Fluorine in PDB 6jtg: Structural Insights Into G Domain Dimerization and Pathogenic Mutations of OPA1

All present enzymatic activity of Structural Insights Into G Domain Dimerization and Pathogenic Mutations of OPA1:
3.6.5.5;

The structure of Structural Insights Into G Domain Dimerization and Pathogenic Mutations of OPA1, PDB code: 6jtg was solved by L.Yan, J.Hu, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	46.35 / 2.40
Space group	P 43 21 2
Cell size a, b, c (Å), α, β, γ (°)	77.890, 77.890, 171.547, 90.00, 90.00, 90.00
R / Rfree (%)	19.9 / 24.4

The structure of Structural Insights Into G Domain Dimerization and Pathogenic Mutations of OPA1 also contains other interesting chemical elements:

Magnesium	(Mg)	1 atom
Potassium	(K)	1 atom

The binding sites of Fluorine atom in the Structural Insights Into G Domain Dimerization and Pathogenic Mutations of OPA1 (pdb code 6jtg). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total 3 binding sites of Fluorine where determined in the Structural Insights Into G Domain Dimerization and Pathogenic Mutations of OPA1, PDB code: 6jtg:
Jump to Fluorine binding site number: 1; 2; 3;

Fluorine binding site 1 out of 3 in the Structural Insights Into G Domain Dimerization and Pathogenic Mutations of OPA1


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Structural Insights Into G Domain Dimerization and Pathogenic Mutations of OPA1 within 5.0Å range: probe atom residue distance (Å) B Occ A:F403 b:7.1 occ:1.00 F1 A:BEF403 0.0 7.1 1.0 BE A:BEF403 1.5 6.9 1.0 F3 A:BEF403 2.5 7.0 1.0 F2 A:BEF403 2.5 6.9 1.0 O1B A:GDP401 2.5 18.6 1.0 K A:K404 2.8 30.0 1.0 N A:MET60 2.9 24.4 1.0 O A:HOH517 3.2 21.0 1.0 N A:THR61 3.6 25.9 1.0 CB A:MET60 3.6 21.0 1.0 CA A:MET60 3.7 22.5 1.0 O A:GLU58 3.8 30.1 1.0 PB A:GDP401 3.9 21.3 1.0 C A:MET59 3.9 29.2 1.0 CA A:MET59 4.0 26.7 1.0 CG A:GLN35 4.1 19.2 1.0 C A:MET60 4.1 27.9 1.0 MG A:MG402 4.2 31.9 1.0 N A:SER36 4.3 17.9 1.0 O3B A:GDP401 4.3 18.4 1.0 O A:HOH516 4.5 22.8 1.0 CG A:MET60 4.5 28.6 1.0 OG1 A:THR61 4.5 21.3 1.0 CB A:THR61 4.6 21.7 1.0 O1A A:GDP401 4.7 23.4 1.0 CA A:THR61 4.7 22.2 1.0 N A:GLY139 4.7 21.7 1.0 C A:GLU58 4.7 27.1 1.0 O3A A:GDP401 4.8 24.6 1.0 O2B A:GDP401 4.8 22.8 1.0 CA A:GLN35 4.8 21.1 1.0 NZ A:LYS39 4.8 16.8 1.0 N A:MET59 4.8 23.7 1.0 CB A:GLN35 5.0 18.9 1.0 CA A:SER36 5.0 20.4 1.0 CD A:GLN35 5.0 26.7 1.0 OG A:SER36 5.0 21.2 1.0

Fluorine binding site 2 out of 3 in the Structural Insights Into G Domain Dimerization and Pathogenic Mutations of OPA1


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 2 of Structural Insights Into G Domain Dimerization and Pathogenic Mutations of OPA1 within 5.0Å range: probe atom residue distance (Å) B Occ A:F403 b:6.9 occ:1.00 F2 A:BEF403 0.0 6.9 1.0 BE A:BEF403 1.5 6.9 1.0 F3 A:BEF403 2.5 7.0 1.0 F1 A:BEF403 2.5 7.1 1.0 O1B A:GDP401 2.5 18.6 1.0 NZ A:LYS39 2.6 16.8 1.0 CA A:GLY139 2.9 22.3 1.0 N A:GLY139 3.0 21.7 1.0 O A:HOH517 3.1 21.0 1.0 CA A:GLN35 3.3 21.1 1.0 CE A:LYS39 3.3 19.2 1.0 N A:SER36 3.4 17.9 1.0 PB A:GDP401 3.6 21.3 1.0 O2B A:GDP401 3.7 22.8 1.0 C A:GLN35 3.9 21.6 1.0 O A:HOH516 3.9 22.8 1.0 CG A:GLN35 3.9 19.2 1.0 CB A:GLN35 4.0 18.9 1.0 N A:GLN35 4.1 18.7 1.0 O3B A:GDP401 4.2 18.4 1.0 O A:ASP34 4.2 16.6 1.0 C A:PRO138 4.2 23.0 1.0 C A:GLY139 4.2 20.7 1.0 K A:K404 4.3 30.0 1.0 MG A:MG402 4.4 31.9 1.0 C A:ASP34 4.5 18.8 1.0 CA A:SER36 4.6 20.4 1.0 O A:GLY139 4.7 18.4 1.0 O A:LEU137 4.8 24.5 1.0 CD A:LYS39 4.8 19.7 1.0 CA A:PRO138 4.9 23.5 1.0 O3A A:GDP401 4.9 24.6 1.0 O A:GLY33 4.9 22.1 1.0

Fluorine binding site 3 out of 3 in the Structural Insights Into G Domain Dimerization and Pathogenic Mutations of OPA1


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 3 of Structural Insights Into G Domain Dimerization and Pathogenic Mutations of OPA1 within 5.0Å range: probe atom residue distance (Å) B Occ A:F403 b:7.0 occ:1.00 F3 A:BEF403 0.0 7.0 1.0 BE A:BEF403 1.5 6.9 1.0 MG A:MG402 2.0 31.9 1.0 O1B A:GDP401 2.4 18.6 1.0 F2 A:BEF403 2.5 6.9 1.0 F1 A:BEF403 2.5 7.1 1.0 O3B A:GDP401 2.6 18.4 1.0 PB A:GDP401 2.9 21.3 1.0 OG1 A:THR61 3.1 21.3 1.0 CB A:THR61 3.4 21.7 1.0 NZ A:LYS39 3.6 16.8 1.0 O A:HOH517 3.6 21.0 1.0 CE A:LYS39 3.6 19.2 1.0 O2B A:GDP401 3.7 22.8 1.0 OG1 A:THR40 3.8 21.6 1.0 N A:THR61 3.9 25.9 1.0 O A:LEU137 4.2 24.5 1.0 N A:GLY139 4.3 21.7 1.0 O3A A:GDP401 4.3 24.6 1.0 CA A:THR61 4.3 22.2 1.0 K A:K404 4.4 30.0 1.0 CG2 A:THR61 4.6 20.9 1.0 O1A A:GDP401 4.6 23.4 1.0 CA A:GLY139 4.8 22.3 1.0 C A:MET60 4.9 27.9 1.0 CB A:MET60 4.9 21.0 1.0 N A:MET60 4.9 24.4 1.0 CB A:LYS39 4.9 18.1 1.0 CB A:THR40 4.9 22.5 1.0 N A:THR40 4.9 20.8 1.0 C A:PRO138 5.0 23.0 1.0

L.Yan, J.Hu. Structural Insights Into G Domain Dimerization and Pathogenic Mutations of OPA1 To Be Published.