Fluorine in PDB 6kk7: Structure of Thermal-Stabilised(M6) Human Glp-1 Receptor Transmembrane Domain

The structure of Structure of Thermal-Stabilised(M6) Human Glp-1 Receptor Transmembrane Domain, PDB code: 6kk7 was solved by G.J.Song, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	40.39 / 3.10
Space group	P 1
Cell size a, b, c (Å), α, β, γ (°)	65.230, 71.060, 81.000, 92.48, 92.61, 105.10
R / Rfree (%)	25.7 / 30.3

The binding sites of Fluorine atom in the Structure of Thermal-Stabilised(M6) Human Glp-1 Receptor Transmembrane Domain (pdb code 6kk7). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total 6 binding sites of Fluorine where determined in the Structure of Thermal-Stabilised(M6) Human Glp-1 Receptor Transmembrane Domain, PDB code: 6kk7:
Jump to Fluorine binding site number: 1; 2; 3; 4; 5; 6;

Fluorine binding site 1 out of 6 in the Structure of Thermal-Stabilised(M6) Human Glp-1 Receptor Transmembrane Domain


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Structure of Thermal-Stabilised(M6) Human Glp-1 Receptor Transmembrane Domain within 5.0Å range: probe atom residue distance (Å) B Occ A:F2001 b:92.0 occ:1.00 F01 A:97Y2001 0.0 92.0 1.0 C21 A:97Y2001 1.4 73.4 1.0 F02 A:97Y2001 2.2 79.9 1.0 F03 A:97Y2001 2.2 66.3 1.0 C18 A:97Y2001 2.4 62.2 1.0 N09 A:97Y2001 2.8 61.4 1.0 C22 A:97Y2001 3.7 54.5 1.0 CD1 A:LEU335 4.0 78.8 1.0 C23 A:97Y2001 4.1 57.5 1.0 CG1 A:VAL331 4.3 85.2 1.0 CE1 A:PHE347 4.4 0.9 1.0 CB A:VAL331 4.5 76.1 1.0 N07 A:97Y2001 4.5 57.2 1.0 CD1 B:LEU290 4.7 0.1 1.0 CG1 A:VAL332 4.8 75.0 1.0 CG2 A:ILE328 4.9 0.1 1.0 CG2 B:ILE286 5.0 0.4 1.0

Fluorine binding site 2 out of 6 in the Structure of Thermal-Stabilised(M6) Human Glp-1 Receptor Transmembrane Domain


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 2 of Structure of Thermal-Stabilised(M6) Human Glp-1 Receptor Transmembrane Domain within 5.0Å range: probe atom residue distance (Å) B Occ A:F2001 b:79.9 occ:1.00 F02 A:97Y2001 0.0 79.9 1.0 C21 A:97Y2001 1.4 73.4 1.0 F01 A:97Y2001 2.2 92.0 1.0 F03 A:97Y2001 2.2 66.3 1.0 C18 A:97Y2001 2.4 62.2 1.0 C22 A:97Y2001 3.2 54.5 1.0 N09 A:97Y2001 3.3 61.4 1.0 CG2 A:ILE328 3.5 0.1 1.0 CG2 B:ILE286 4.0 0.4 1.0 CD1 B:ILE286 4.0 95.0 1.0 N07 A:97Y2001 4.3 57.2 1.0 C23 A:97Y2001 4.3 57.5 1.0 CG1 A:VAL332 4.7 75.0 1.0 CB A:ILE328 4.8 95.0 1.0 CG1 B:ILE286 4.9 0.4 1.0

Fluorine binding site 3 out of 6 in the Structure of Thermal-Stabilised(M6) Human Glp-1 Receptor Transmembrane Domain


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 3 of Structure of Thermal-Stabilised(M6) Human Glp-1 Receptor Transmembrane Domain within 5.0Å range: probe atom residue distance (Å) B Occ A:F2001 b:66.3 occ:1.00 F03 A:97Y2001 0.0 66.3 1.0 C21 A:97Y2001 1.4 73.4 1.0 F02 A:97Y2001 2.2 79.9 1.0 F01 A:97Y2001 2.2 92.0 1.0 C18 A:97Y2001 2.4 62.2 1.0 C22 A:97Y2001 2.9 54.5 1.0 N09 A:97Y2001 3.6 61.4 1.0 CG2 A:ILE328 3.8 0.1 1.0 CB A:VAL331 4.0 76.1 1.0 N07 A:97Y2001 4.1 57.2 1.0 CG1 A:VAL331 4.4 85.2 1.0 CG2 A:VAL331 4.4 74.4 1.0 C23 A:97Y2001 4.4 57.5 1.0 CD1 A:LEU354 4.5 89.3 1.0 CB A:ILE328 4.5 95.0 1.0 CA A:ILE328 4.6 80.3 1.0 CG1 A:ILE328 4.6 97.6 1.0 O A:ILE328 4.9 0.1 1.0 CE1 A:PHE347 5.0 0.9 1.0

