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Fluorine in PDB 6kzu: Macrocyclization of An All-D Linear Peptide Improves Target Affinity and Imparts Cellular Activity: A Novel Stapled Alpha-Helical Peptide Modality
Enzymatic activity of Macrocyclization of An All-D Linear Peptide Improves Target Affinity and Imparts Cellular Activity: A Novel Stapled Alpha-Helical Peptide Modality
All present enzymatic activity of Macrocyclization of An All-D Linear Peptide Improves Target Affinity and Imparts Cellular Activity: A Novel Stapled Alpha-Helical Peptide Modality:
2.3.2.27;
2.3.2.27;
Protein crystallography data
The structure of Macrocyclization of An All-D Linear Peptide Improves Target Affinity and Imparts Cellular Activity: A Novel Stapled Alpha-Helical Peptide Modality, PDB code: 6kzu
was solved by
S.Jiang,
C.J.Brown,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 43.49 / 1.79 |
| Space group | P 61 2 2 |
| Cell size a, b, c (Å), α, β, γ (°) | 82.567, 82.567, 54.783, 90.00, 90.00, 120.00 |
| R / Rfree (%) | 19.9 / 23.6 |
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Macrocyclization of An All-D Linear Peptide Improves Target Affinity and Imparts Cellular Activity: A Novel Stapled Alpha-Helical Peptide Modality
(pdb code 6kzu). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 4 binding sites of Fluorine where determined in the Macrocyclization of An All-D Linear Peptide Improves Target Affinity and Imparts Cellular Activity: A Novel Stapled Alpha-Helical Peptide Modality, PDB code: 6kzu:
Jump to Fluorine binding site number: 1; 2; 3; 4;
In total 4 binding sites of Fluorine where determined in the Macrocyclization of An All-D Linear Peptide Improves Target Affinity and Imparts Cellular Activity: A Novel Stapled Alpha-Helical Peptide Modality, PDB code: 6kzu:
Jump to Fluorine binding site number: 1; 2; 3; 4;
Fluorine binding site 1 out of 4 in 6kzu
Go back to
Fluorine Binding Sites List in 6kzu
Fluorine binding site 1 out
of 4 in the Macrocyclization of An All-D Linear Peptide Improves Target Affinity and Imparts Cellular Activity: A Novel Stapled Alpha-Helical Peptide Modality
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 1 of Macrocyclization of An All-D Linear Peptide Improves Target Affinity and Imparts Cellular Activity: A Novel Stapled Alpha-Helical Peptide Modality within 5.0Å range:
|
Fluorine binding site 2 out of 4 in 6kzu
Go back to
Fluorine Binding Sites List in 6kzu
Fluorine binding site 2 out
of 4 in the Macrocyclization of An All-D Linear Peptide Improves Target Affinity and Imparts Cellular Activity: A Novel Stapled Alpha-Helical Peptide Modality
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 2 of Macrocyclization of An All-D Linear Peptide Improves Target Affinity and Imparts Cellular Activity: A Novel Stapled Alpha-Helical Peptide Modality within 5.0Å range:
|
Fluorine binding site 3 out of 4 in 6kzu
Go back to
Fluorine Binding Sites List in 6kzu
Fluorine binding site 3 out
of 4 in the Macrocyclization of An All-D Linear Peptide Improves Target Affinity and Imparts Cellular Activity: A Novel Stapled Alpha-Helical Peptide Modality
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 3 of Macrocyclization of An All-D Linear Peptide Improves Target Affinity and Imparts Cellular Activity: A Novel Stapled Alpha-Helical Peptide Modality within 5.0Å range:
|
Fluorine binding site 4 out of 4 in 6kzu
Go back to
Fluorine Binding Sites List in 6kzu
Fluorine binding site 4 out
of 4 in the Macrocyclization of An All-D Linear Peptide Improves Target Affinity and Imparts Cellular Activity: A Novel Stapled Alpha-Helical Peptide Modality
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 4 of Macrocyclization of An All-D Linear Peptide Improves Target Affinity and Imparts Cellular Activity: A Novel Stapled Alpha-Helical Peptide Modality within 5.0Å range:
|
Reference:
K.Srinivasaraghavan,
G.A.Pietro,
S.Ng,
D.Thean,
Y.Frosi,
S.Chee,
S.Jiang,
T.Z.Yuen,
A.Sadruddin,
Y.K.Hung,
A.Chandramohan,
J.H.Wong,
Y.S.Tan,
F.J.Ferrer,
P.Arumugam,
Y.Han,
S.Chen,
C.J.Brown,
C.W.Johannes,
B.Henry,
D.P.Lane,
T.K.Sawyer,
C.S.Verma,
P.W.Partridge.
Macrocyclization of An All-D Linear Peptide Improves Target Affinity and Imparts Cellular Activity: A Novel Stapled Alpha-Helical Peptide Modality To Be Published.
Page generated: Thu Aug 1 21:54:30 2024
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