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Atomistry » Fluorine » PDB 6kk1-6lqg » 6kzc | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Fluorine » PDB 6kk1-6lqg » 6kzc » |
Fluorine in PDB 6kzc: Crystal Structure of Trkc in Complex with 3-(Imidazo[1,2-A]Pyrazin-3- Ylethynyl)-2-Methyl-N-(3-((4- Methylpiperazin-1-Yl)Methyl)-5- (Trifluoromethyl)Phenyl)BenzamideEnzymatic activity of Crystal Structure of Trkc in Complex with 3-(Imidazo[1,2-A]Pyrazin-3- Ylethynyl)-2-Methyl-N-(3-((4- Methylpiperazin-1-Yl)Methyl)-5- (Trifluoromethyl)Phenyl)Benzamide
All present enzymatic activity of Crystal Structure of Trkc in Complex with 3-(Imidazo[1,2-A]Pyrazin-3- Ylethynyl)-2-Methyl-N-(3-((4- Methylpiperazin-1-Yl)Methyl)-5- (Trifluoromethyl)Phenyl)Benzamide:
2.7.10.1; Protein crystallography data
The structure of Crystal Structure of Trkc in Complex with 3-(Imidazo[1,2-A]Pyrazin-3- Ylethynyl)-2-Methyl-N-(3-((4- Methylpiperazin-1-Yl)Methyl)-5- (Trifluoromethyl)Phenyl)Benzamide, PDB code: 6kzc
was solved by
Z.M.Zhang,
Y.Wang,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structure of Trkc in Complex with 3-(Imidazo[1,2-A]Pyrazin-3- Ylethynyl)-2-Methyl-N-(3-((4- Methylpiperazin-1-Yl)Methyl)-5- (Trifluoromethyl)Phenyl)Benzamide
(pdb code 6kzc). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 3 binding sites of Fluorine where determined in the Crystal Structure of Trkc in Complex with 3-(Imidazo[1,2-A]Pyrazin-3- Ylethynyl)-2-Methyl-N-(3-((4- Methylpiperazin-1-Yl)Methyl)-5- (Trifluoromethyl)Phenyl)Benzamide, PDB code: 6kzc: Jump to Fluorine binding site number: 1; 2; 3; Fluorine binding site 1 out of 3 in 6kzcGo back to Fluorine Binding Sites List in 6kzc
Fluorine binding site 1 out
of 3 in the Crystal Structure of Trkc in Complex with 3-(Imidazo[1,2-A]Pyrazin-3- Ylethynyl)-2-Methyl-N-(3-((4- Methylpiperazin-1-Yl)Methyl)-5- (Trifluoromethyl)Phenyl)Benzamide
Mono view Stereo pair view
Fluorine binding site 2 out of 3 in 6kzcGo back to Fluorine Binding Sites List in 6kzc
Fluorine binding site 2 out
of 3 in the Crystal Structure of Trkc in Complex with 3-(Imidazo[1,2-A]Pyrazin-3- Ylethynyl)-2-Methyl-N-(3-((4- Methylpiperazin-1-Yl)Methyl)-5- (Trifluoromethyl)Phenyl)Benzamide
Mono view Stereo pair view
Fluorine binding site 3 out of 3 in 6kzcGo back to Fluorine Binding Sites List in 6kzc
Fluorine binding site 3 out
of 3 in the Crystal Structure of Trkc in Complex with 3-(Imidazo[1,2-A]Pyrazin-3- Ylethynyl)-2-Methyl-N-(3-((4- Methylpiperazin-1-Yl)Methyl)-5- (Trifluoromethyl)Phenyl)Benzamide
Mono view Stereo pair view
Reference:
S.Cui,
Y.Wang,
Y.Wang,
X.Tang,
X.Ren,
L.Zhang,
Y.Xu,
Z.Zhang,
Z.M.Zhang,
X.Lu,
K.Ding.
Design, Synthesis and Biological Evaluation of 3-(Imidazo[1,2-A]Pyrazin-3-Ylethynyl)-2-Methylbenzamides As Potent and Selective Pan-Tropomyosin Receptor Kinase (Trk) Inhibitors. Eur.J.Med.Chem. V. 179 470 2019.
Page generated: Thu Aug 1 21:54:25 2024
ISSN: ISSN 0223-5234 PubMed: 31271959 DOI: 10.1016/J.EJMECH.2019.06.064 |
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