Fluorine binding site 4 out of 6 in the Structure of Thermal-Stabilised(M6) Human Glp-1 Receptor Transmembrane Domain


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 4 of Structure of Thermal-Stabilised(M6) Human Glp-1 Receptor Transmembrane Domain within 5.0Å range: probe atom residue distance (Å) B Occ B:F2001 b:1.0 occ:1.00 F01 B:97Y2001 0.0 1.0 1.0 C21 B:97Y2001 1.3 89.7 1.0 F02 B:97Y2001 2.1 0.6 1.0 F03 B:97Y2001 2.2 86.1 1.0 C18 B:97Y2001 2.3 80.6 1.0 N09 B:97Y2001 2.9 78.0 1.0 CE1 B:PHE347 3.5 64.8 1.0 C22 B:97Y2001 3.5 61.5 1.0 CD1 B:LEU335 3.5 72.4 1.0 CG1 B:VAL331 3.8 76.3 1.0 C23 B:97Y2001 4.1 70.5 1.0 CB B:VAL331 4.1 69.4 1.0 CD1 B:PHE347 4.3 71.2 1.0 N07 B:97Y2001 4.4 61.2 1.0 CZ B:PHE347 4.4 68.3 1.0 N B:VAL332 4.8 97.6 1.0 CG1 B:VAL332 4.8 69.3 1.0 C B:VAL331 4.8 93.6 1.0 CG B:LEU335 5.0 66.1 1.0

Fluorine binding site 5 out of 6 in the Structure of Thermal-Stabilised(M6) Human Glp-1 Receptor Transmembrane Domain


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 5 of Structure of Thermal-Stabilised(M6) Human Glp-1 Receptor Transmembrane Domain within 5.0Å range: probe atom residue distance (Å) B Occ B:F2001 b:0.6 occ:1.00 F02 B:97Y2001 0.0 0.6 1.0 C21 B:97Y2001 1.3 89.7 1.0 F01 B:97Y2001 2.1 1.0 1.0 F03 B:97Y2001 2.2 86.1 1.0 C18 B:97Y2001 2.3 80.6 1.0 N09 B:97Y2001 2.9 78.0 1.0 C22 B:97Y2001 3.6 61.5 1.0 C23 B:97Y2001 4.0 70.5 1.0 N07 B:97Y2001 4.4 61.2 1.0 CG1 B:VAL332 4.5 69.3 1.0 CD1 B:LEU335 5.0 72.4 1.0

Fluorine binding site 6 out of 6 in the Structure of Thermal-Stabilised(M6) Human Glp-1 Receptor Transmembrane Domain


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 6 of Structure of Thermal-Stabilised(M6) Human Glp-1 Receptor Transmembrane Domain within 5.0Å range: probe atom residue distance (Å) B Occ B:F2001 b:86.1 occ:1.00 F03 B:97Y2001 0.0 86.1 1.0 C21 B:97Y2001 1.3 89.7 1.0 F02 B:97Y2001 2.2 0.6 1.0 F01 B:97Y2001 2.2 1.0 1.0 C18 B:97Y2001 2.3 80.6 1.0 C22 B:97Y2001 2.9 61.5 1.0 N09 B:97Y2001 3.5 78.0 1.0 N07 B:97Y2001 4.1 61.2 1.0 C23 B:97Y2001 4.4 70.5 1.0 CG2 B:ILE328 4.8 83.0 1.0 CB B:VAL331 4.9 69.4 1.0 CG1 B:ILE328 4.9 95.3 1.0 CG1 B:VAL332 5.0 69.3 1.0

Y.M.Xu, Y.X.Wang, Y.Wang, K.W.Liu, Y.Peng, D.Q.Yao, H.Tao, H.G.Liu, G.J.Song. Mutagenesis Facilitated Crystallization of Glp-1R Iucrj V. 6 996 2019.
ISSN: ESSN 2052-2525
DOI: 10.1107/S2052252519013496