex with Inhibitor 2I
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 4 of Development of Alkyl Glycerone Phosphate Synthase Inhibitors: Complex with Inhibitor 2I within 5.0Å range:
|
Fluorine binding site 5 out of 6 in 6gou
Go back to
Fluorine Binding Sites List in 6gou
Fluorine binding site 5 out
of 6 in the Development of Alkyl Glycerone Phosphate Synthase Inhibitors: Complex with Inhibitor 2I
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 5 of Development of Alkyl Glycerone Phosphate Synthase Inhibitors: Complex with Inhibitor 2I within 5.0Å range:
|
Fluorine binding site 6 out of 6 in 6gou
Go back to
Fluorine Binding Sites List in 6gou
Fluorine binding site 6 out
of 6 in the Development of Alkyl Glycerone Phosphate Synthase Inhibitors: Complex with Inhibitor 2I
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 6 of Development of Alkyl Glycerone Phosphate Synthase Inhibitors: Complex with Inhibitor 2I within 5.0Å range:
|
Reference:
G.Stazi,
C.Battistelli,
V.Piano,
R.Mazzone,
B.Marrocco,
S.Marchese,
S.M.Louie,
C.Zwergel,
L.Antonini,
A.Patsilinakos,
R.Ragno,
M.Viviano,
G.Sbardella,
A.Ciogli,
G.Fabrizi,
R.Cirilli,
R.Strippoli,
A.Marchetti,
M.Tripodi,
D.K.Nomura,
A.Mattevi,
A.Mai,
S.Valente.
Development of Alkyl Glycerone Phosphate Synthase Inhibitors: Structure-Activity Relationship and Effects on Ether Lipids and Epithelial-Mesenchymal Transition in Cancer Cells. Eur J Med Chem V. 163 722 2018.
ISSN: ISSN 1768-3254
PubMed: 30576903
DOI: 10.1016/J.EJMECH.2018.11.050
Page generated: Thu Aug 1 20:34:18 2024
ISSN: ISSN 1768-3254
PubMed: 30576903
DOI: 10.1016/J.EJMECH.2018.11.050
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