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Fluorine in PDB 6h8r: Crystal Structure of the Human Protein Tyrosine Phosphatase PTPN5 (Step) in Complex with Compound 2Enzymatic activity of Crystal Structure of the Human Protein Tyrosine Phosphatase PTPN5 (Step) in Complex with Compound 2
All present enzymatic activity of Crystal Structure of the Human Protein Tyrosine Phosphatase PTPN5 (Step) in Complex with Compound 2:
3.1.3.48; Protein crystallography data
The structure of Crystal Structure of the Human Protein Tyrosine Phosphatase PTPN5 (Step) in Complex with Compound 2, PDB code: 6h8r
was solved by
S.Hoerer,
D.Fiegen,
G.Schnapp,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structure of the Human Protein Tyrosine Phosphatase PTPN5 (Step) in Complex with Compound 2
(pdb code 6h8r). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 3 binding sites of Fluorine where determined in the Crystal Structure of the Human Protein Tyrosine Phosphatase PTPN5 (Step) in Complex with Compound 2, PDB code: 6h8r: Jump to Fluorine binding site number: 1; 2; 3; Fluorine binding site 1 out of 3 in 6h8rGo back to Fluorine Binding Sites List in 6h8r
Fluorine binding site 1 out
of 3 in the Crystal Structure of the Human Protein Tyrosine Phosphatase PTPN5 (Step) in Complex with Compound 2
Mono view Stereo pair view
Fluorine binding site 2 out of 3 in 6h8rGo back to Fluorine Binding Sites List in 6h8r
Fluorine binding site 2 out
of 3 in the Crystal Structure of the Human Protein Tyrosine Phosphatase PTPN5 (Step) in Complex with Compound 2
Mono view Stereo pair view
Fluorine binding site 3 out of 3 in 6h8rGo back to Fluorine Binding Sites List in 6h8r
Fluorine binding site 3 out
of 3 in the Crystal Structure of the Human Protein Tyrosine Phosphatase PTPN5 (Step) in Complex with Compound 2
Mono view Stereo pair view
Reference:
C.S.Tautermann,
F.Binder,
F.H.Buttner,
C.Eickmeier,
D.Fiegen,
U.Gross,
M.A.Grundl,
R.Heilker,
S.Hobson,
S.Hoerer,
A.Luippold,
V.Mack,
F.Montel,
S.Peters,
S.Bhattacharya,
N.Vaidehi,
G.Schnapp,
S.Thamm,
M.Zeeb.
Allosteric Activation of Striatal-Enriched Protein Tyrosine Phosphatase (Step, PTPN5) By A Fragment-Like Molecule. J. Med. Chem. V. 62 306 2019.
Page generated: Sun Dec 13 12:52:01 2020
ISSN: ISSN 1520-4804 PubMed: 30207464 DOI: 10.1021/ACS.JMEDCHEM.8B00857 |
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