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Fluorine in PDB 6gpj: Crystal Structure of Human Gdp-D-Mannose 4,6-Dehydratase in Complex with Gdp-4F-Man
Enzymatic activity of Crystal Structure of Human Gdp-D-Mannose 4,6-Dehydratase in Complex with Gdp-4F-Man
All present enzymatic activity of Crystal Structure of Human Gdp-D-Mannose 4,6-Dehydratase in Complex with Gdp-4F-Man:
4.2.1.47;
4.2.1.47;
Protein crystallography data
The structure of Crystal Structure of Human Gdp-D-Mannose 4,6-Dehydratase in Complex with Gdp-4F-Man, PDB code: 6gpj
was solved by
M.Pfeiffer,
T.Krojer,
C.Johansson,
F.Von Delft,
C.Bountra,
C.H.Arrowsmith,
A.Edwards,
B.Nidetzky,
U.Oppermann,
Structural Genomics Consortium(Sgc),
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 63.90 / 1.94 |
| Space group | P 21 21 21 |
| Cell size a, b, c (Å), α, β, γ (°) | 92.080, 114.438, 140.536, 90.00, 90.00, 90.00 |
| R / Rfree (%) | 21 / 23.8 |
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structure of Human Gdp-D-Mannose 4,6-Dehydratase in Complex with Gdp-4F-Man
(pdb code 6gpj). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 4 binding sites of Fluorine where determined in the Crystal Structure of Human Gdp-D-Mannose 4,6-Dehydratase in Complex with Gdp-4F-Man, PDB code: 6gpj:
Jump to Fluorine binding site number: 1; 2; 3; 4;
In total 4 binding sites of Fluorine where determined in the Crystal Structure of Human Gdp-D-Mannose 4,6-Dehydratase in Complex with Gdp-4F-Man, PDB code: 6gpj:
Jump to Fluorine binding site number: 1; 2; 3; 4;
Fluorine binding site 1 out of 4 in 6gpj
Go back to
Fluorine Binding Sites List in 6gpj
Fluorine binding site 1 out
of 4 in the Crystal Structure of Human Gdp-D-Mannose 4,6-Dehydratase in Complex with Gdp-4F-Man
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 1 of Crystal Structure of Human Gdp-D-Mannose 4,6-Dehydratase in Complex with Gdp-4F-Man within 5.0Å range:
|
Fluorine binding site 2 out of 4 in 6gpj
Go back to
Fluorine Binding Sites List in 6gpj
Fluorine binding site 2 out
of 4 in the Crystal Structure of Human Gdp-D-Mannose 4,6-Dehydratase in Complex with Gdp-4F-Man
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 2 of Crystal Structure of Human Gdp-D-Mannose 4,6-Dehydratase in Complex with Gdp-4F-Man within 5.0Å range:
|
Fluorine binding site 3 out of 4 in 6gpj
Go back to
Fluorine Binding Sites List in 6gpj
Fluorine binding site 3 out
of 4 in the Crystal Structure of Human Gdp-D-Mannose 4,6-Dehydratase in Complex with Gdp-4F-Man
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 3 of Crystal Structure of Human Gdp-D-Mannose 4,6-Dehydratase in Complex with Gdp-4F-Man within 5.0Å range:
|
Fluorine binding site 4 out of 4 in 6gpj
Go back to
Fluorine Binding Sites List in 6gpj
Fluorine binding site 4 out
of 4 in the Crystal Structure of Human Gdp-D-Mannose 4,6-Dehydratase in Complex with Gdp-4F-Man
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 4 of Crystal Structure of Human Gdp-D-Mannose 4,6-Dehydratase in Complex with Gdp-4F-Man within 5.0Å range:
|
Reference:
M.Pfeiffer,
C.Johansson,
T.Krojer,
K.L.Kavanagh,
U.Oppermann,
B.Nidetzky.
A Parsimonious Mechanism of Sugar Dehydration By Human Gdp-Mannose-4,6-Dehydratase. Acs Catalysis V. 9 2962 2019.
ISSN: ESSN 2155-5435
PubMed: 30984471
DOI: 10.1021/ACSCATAL.9B00064
Page generated: Thu Aug 1 20:34:41 2024
ISSN: ESSN 2155-5435
PubMed: 30984471
DOI: 10.1021/ACSCATAL.9B00064
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